We narrowed to 3 results for: crbn

...bifunctional degraders co-opt E3 ligases such as cereblon (CRBN) or von Hippel-Lindau (VHL) to bring the endogenous...: We synthesized dTAG molecules by conjugating a CRBN-binding ligand (thalidomide) to an FKBP12F36V binding...-substrates Small molecule degraders may recruit CRBN to nonstandard or “neo-substrates.” We advise evaluation...

...the FKPB12F36V fusion protein with the endogenous CRBN E3 ligase complex which will polyubiquitinate the...FKBP12F36V fused target protein-of-interest and the CRBN E3 ligase complex leading to ubiquitination and ...

...cereblon (CRBN), including popular new approaches like PROTAC targeted protein degraders. But CRBN has been... of Alessio Ciulli and collaborators developed CRBNmidi (Kroupova et al., 2024). This construct contains...      Figure 2: Crystal structures of CRBNmidi alone (A) and in a ternary complex with the multiple...2024). They were able to study and crystallize CRBNmidi on its own, with drug ligands, and in ternary ...ternary complexes with other proteins, establishing CRBNmidi as a promising tool for future structure-guided...protein ubiquitination and degradation.   Find the CRBNmidi plasmid here!   Kroupova, A. et al. (2024). Design...