To Codon Optimize or Not: That is the Question
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Blog Post
...synthesis relies on transfer RNAs (tRNAs). tRNAs bind to and deliver amino acids to the ribosome where...complementary to the mRNA sequence. The 3’ end of the tRNA binds the amino acid that corresponds to the anticodon...1980s, scientists even created a codon adaptation index (CAI) that is based on the codon usage frequency...https://doi.org/10.1038/nsmb1031
Gustafsson C, Govindarajan S, Minshull J (2004) Codon bias and heterologous...nrg3051
Sharp PM, Li W-H (1987) The codon adaptation index-a measure of directional synonymous codon usage ...