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We narrowed to 1,010 results for: RING;

Showing: 281 - 290 of 1010 results

  1. Trading Spaces - Visiting Scientist Edition

    Type
    Blog Post
    ... visiting scientist is distinct from equipment sharing or a collaboration – it requires re-location of...training so that you yourself can become an expert and bring the knowledge back to your home lab. Alternatively...the conversation. Many researchers are open to sharing knowledge and establishing collaborations, so it...if they have specialized skills and equipment! Preparing for your visit   Design and communicate a research...mentor or anyone else available to directly help you during your visit. Reach out to your bench mentor (if ...and rights for anything that could be generated during the visit. If you don’t feel comfortable initiating...travels! Resources Resources on the Addgene blog Fostering communication in remote collaborations Transferable...

  2. Predicting Adverse Reactions to Monoclonal Antibody Drugs

    Type
    Blog Post
    ... body recognizes a drug as a foreign antigen, triggering a humoral immune response. ADAs can inactivate...inactivate the drug and increase drug clearance, lowering its efficacy and increasing the risk of an adverse ...on the immunogenicity of the drug product while ensuring the safety and the efficacy.  Better together ...determining the T-cell epitopes that will likely bring about unwanted immunogenicity. The 3-D models can...Monoclonal Antibodies in Macaca fascicularis: From Manufacturing to Preclinical Studies. In J. Bluemel, S. Korte...10.1634/theoncologist.2016-0061WHO. International monitoring of adverse reactions to drugs: adverse reaction...WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden, 1992. Mattei, A. E., Gutierrez...

  3. Advice for Scientists Starting a Lab

    Type
    Blog Post
    ... Connie Cepko points out the limited choices in hiring graduate students and postdocs when starting out...counter-productive." He also emphasizes the point to “encourage sharing - in part by having projects ambitious enough that...position, start studying up before you begin the hiring process. Read Genevive Bjorn's "Ready, Set, Hire...Nature Jobs for some quick advice and resources for hiring research staff. And for a more indepth resource...experiments and grant writing. You have to enjoy the mentoring role.” She points out that new PIs may not recognize...student or postdoc may require different types of mentoring. Some mentees prefer lots of advice and micromanagement... interdisciplinary, with emphasis on genetic engineering, sequencing, and translation of results to companies...

  4. A Guide to Getting Started in Undergrad Research

    Type
    Blog Post
    ...world of academic research can be quite daunting. During my first year of college, I knew I wanted to try... four years after I started college, I will be entering a PhD program to continue my scientific endeavors...met graduate students who enjoy the thrill of acquiring a piece of knowledge before anyone else in the...neurodegenerative disease because they had close relatives suffering from similar diseases. Others were inspired by...biofuel production. There’s a lot out there worth exploring! Being excited about the science allows you to...proactive Rather than applying only to posted job offerings, the best research experiences typically come ... provided me with much-needed emotional support during my journey. When you are hunting for labs to join...

  5. Plasmid Tools for Microbiome Studies

    Type
    Blog Post
    ...take a look at a few of these methods below. Engineering gut microbes in situ While the ability to monitor... University developed a method for genetically altering gut microbiome members in their native habitat...reporter gene. The hairpin blocks translation by sequestering the RBS, but binding of the “trigger RNA” (in... Counting cell division in the gut microbiota Monitoring microbial population dynamics in the gut can ...one bright particle that segregates into one cell during cell division. To achieve the agglomeration of ...References Leonard, Sean P., et al. "Genetic engineering of bee gut microbiome bacteria with a toolkit...PMC4674677. Ronda, Carlotta, et al. "Metagenomic engineering of the mammalian gut microbiome in situ." Nature...

  6. Announcing the Winners of the 2021 Michael Davidson and Roger Tsien Commemorative Conference Awards

    Type
    Blog Post
    ... neurons using GCaMP7, measuring calcium signaling related fluorescence during morphine administration... neurons at specific firing frequencies. She hopes to identify how in vivo firing frequency of PV neurons...researchers attend a conference of their choice while honoring the late Michael Davidson and Roger Tsien who ...iGluSnFR3 (left). GluSnFR3 in pMinDisplay (PDGFR anchoring domain), in electroporated in rat hippocampal ...modulate protein activity and have important roles during oxidative stress. To monitor this activity, Pedre...

  7. Summer SciComm: Preprints

    Type
    Blog Post
    ...allow authors to avoid many of these issues, by sharing their work publicly and immediately once the manuscript...emerging COVID-19 pandemic quickly and openly. By sharing results faster and more broadly, scientists can...evidence of their productivity that can be shared with hiring and review committees, as opposed to the opaque.... Preprints at Addgene Preprints are all about sharing scientific knowledge faster and more openly — which...open-science organizations, we support scientists in sharing their results and materials with the broader community...in a preprint provides all the same benefits as sharing those plasmids alongside a journal article, but...He also posted two preprints of his own research during his PhD studies.  References and Additional Resources...

  8. CRISPR Meets Synthetic Biology: A Conversation with MIT’s Christopher Voigt

    Type
    Blog Post
    ... genetic engineering, with the ultimate objective of genome design.” It’s genetic engineering on a genomic...toolbox needed for anyone to begin considering genetic engineering projects in a very big way. In one ...scale could be created. Someone could take on an engineering project including hundreds of genes and regulation...complete toolbox for taking on very large genetic engineering projects. Addgene: How easy is it to do this ...animals make. That will be an outcome of genetic engineering.   Thank you to Chris Voigt for speaking with...

  9. Typing CRISPR Systems

    Type
    Blog Post
    ...2023). Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering. Science...interest in bacterial and archaeal immune systems. During this time, scientists discovered many related immune...keep increasing, as efforts using large-scale clustering and discovery algorithms find new candidates ... L. A., & Zhang, F. (2013). Multiplex genome engineering using CRISPR/CAS systems. Science, 339(6121),...1027. https://doi.org/10.1126/science.aaq0180 Harrington, L. B., Burstein, D., Chen, J. S., Paez-Espino..., K. V. (2021). Type III CRISPR-CAS systems: deciphering the most complex prokaryotic immune system. Biochemistry...(2015). Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity. Cell, 161(5), 1164...

  10. Hot Plasmids May 2018 - Optogenetics, Decaffeination, Biosensors, and Fluorescent Protein Tools

    Type
    Blog Post
    ...CRY2, although some studies have shown that this clustering only happens under certain conditions. With...drawback of this method is the stray excitation of neighboring neurons in opsin dense regions. To overcome this...able to demonstrate that while illumination of neighboring cells evokes action potentials (APs) in patched...this operon can serve as a living biosensor for measuring caffeine content in samples. The Barrick lab and...concentrations in several beverages could be estimated by measuring growth of the ΔguaB pDCAF3 strain. Find the decaffeination...placesTagRFP-T and Dronpa in close proximity. By monitoring changes in TagRFP-T fluorescence intensity at...the authors tracked protein activity while also capturing information about spatial and temporal organization...
Showing: 281 - 290 of 1010 results