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CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer.

Ma T, Wu J, Li S, Chen J
Cancer Res. 2026 Jul 22. doi: 10.1158/0008-5472.CAN-26-1023. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
259552pLentiV2_sgRNA_SMARCAL1knock out SMARCAL1 in human cells
259553PX330_sgRNA_rad50knock out RAD50 in human cells
259554Rad50_P2A-HA-BSD_N-Donorfor RAD50-dTAG system
259555pLentiV2_sgRNA_ATMknock out ATM in human cells
259556pLentiV2_sgRNA_MUS81knock out MUS81 in human cells
259557pLentiV2_sgRNA_ERCC1knock out ERCC1 in human cells
259558pLentiV2_sgRNA_ERCC4knock out ERCC4/XPF in human cells
259559pLentiV2_sgRNA_HIRAknock out HIRA in human cells
259560pLentiV2_sgRNA_HLTFknock out HLTF in human cells
259561pLentiV2_sgRNA_ZRANB3knock out ZRANB3 in human cells

Antibodies from Article