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Editing DNA methylation in vivo.

Pan R, Ren J, Chen X, Flores LF, Gonzalez RVL, Adonnino AA, Lofts B, Waldo J, Halmai J, Devinsky O, Fink K, Liu XS
Nat Commun. 2025 Dec 10;17(1):527. doi: 10.1038/s41467-025-67222-5. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
259717AAV:ITR-U6-sgRNA(backbone)-pCBh-Cre-mCherry-KASH-WPRE-hGHpA-ITRExpresses sgRNA under U6 promoter and Cre recominase under Cbh promoter with mCherry-KASH nuclear envelope reporter and contains SapI cut sites for sgRNA cloning
259718AAV:ITR-U6-sgRNA(backbone)-hSyn-Cre-2A-mCherry-KASH-WPRE-PA-ITRExpresses sgRNA under U6 promoter and Cre recominase under hSyn promoter with mCherry-KASH nuclear envelope reporter and contains SapI cut sites for sgRNA cloning

Antibodies from Article