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Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model.
Yang Z, Nakagawa K, Sarkar A, Maruyama J, Iwasa H, Bao Y, Ishigami-Yuasa M, Ito S, Kagechika H, Hata S, Nishina H, Abe S, Kitagawa M, Hata Y
Mol Cell Biol. 2014 Feb 18.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
52083pLenti-EF-FH-TAZ-ires-blastLentiviral expression vector for TAZ with N-terminal FLAG and HA tags
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52084pLenti-EF-FH-TAZ S89A-ires-blastLentiviral expression vector for TAZ S89A mutant with N-terminal FLAG and HA tags
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52085pLenti-EmGFP-LATS2/1 KDLentiviral RNAi vector for knockdown of LATS2 and LATS1. Co-expresses EmGFP as reporter
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