..., Chrimson, ChrimsonR, Chronos Inhibitory (Hyperpolarizing) ChR Variants. Alternatively, ChR variants ...chloride channels, these variants result in the hyperpolarization of neurons. Examples of anion channel variants...NpHR (from Natronomonas pharaoni ), causes hyperpolarization (inhibition) of the cell when triggered with... a light-activated outward proton pump that hyperpolarizes (inhibits) the cell when triggered by green-yellow...

...spectrum of single-nucleotide variants (somatic hypermutation) in a larger editing window. These systems are...REPAIR , developed by the Feng Zhang lab , used a hyperactive adenosine deaminase that acts on RNA, ADAR2(E488Q...Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells. Nature Methods . 13 (12)...