We narrowed to 187 results for: grna

1. hCRISPRi_dual_5_6

   Pooled Library

   #187248

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Jonathan Weissman, Marco Jost

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

2. hCRISPRi_dual_3_4

   Pooled Library

   #187247

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Jonathan Weissman, Marco Jost

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

3. hCRISPRa_dual_3_4

   Pooled Library

   #187250

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Jonathan Weissman, Marco Jost

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

4. hCRISPRa_dual_5_6

   Pooled Library

   #187251

   Purpose

   Ultra-compact, human genome-wide CRISPRi library targeting each gene with a single element encoding a dual sgRNA cassette.

   Depositor

   Jonathan Weissman, Marco Jost

   Article

   Replogle et al eLife. 2022 Dec 28;11:e81856. doi: 10.75

   Species

   Synthetic

   Use

   Lentiviral

   Available since

   Sept. 30, 2022

   Availability

   Academic Institutions and Nonprofits only

5. MinLibCas9

   Pooled Library

   #164896

   Purpose

   Human genome-wide CRISPR-Cas9 gRNA library, optimised by mining existing large-scale screening datasets, which provides a >60% reduction in size while preserving key information content

   Depositor

   Mathew Garnett

   Article

   Gonçalves et al Genome Biol. 2021 Jan 21;22(1):40. doi:

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   May 20, 2021

   Availability

   Academic Institutions and Nonprofits only

6. Human DNA Binding Domain-Focused CRISPR Knockout Library

   Pooled Library

   #123334

   Purpose

   Expresses gRNA targeting the DNA binding domain of human transcription factors.

   Depositor

   Christopher Vakoc

   Article

   Huang et al Genes Dev. 2018 Jul 1;32(13-14):915-928.

   Expression

   Mammalian

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   May 2, 2019

   Availability

   Academic Institutions and Nonprofits only

7. Human CRISPR Poison Exon Knockout Library

   Pooled Library

   #138084

   Purpose

   The human pgPoison library induces skipping of “poison” cassette exons and corresponding upstream constitutive exons by targeting 3' splice sites with paired gRNAs (pgRNAs).

   Depositor

   Robert Bradley

   Article

   Thomas et al Nat Genet. 2020 Jan;52(1):84-94. doi: 10

   Species

   Homo sapiens

   Use

   CRISPR and Lentiviral

   Available since

   March 6, 2020

   Availability

   Academic Institutions and Nonprofits only

8. mU6-CR1-CRISPRiv2_hU6-CR3-NT-ctrl-guide_EF1a-PuroR-T2A-BFP

   Pooled Library

   #197348

   Purpose

   To allow for genome-wide genetic modifier screening, the library has a second fixed non-targeting control guide.

   Depositor

   Jonathan Weissman, Rebecca Voorhees

   Article

   Guna et al BMC Genomics. 2023 Oct 30;24(1):651. doi

   Species

   Homo sapiens

   Use

   Lentiviral

   Available since

   May 25, 2023

   Availability

   Academic Institutions and Nonprofits only

9. mU6-CR1-CRISPRiv2_hU6-CR3-EMC2-guide_EF1a-PuroR-T2A-BFP

   Pooled Library

   #197349

   Purpose

   To allow for genome-wide genetic modifier screening, the library has a second fixed guide targeting EMC2.

   Depositor

   Jonathan Weissman, Rebecca Voorhees

   Article

   Guna et al BMC Genomics. 2023 Oct 30;24(1):651. doi

   Species

   Homo sapiens

   Use

   Lentiviral

   Available since

   May 25, 2023

   Availability

   Academic Institutions and Nonprofits only

10. Splicing-targeting CRISPR-Cas9 library for human lncRNAs

    Pooled Library

    #119977

    Purpose

    The CRISPR sgRNA library was designed to target the 5' or 3' splice sites of lncRNAs in genome-scale, in order to knockout the targeted lncRNAs.

    Depositor

    Wensheng Wei

    Article

    Liu et al Nat Biotechnol. 2018 Nov 5. pii: nbt.428

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    March 27, 2019

    Availability

    Academic Institutions and Nonprofits only

11. Oxford Drosophila melanogaster Genome-wide CRISPR Library

    Pooled Library

    #64750

    Purpose

    A genome-wide CRISPR library covering 13,501 genes (98.8% of the Drosophila melanogaster genome), among which 8,989 genes are targeted by three or more independent single guide RNAs (sgRNAs).

