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Angiotensin receptor conformations stabilized by biased ligands differentially modulate beta-arrestin interactions.

Elgeti M, Belyaeva J, Helabad MB, Staus DP, Wingler LM
J Biol Chem. 2026 Feb;302(2):111117. doi: 10.1016/j.jbc.2025.111117. Epub 2025 Dec 29. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
259690pMAL-His8-MBP-3C-dscFv30E. coli periplasmic expression of the active-state-specific beta-arrestin1 (arrestin2) antibody fragment dscFv30, with a 3C-cleavable N-terminal His8-Maltose Binding Protein fusion.
259691pGEX-GST-beta-arrestin1-393 (cysteine-free)E. coli expression of rat beta-arrestin1 (arrestin2) with endogenous cysteines removed and truncation at residue 393, with a thrombin-cleavable N-terminal glutathione S-transferase fusion.
259692Nb24-His6 (b-arrestin1 nanobody)E. coli periplasmic expression of the active-state-specific beta-arrestin1 (arrestin2) nanobody Nb24 with a C-terminal His6 tag

Antibodies from Article