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An extracellular, optogenetic antibody platform for stimulus-gated antigen recognition and modulation of cell behavior.

Kwon E, Yu D, Yu J, Kim HJ, Jeong Y, Lee HK, Heo WD
Cell Chem Biol. 2026 Jun 18;33(6):848-861.e6. doi: 10.1016/j.chembiol.2026.04.006. Epub 2026 May 7. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
260315Igk-vGFP(N)-TM-nMagHigh-tBFPGFP targeting extrabody N-terminal fragment
260316Igk-vGFP(C)-TM-pMagHigh-Fusion RedGFP targeting extrabody C-terminal fragment
260317pHR-SFFV-vGFP(N)-synNotch-nMagHigh-TetRVP64GFP targeting extrabody-synNotch N-terminal fragment
260318pHR-SFFV-vGFP(C)-synNotch-pMagHigh-TetRVP64GFP targeting extrabody-synNotch C-terminal fragment
260319pLV-EF1a-vGFP(N)-IgG4H-CD8TM-nMagHigh-41BB-CD3z-tBFPGFP targeting extrabody-CAR N-terminal fragment
260320pLV-EF1a-vGFP(C)-IgG4H-CD8TM-pMagHigh-41BB-CD3z-Fusion RedGFP targeting extrabody-CAR C-terminal fragment
260322pLV-EF1a-vGFP(C)-IgG4H-CD8TM-pMagHigh-Fusion RedGFP targeting extrabody-CAR C-terminal fragment without 41BB CD3z domain

Antibodies from Article