Optogenetics + CRISPR, Using Light to Control Genome Editing
Type
Blog Post
...blog post: Anti-CRISPR Proteins Switch Off CRISPR-Cas Systems.
Listen to the anti-CRISPR podcast segment... combined CRISPR and optogenetic techniques to develop a variety of photoactivatable CRISPR tools. These...optogenetic manipulation of CRISPR-based systems in animal models.
Use Anti-CRISPRs to Turn Off Genome Editing....
Stop light! Photoactive anti-CRISPRs halt Cas9 activity
Anti-CRISPR proteins are a highly diverse group...photoactivatable CRISPR strategies
Publication
System nickname
Photoactivatable moiety
Cas9 variatn
CRISPR protein...Light-Dependent Anti-CRISPR
Bubeck et al., 2018
CASANOVA
LOV2 from A. Sativa
AcrIIA4 anti-CRISPR protein, co-... D (2018) Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9. Nat Methods 15:924–927...