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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA.
Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES
Nature. 2009 Mar 26;458(7237):509-13. doi: 10.1038/nature07710. Epub 2009 Jan 21.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
51522pET21a-hAIM2-deltaPYDExpress His6-tagged HIN domain of hAIM2 in bacteria
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51528pET21a-hAIM2-GSTExpress GST-tagged hAIM2 in bacteria
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51531pET21a-hAIM2-PYD-GSTExpress GST-tagged PYD of hAIM2 in bacteria
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51532pET21a-hAIM2-His6Express His6-tagged hAIM2 in bacteria
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51533pET21a-mAIM2-GSTExpress GST-tagged mAIM2 in bacteria
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51534pET21a-mAIM2-deltaPYD-GSTExpress GST-tagged HIN domain of mAIM2 in bacteria
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51535pET21a-mAIM2-deltaPYDExpress His6-tagged HIN domain of mAIM2 in bacteria
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51536pET21a-mAIM2-His6Express His6-tagged mAIM2 in bacteria
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51537pcDNA3-mAIM2-FlagExpress Flag-tagged mAIM2 in mammalian cells
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51538pcDNA3-hAIM2-T7Express T7-tagged hAIM2 in mammalian cells
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51539pcDNA3-hAIM2deltPYD-T7Express T7-tagged HIN domain of hAIM2 in mammalian cells
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51540pFlag-CMV2-mAIM2Express Flag-tagged mAIM2 in mammalian cells
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51541pEGFP-N1-T7-hAIM2Express T7 and GFP-tagged hAIM2 in mammalian cells
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51542pEGFP-N1-hAIM2Express GFP-tagged hAIM2 in mammalian cells
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51544pDsRed-monomer-hAIM2Express DsRed monomer-tagged hAIM2 in bacteria
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51608pMSCVpuro-T7-hAIM2-EGFPExpress T7 and GFP-tagged hAIM2 in mammalian cells
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51609pMSCVpuro-hAIM2-DsRed monomerExpress DsRed monomer-tagged hAIM2 in mammalian cells
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51610pMSCVpuro-mAIM2-PYD-EGFPExpress GFP-tagged PYD of mAIM2 in mammalian cells
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51666pRSCgfp-hAIM2Express GFP and hAIM2 in mammalian cells
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51667pMSCVpuro-Flag-mAIM2-EGFPExpress Flag and GFP-tagged mAIM2 in mammalian cells
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