A New Generation of Adenine Base Editors Improves Editing in Primary Human Cells
Type
Blog Post
...adenine base editors with improved editing in cell lines
Nicole Gaudelli, the Associate Director and Head ...Adenine base editors (ABE) mediate A•T-to-G•C base changes (Figure 1), but it can be challenging to make...to create the eighth generation of adenine base editors, called ABE8 (Gaudelli et al., 2020). The generated...to increase the targeting scope of adenine base editors
The most commonly used S. pyogenes Cas9 requires...targeting scope for base editing.
Try ABE8 base editors for your research!
Base editing in primary human...human cells
Cell therapy approaches can use base editors to correct mutations in stem cells and return the...Reducing off-target editing in ABE8s
While base editors are precise molecular tools, they do have undesired...