We narrowed to 156 results for: hwa

... exploiting the homology-directed repair (HDR) pathway which occurs in cells at low frequencies and relies...A, A>G, and T>C) installation by base editors. Pathways that compete with the desired outcome are not ...

...and more, often driven by Rho family signaling pathways. Rho guanine-nucleotide exchange factors (GEFs...phosphatidic acid signaling (such as Hippo, AMPK and mTOR pathways) and to introduce unnatural head groups for applications...

...repaired by the nonhomologous end-joining (NHEJ) pathway, leading to nonspecific nucleotide insertions, ...homology-directed repair (HDR), a distinct cellular DNA repair pathway. Accomplishing this usually involves simultaneously...

...then cleaved by RISC and degraded. In the miRNA pathway, RISC doesn’t always cleave the mRNA — the bound...Comparison of shRNA and miRNA processing and silencing pathways. Created on BioRender.com.   Expressing shRNAs...

...genome editing. The homology-directed repair (HDR) pathway is downregulated in mature tissues - no problem... through the non-homologous end joining (NHEJ) pathway. It’s estimated that very little dystrophin correction...

...silencing pathways: transcriptional and post-transcriptional gene silencing (PTGS). In either pathway, short...

...body, or they can be used to activate cellular pathways by binding to cell surface receptors. These applications...are typically used for investigating signaling pathways or developing therapeutics. Experimentally, antibodies...

...approved monoclonal antibodies targeting the PD-L1 pathway, VEGF production, and CTLA4 and CD protein blocking...Research Cancer Drug Resistance Checkout the RAS Pathway Clone Collection ...

...because the non-homologous end-joining (NHEJ) repair pathway is not very robust. In many cases, homology-directed...natural products. To easily explore and engineer pathways within this genus, Huimin Zhao’s lab created two...

...efficiency of homology-directed repair (HDR), the pathway for resolving DNA double-strand breaks (DSBs) preferred..., P., Lee, K. D., Ortega, M. A., Sawyer, C., Schwaegerle, N. D., Peraro, L., Young, L., Lee, S.-J., Ciaramella...

...public and private partners to create additional pathways for critical scientific work to continue.  Moving...

...use in basic biology, for example, by targeting pathways underlying cancer or other disease processes. ...

...understand how a given gene is involved in a complex pathway. Some of the most heavily-studied genes in cancer...

... that routes the protein through the secretory pathway to improve folding and disulfide bond formation...

...What led you to it? Howarth: Our collaborator Uli Schwarz-Linek at St. Andrews discovered the domain. It ...

...activates the immune system's classical complement pathway, starting a cascade of events that results in the...

... References Lorsch JR, Collins FS, Lippincott-Schwartz J. Cell biology. Fixing problems with cell lines...

...specific stimulus. While the escape response neural pathway is well characterized, there is much left to be...

...Mapping the brainDissecting circuits Studying GPCR pathways   Acknowledgements We thank the Bryan Roth...

...nearly infinite regulatory capabilities of gene pathways just waiting to be discovered. As we started building...