New Tools Enable CRISPRa for Neuroscience Applications
Type
Blog Post
Published
July 2, 2019, 12:51 p.m.
...immediate-early gene Bdnf, which encodes brain-derived neurotrophic factor (BDNF). Bdnf is expressed early...and Bdnf IV-overexpressing neurons. Among the upregulated genes common between the Bdnf I and Bdnf IV ... The Bdnf gene possesses 9 distinct transcriptional start sites, all of which yield the same BDNF protein... expression of Bdnf resulted in hundreds of differentially expressed genes between Bdnf I-overexpressing...achieved with CRISPRa, the Day lab singled out two Bdnf isoforms (I and IV) for investigation. Co-transduction...