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Showing: 1 - 2 of 2 results
  1. New Tools Enable CRISPRa for Neuroscience Applications

    Type
    Blog Post
    Published
    July 2, 2019, 12:51 p.m.
    ...immediate-early gene Bdnf, which encodes brain-derived neurotrophic factor (BDNF). Bdnf is expressed early...and Bdnf IV-overexpressing neurons. Among the upregulated genes common between the Bdnf I and Bdnf IV ... The Bdnf gene possesses 9 distinct transcriptional start sites, all of which yield the same BDNF protein... expression of Bdnf resulted in hundreds of differentially expressed genes between Bdnf I-overexpressing...achieved with CRISPRa, the Day lab singled out two Bdnf isoforms (I and IV) for investigation. Co-transduction...
  2. Deciphering the Mysteries of Behavior with Viral Vectors

    Type
    Blog Post
    Published
    Sept. 17, 2019, 12:40 p.m.
    ...focuses on brain derived neurotrophic factor (BDNF). BDNF is a small protein involved in neurogenesis, ...relevance of BDNF in depression. The researchers found that injecting lentiviral vectors expressing BDNF in the...synaptic plasticity. Several studies have found reduced BDNF levels within the hippocampus and frontal cortex...miR124a, a regulatory RNA that negatively regulates BDNF levels. They found that downregulating expression...25657248. Groves, J. O. "Is it time to reassess the BDNF hypothesis of depression?." Molecular psychiatry...
Showing: 1 - 2 of 2 results