...choice to ensure that there are no toxicities at the doses used to evaluate degradation of the FKBP12F36V-fusion... observed little to no toxicity with dTAG-13 at doses as high as 20 µM (see Figures 3 and 5 in Nabet et...See our recent papers noted below for examples of dose-responses and time-courses (Nabet et al., Erb et...

...into the bloodstream, but requires a high vector dose and is unable to reach all regions of the CNS. PHP.B...similar transduction efficiency, but at a log lower dose than PHP.B.  A Ly6a variant is linked to PHP.B CNS...gene transfer to the rat CNS: AAV PHP. EB vector dose–response and comparison to AAV PHP. B." Gene therapy...

...initial paper, we used MUCICAT to optimize the gene dosage of glucose dehydrogenase and generated a strain...higher cargo copy numbers. (D) The effect of gene dosage on N-acetylglucosamine concentration. Image from...construct a strain library with different gene dosages to facilitate swift optimization of strains. Multiple...

...that these issues can be mitigated by using low doses and running appropriate controls (Jendryka et al...molecules (PSEMs). Higher potency means lower drug doses, which decreases the risk of off target effects....

...p24 ELISA dosing method detects the expression of viral capsid antigen p24, the FACS dosing method correlates...

...situ before being injected back into the body in 3 doses intravenously. B cells and T cells activated ex ...leukaemia in children and young adults: a phase 1 dose-escalation trial." The Lancet 385.9967 (2015): 517...

...Daniel Mejías Sánchez, ¡y no podríamos estar más emocionados! Después de recibir la traducción, Addgene contrató...

...serotype specific In our study we observed that low doses of sucrose improve AAV2 yields approximately 1.8...

...of biologic product, mode of administration, and dose (Lu et.al., 2020).  Evaluating a drug’s immunogenicity...

...different plasmid, which may lead to unequal gene dosage and high variability of protein coexpression. By...

...facilitate our aims to correct X chromosome gene dosage in TS cells as a first step to reverse the developmental...

...SCD in 2022 as well. Hereditary transthyretin amyloidosis (hATTR) hATTR is caused by a variety of single...

...-3 to proliferate. The cells cultured with a low dose of IL-3 showed reduced proliferation and had a greater...

...presence of the poly(A) tail targets the RNA to the degradosome, which contains enzymes that cut RNA not protected...

...CRISPRa is well-suited, including studying mRNA dosing effects, cellular reprogramming, and disease modeling...

...Servellita V, Singh J, Miao X, Streithorst JA, Granados A, Sotomayor-Gonzalez A, Zorn K, Gopez A, Hsu ...

..., Cogan, J. Z., Replogle, J. M., Adriaens, C., Ramadoss, G. N., Shi, Q., Hung, K. L., Samelson, A. J.,...

...commonly used vector cargo designs and administration doses. Don't forget to submit your validation data after...

...to remove salt, then suspend a freshly harvested dose of cells (preferably in log phase) in blocking solution...

...Choudhary A (2019) A Singular System with Precise Dosing and Spatiotemporal Control of CRISPR‐Cas9. Angew...