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Addgene co-founder Melina Fan is transitioning to our Chief Scientific Advisor. We reflect on our history, how science has changed, and what comes next.

Learn what non-model organisms are, why scientists use them, and what they can teach us.

Learn how to navigate the PhD job market, from choosing between academia and industry to translating your skills and positioning yourself for the right role.

The REPROcode collection includes 408 barcoded lentiviral vectors carrying immune-specific transcription factors, allowing transdifferentiation screens.

High schoolers invented a new diagnostic for Lyme disease. In the process, they also created a tool for jointly designing RPA primers and Cas12a sgRNAs.

Learn about new tools in Addgene's collection, including new biosensors for neuroscience research, plasmids for a common lab enzyme, and more!

Addgene has a new brand identity! This post describes the design decisions that went into our new logo, style, introductory video, and our mascot, Blugene.

Synthetic origins of replication, or ORIs, from the Chappell Lab have improved plasmid compatibility and copy number control compared to natural ORIs.

This post, written by the creator of the CRISPRecise kit, explains how to use it to minimize off-target effects in CRISPR genome editing.

This post discusses takeaways from, and tools presented at, the Deaminet 2026 conference, focusing on base editors, prime editors, and translational work.

This post describes the development of sentinel plants, which change color to alert humans when they detect certain molecules in their environment.

Learn about hot new tools in our collection!

Learn about what's coming for Addgene in 2026

This post discusses the applications, advantages, and caveats to using hybrid guide RNAs, in which DNA bases are substituted for RNA bases.

This post highlights some of the tools Addgene makes available to industry scientists.

This post describes applications of pooled libraries, briefly explains several approaches, and highlights the most popular pooled libraries at Addgene.

Learn about new tools in Addgene's collection!

Learn about click biology and how you can use it to advance your experiments and explore biological phenomenon.

Learn more about NanoBiT technology and explore examples of HiBiT-tagged fusion proteins in action.

Baby KJ was treated for his devastating genetic disorder with CRISPR base editing. This post describes the prior advances that made his cure possible.