We narrowed to 1,010 results for: RING;

1. Antibodies 101: Affinity Reagents

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   ...similar to a Fab fragment but created through engineering instead of cleavage. They are comprised of the...stable up to 80°C and can refold correctly after denaturing.  Designed ankyrin repeat proteins, or DARPins...

2. Plasmids 101: Cre-lox

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   ...enough that there is virtually no chance of it occurring randomly. Therefore, inserting loxP sites at deliberate...are active only in certain cell or tissue types, during certain stages of development, or by making the...

3. BeHeard Award 2018: Diseases of Glycosylation, Arginine Mutagenesis, & Neural Development

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   ...features that allow such “chemical rescue” in vivo. Engineering the human disease alleles into cells for testing...might consider prescribing GdnHCl to patients suffering from rare diseases arising from Arg mutations....

4. Rabies and Neuronal Tracing

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   ...specific locations and give rise to progenitors during growth and development or that blood flows through.... While the EnvA genetic sequences are supplied during production of EnvA-pseudotyped RABV, these sequences...

5. Adeno Associated Virus (AAV) for Cell and Gene Therapy

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   ...hold great promise for improving or potentially curing human diseases that were previously thought to ...as gene delivery tools: Unlike most naturally occurring viruses used in clinical trials, wild type AAV...

6. Plasmids 101: The Wide World of Natural Plasmids

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   ...spread. They can be inherited by daughter cells during cellular reproduction, similar to the host’s chromosome...metabolic pathways. Fertility (F) plasmids: microbial sharing F plasmids contain the genes for bacteria to form...

7. Nanoblades: Tiny CRISPR Ninjas for Genome Editing Difficult Cells

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   ...CRISPR is a simple and versatile tool for genome engineering, but its utility is dependent on its ability ...Nanoblades editing efficiencies of primary cells. Comparing Nanoblades to Existing CRISPR Delivery Methods...

8. Antibodies 101: Choosing the Right Isotype

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   ...options are available to you, it may be worth considering an antibody raised in a different species.    ... strategically plan primary/secondary antibody pairing such that each target has a unique species or isotype...

9. A New Generation of Adenine Base Editors Improves Editing in Primary Human Cells

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   ...resulted altogether in 40 new ABE8 variants. When comparing on-target DNA editing efficiency in a human cell...and ABE7.10. They quantified genomic editing by measuring the reduction in protein expression of these six...

10. Savvy Advocates Needed to Navigate a Scientific Enterprise in Flux

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    ... of Research (FoR) symposia held across the USA during this time have revealed that young scientists are...Biochemistry and Molecular Biology/ FoR Hack Day during which several projects were initiated. Recent developments...