    Depositor

    Ji-Long Liu

    Article

    Bassett et al J Genet Genomics. 2015 Jun 20;42(6):301-

    Expression

    Insect

    Species

    Drosophila melanogaster, Streptococcus pyogenes, and Synthetic

    Use

    CRISPR

    Available since

    March 7, 2016

    Availability

    Academic Institutions and Nonprofits only

12. Liu Lab MusCK Library A

    Pooled Library

    #174196

    Purpose

    MusCK library contains 23,622 unique sgRNAs targeting 4,787 gene locations in the genome. Sub-library MusCK A contains 5 gRNAs per gene.

    Depositor

    Xiaole Shirley Liu

    Article

    Wang et al Cell. 2021 Oct 14;184(21):5357-5374.e22.

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    Oct. 29, 2021

    Availability

    Academic Institutions and Nonprofits only

13. Liu Lab MusCK Library B

    Pooled Library

    #174197

    Purpose

    MusCK library contains 23,622 unique sgRNAs targeting 4,787 gene locations in the genome. Sub-library MusCK M_b contains 5 gRNAs per gene.

    Depositor

    Xiaole Shirley Liu

    Article

    Wang et al Cell. 2021 Oct 14;184(21):5357-5374.e22.

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    Oct. 29, 2021

    Availability

    Academic Institutions and Nonprofits only

14. ALL-PAM sensor Library

    Pooled Library

    #179219

    Purpose

    10 human and mouse sgRNAs each where for each sgRNA the tethered target site has 1 of 64 possible 3 bp PAM sequences.

    Depositor

    Lukas Dow

    Article

    Sanchez-Rivera et al Nat Biotechnol. 2022 Feb 14. pii: 10.103

    Expression

    Mammalian

    Use

    Lentiviral

    Available since

    June 16, 2022

    Availability

    Academic Institutions and Nonprofits only

15. Human SLC KO Library

    Pooled Library

    #132552

    Purpose

    Expresses gRNAs for knockout of the human Solute Carrier family

    Depositor

    Giulio Superti-Furga

    Article

    Girardi et al Nat Chem Biol. 2020 Apr;16(4):469-478. d

    Expression

    Mammalian

    Species

    Homo sapiens

    Use

    CRISPR and Lentiviral

    Available since

    May 7, 2020

    Availability

    Academic Institutions and Nonprofits only

16. Mouse Liver CRISPR Knockout Library

    Pooled Library

    #192824

    Purpose

    CRISPR screening library containing ~72,000 sgRNAs

    Depositor

    Kristin Knouse

    Article

    Keys et al Cell Genom. 2022 Dec 14;2(12):100217. do

    Expression

    Mammalian

    Species

    Mus musculus

    Use

    CRISPR and Lentiviral

    Available since

    Dec. 1, 2022

    Availability

    Academic Institutions and Nonprofits only

17. LV2btCRISPRko.v1

    Pooled Library

    #213927

    Purpose

    Uses lentivirus to deliver the library into hard-to-transduce cells

    Depositor

    Wenfang Spring Tan

    Article

    Tan et al PLoS Pathog. 2023 Dec 6;19(12):e1011822.

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    April 9, 2024

    Availability

    Academic Institutions and Nonprofits only

18. PBbtCRISPRko.v1

    Pooled Library

    #213928

    Purpose

    Uses the PiggyBac transposon system to deliver the library into hard to transduce cells

    Depositor

    Wenfang Spring Tan

    Article

    Tan et al PLoS Pathog. 2023 Dec 6;19(12):e1011822.

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    April 9, 2024

    Availability

    Academic Institutions and Nonprofits only

19. Lourido Toxoplasma CRISPR Library V1

    Pooled Library

    #80636

    Purpose

    Plasmid sgRNA library containing ten guides against each of the 8,158 predicted Toxoplasma gondii protein coding genes.

    Depositor

    Sebastian Lourido

    Article

    Sidik et al Cell. 2016 Sep 8;166(6):1423-1435.e12. d

    Available since

    Sept. 19, 2016

    Availability

    Academic Institutions and Nonprofits only

20. RNA-binding protein pooled CRISPR knockout library

    Pooled Library

    #141438

    Purpose

    CRISPR knockout library targets RBPs with 10 sgRNAs/gene

    Depositor

    Eugene Yeo

    Article

    Wheeler et al Nat Methods. 2020 May 11. pii: 10.1038/s

    Expression

    Mammalian

    Use

    CRISPR and Lentiviral

    Available since

    May 28, 2020

    Availability

    Academic Institutions and Nonprofits only