...and mTORC2. Each complex contains a unique subunit: raptor for mTORC1, and rictor for mTORC2. Background...Background mTORC1 & mTORC2 The better-characterized mTORC1 responds to various signals, including amino...processes including autophagy and lysosome biogenesis. mTORC2 does not respond to nutrients, but it is activated...activated by growth factors, including insulin. mTORC2 influences cell survival and cytoskeletal organization...Impact Enhanced signaling through either mTORC1 or mTORC2 correlates with poor prognosis in many cancers,...both pro-proliferative and anti-apoptotic signals. mTORC2, which appears to signal upstream of Akt, also ...Von Hippel-Lindau tumor suppressor Return to top mTORC2 Complex Symbol Name AKT AKT1 AKT2 AKT3 v-akt murine...