Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING.
Ragland SA, Lindblad KE, Li Y, Choi JH, Okin D, Mao JQ, Richmond-Buccola D, Coronado DR, Brown MR, Snapper SB, Kranzusch PJ, Kagan JC
Immunity. 2026 Aug 11;59(8):2086-2105.e17. doi: 10.1016/j.immuni.2026.06.023. Epub 2026 Jul 17.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 261911 | pLentiCRISPRV2-murineIfnar1 | Use to generate Ifnar1 knockout |
| 261912 | pLentiCRISPRV2-murineIrf3 | Use to generate Irf3 knockout |
| 261913 | pLentiCRISPRV2-murineTbk1 | Use to generate Tbk1 knockout |
| 261914 | pLentiCRISPRV2-murineMavs | Use to generate Mavs knockout |
| 261915 | pLentiCRISPRV2-murineRip2 | Use to generate Rip2 knockout |
| 261916 | pLentiCRISPRV2-murineSting1 | Use to generate Sting1 knockout |
| 261917 | pLentiCRISPRV2-murinecGAS | Use to generate cGAS knockout |
| 261918 | pLentiCRISPRV2-murineSlc19a1 | Use to generate Slc19a1 knockout |
| 261919 | pLentiCRISPRV2-murineSlc46a1 | Use to generate Slc46a1 knockout |
| 261920 | pLentiCRISPRV2-murineSlc46a2 | Use to generate Slc46a2 knockout |
| 261921 | pLentiCRISPRV2-murineSlc46a3 | Use to generate Slc46a3 knockout |
| 261922 | pLentiCRISPRV2-murineLrrc8a-g1 | Use to generate Lrrc8a knockout |
| 261923 | pLentiCRISPRV2-murineLrrc8a-g2 | Use to generate Lrrc8a knockout |
| 261924 | pLentiCRISPRV2-murineLrrc8b | Use to generate Lrrc8b knockout |
| 261925 | pLentiCRISPRV2-murineLrrc8c | Use to generate Lrrc8c knockout |
| 261926 | pLentiCRISPRV2-murineLrrc8d | Use to generate Lrrc8d knockout |
| 261927 | pLentiCRISPRV2-murineLrrc8e | Use to generate Lrrc8e knockout |
| 261928 | pLentiCRISPRV2-humanSTING1 | Use to generate STING1 knockout |
| 261929 | pLentiCRISPRV2-humanCGAS | Use to generate CGAS knockout |
| 261930 | pLentiCRISPRV2-humanLRRC8A | Use to generate LRRC8A knockout |