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Transcriptomic reprogramming screen identifies SRSF1 as a regulator of aging

Plesa AM, Jung S, Wang HH, Omar F, Shadpour M, Buentello DC, Perez-Matos MC, Horwitz N, Cai G, Ngian ZK, Magalhaes C, Wagers AJ, Mair WB, del Sol A, Church GM
Nat Aging 6, 2057–2073 (2026) (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
261722PB-CT3G-ERP2-SRSF1Barcoded piggybac transposon vector with Dox-inducible expression of SRSF1
261723PB-CT3G-ERP2-BFPBarcoded piggybac transposon vector with Dox-inducible expression of mTagBFP2
261724pAAV-CT3G-ER-MGAll-in-one AAV destination vector for dox-inducible expression of MegaGate-cloned elements (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked)
261725pAAV-CT3G-ER-mSrsf1All-in-one AAV vector for dox-inducible expression of mouse Srsf1 (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked)
261726pAAV-CT3G-ER-GFPAll-in-one AAV vector for dox-inducible expression of sfGFP (EF-1α-driven Tet-On 3G, AAV2 ITR-flanked)

Antibodies from Article