A dynamic RNA hub facilitates activation-induced cytidine deaminase recruitment to the immunoglobulin heavy-chain locus.

Mikhova M, Kapanka M, Han L, Ungor G, Schmidt JC, Yu K
Mol Cell. 2026 Jun 23:S1097-2765(26)00383-7. doi: 10.1016/j.molcel.2026.06.012. PubMed Article

Plasmids from Article

ID	Plasmid	Purpose
259568	pLH280	Expressing PCP-super folder GFP fusion protein
259569	pLH349	Expressing tdMCP2-mScarlet fusion protein
259570	pLH353	Expressing PCP-super folder GFP fusion protein
259571	pLH303	Gene targeting vector for inserting 24xPP7 upstream of IgH switch alpha region
259572	pLH343	Gene targeting vector for inserting 24xMS2 upstream of IgH switch mu region
259573	pLH338	Gene targeting vector for inserting 24xPP7 downstream of IgH switch alpha region
259574	pLH299	RMCE exchange vector containing 24xPP7 and a mini switch alpha fragment
259575	pLH334	RMCE exchange vector containing 24xPP7
259576	pLH335	RMCE exchange vector containing 24xPP7 and an inverted mini switch alpha fragment
259577	pLH305	Gene targeting vector for inserting the HaloTag at the C-terminus of Aicda gene
259578	pLH319	Expressing the HaloTag
259579	pLH260	RMCE exchange vector containing most of Aicda intron 1 and coding sequences (WT)
259580	pLH272	RMCE exchange vector containing most of Aicda intron 1 and coding sequences (R190X)
259581	pLH275	RMCE exchange vector containing most of Aicda intron 1 and coding sequences (E58A)
259582	pLH276	RMCE exchange vector containing most of Aicda intron 1 and coding sequences (H56A)
259583	pLH260G133V	RMCE exchange vector containing most of Aicda intron 1 and coding sequences (G133V)
259584	pLH260R174S	RMCE exchange vector containing most of Aicda intron 1 and coding sequences (R174S)