Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging.
Plesa AM, Jung S, Wang HH, Omar F, Shadpour M, Choy Buentello D, Perez-Matos MC, Horwitz N, Cai G, Ngian ZK, Magalhaes C, Wagers AJ, Mair WB, Del Sol A, Church GM
Nat Aging. 2026 Oct;6(10):2057-2073. doi: 10.1038/s43587-026-01234-8. Epub 2026 Oct 14.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 261722 | PB-CT3G-ERP2-SRSF1 | Barcoded piggybac transposon vector with Dox-inducible expression of SRSF1 |
| 261723 | PB-CT3G-ERP2-BFP | Barcoded piggybac transposon vector with Dox-inducible expression of mTagBFP2 |
| 261724 | pAAV-CT3G-ER-MG | All-in-one AAV destination vector for dox-inducible expression of MegaGate-cloned elements (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked) |
| 261725 | pAAV-CT3G-ER-mSrsf1 | All-in-one AAV vector for dox-inducible expression of mouse Srsf1 (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked) |
| 261726 | pAAV-CT3G-ER-GFP | All-in-one AAV vector for dox-inducible expression of sfGFP (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked) |