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pLJM1-EGFP Citations (117)

Plasmid Article: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM Science. 2008 Jun 13. 320(5882):1496-501.
PubMed Journal

Articles Citing pLJM1-EGFP

Articles
Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity. Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R. Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. PubMed
Lentiviral overexpression of miRNAs. Zollner H, Hahn SA, Maghnouj A. Methods Mol Biol. 2014;1095:177-90. doi: 10.1007/978-1-62703-703-7_15. PubMed
A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation. Dennis MK, Mogridge J. Biochemistry. 2014 Apr 8;53(13):2166-71. doi: 10.1021/bi5000756. Epub 2014 Mar 25. PubMed
Myogenesis defect due to Toca-1 knockdown can be suppressed by expression of N-WASP. George B, Jain N, Fen Chong P, Hou Tan J, Thanabalu T. Biochim Biophys Acta. 2014 Sep;1843(9):1930-41. doi: 10.1016/j.bbamcr.2014.05.008. Epub 2014 May 24. PubMed
Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8. Jiang Y, Yan B, Lai W, Shi Y, Xiao D, Jia J, Liu S, Li H, Lu J, Li Z, Chen L, Chen X, Sun L, Muegge K, Cao Y, Tao Y. Oncogene. 2015 Mar 9. doi: 10.1038/onc.2015.53. PubMed
Tumors escape CD4+ T cell-mediated immunosurveillance by impairing the ability of infiltrating macrophages to indirectly present tumor antigens. Tveita AA, Schjesvold F, Haabeth OA, Fauskanger MH, Bogen B. Cancer Res. 2015 Jun 2. pii: canres.3640.2014. PubMed
CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18. Chu HW, Rios C, Huang C, Wesolowska-Andersen A, Burchard EG, O'Connor BP, Fingerlin TE, Nichols D, Reynolds SD, Seibold MA. Gene Ther. 2015 Jul 2. doi: 10.1038/gt.2015.53. PubMed
Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth. Ta HQ, Ivey ML, Frierson HF Jr, Conaway MR, Dziegielewski J, Larner JM, Gioeli D. Cancer Res. 2015 Dec 1;75(23):5093-105. doi: 10.1158/0008-5472.CAN-15-0224. Epub 2015 Nov 16. PubMed
The NAD salvage pathway modulates cancer cell viability via p73. Sharif T, Ahn DG, Liu RZ, Pringle E, Martell E, Dai C, Nunokawa A, Kwak M, Clements D, Murphy JP, Dean C, Marcato P, McCormick C, Godbout R, Gujar SA, Lee PW. Cell Death Differ. 2015 Nov 20. doi: 10.1038/cdd.2015.134. PubMed
Using Sensors and Generators of H2O2 to Elucidate the Toxicity Mechanism of Piperlongumine and Phenethyl Isothiocyanate. Huang BK, Langford TF, Sikes HD. Antioxid Redox Signal. 2016 Jun 1;24(16):924-38. doi: 10.1089/ars.2015.6482. PubMed
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, Van Hemelrijck M, Cao Y, Condeelis J, Hynes RO, Gertler FB, Krause M. Oncogene. 2016 Mar 21. doi: 10.1038/onc.2016.47. PubMed
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis. Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, Zuo X, Liu Y, Luo K, Song W, Wang K, Pang M. Neoplasia. 2016 Apr;18(4):242-52. doi: 10.1016/j.neo.2016.03.001. PubMed
TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. Santos AJ, Nogueira C, Ortega-Bellido M, Malhotra V. J Cell Biol. 2016 May 9;213(3):343-54. doi: 10.1083/jcb.201603072. Epub 2016 May 2. PubMed
Whole organism lineage tracing by combinatorial and cumulative genome editing. McKenna A, Findlay GM, Gagnon JA, Horwitz MS, Schier AF, Shendure J. Science. 2016 May 26. pii: aaf7907. PubMed

Associated Plasmids

Vitamin C promotes pluripotency of human induced pluripotent stem cells via the histone demethylase JARID1A. Eid W, Abdel-Rehim W. Biol Chem. 2016 Nov 1;397(11):1205-1213. doi: 10.1515/hsz-2016-0181. PubMed
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. Sborgi L, Ruhl S, Mulvihill E, Pipercevic J, Heilig R, Stahlberg H, Farady CJ, Muller DJ, Broz P, Hiller S. EMBO J. 2016 Aug 15;35(16):1766-78. doi: 10.15252/embj.201694696. Epub 2016 Jul 14. PubMed
Modulating and Measuring Intracellular H2O2 Using Genetically Encoded Tools to Study Its Toxicity to Human Cells. Huang BK, Stein KT, Sikes HD. ACS Synth Biol. 2016 Dec 16;5(12):1389-1395. Epub 2016 Jul 26. PubMed
Localized translation regulates cell adhesion and transendothelial migration. Bergeman J, Caillier A, Houle F, Gagne LM, Huot ME. J Cell Sci. 2016 Nov 1;129(21):4105-4117. Epub 2016 Sep 16. PubMed
A new functional IDH2 genetic variant is associated with the risk of lung cancer. Li J, Lu J, He Y, Wu Y, Wu Y, Song X, Jiang Y, Tang M, Weng X, Yi W, Luo X, Sun L, Bode AM, Cao Y. Mol Carcinog. 2016 Sep 20. doi: 10.1002/mc.22573. PubMed
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Mol Cell. 2016 Oct 6;64(1):163-175. doi: 10.1016/j.molcel.2016.08.023. Epub 2016 Sep 22. PubMed
Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia. Lam SS, Ho ES, He BL, Wong WW, Cher CY, Ng NK, Man CH, Gill H, Cheung AM, Ip HW, So CC, Tamburini J, So CW, Ho DN, Au CH, Chan TL, Ma ES, Liang R, Kwong YL, Leung AY. Sci Transl Med. 2016 Oct 5;8(359):359ra129. PubMed
In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1alpha Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model. Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS. Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):184-194. doi: 10.1016/j.ijrobp.2016.09.005. Epub 2016 Sep 14. PubMed
DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells. Hainer SJ, McCannell KN, Yu J, Ee LS, Zhu LJ, Rando OJ, Fazzio TG. Elife. 2016 Nov 16;5. pii: e21964. doi: 10.7554/eLife.21964. PubMed
WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels. Salvi A, Thanabalu T. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1353-1359. doi: 10.1016/j.bbrc.2016.12.040. Epub 2016 Dec 7. PubMed
Expression of tamoxifen-inducible CRE recombinase in Lcn5-CreERT2 transgenic mouse caput epididymis. Xu J, Yao G, Ru Y, Xie S. Mol Reprod Dev. 2016 Dec 28. doi: 10.1002/mrd.22772. PubMed
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPbeta and Modulating Its Transcriptional Activity. Luo X, Ryu KW, Kim DS, Nandu T, Medina CJ, Gupte R, Gibson BA, Soccio RE, Yu Y, Gupta RK, Kraus WL. Mol Cell. 2017 Jan 19;65(2):260-271. doi: 10.1016/j.molcel.2016.11.015. PubMed
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing. Golden RJ, Chen B, Li T, Braun J, Manjunath H, Chen X, Wu J, Schmid V, Chang TC, Kopp F, Ramirez-Martinez A, Tagliabracci VS, Chen ZJ, Xie Y, Mendell JT. Nature. 2017 Feb 9;542(7640):197-202. doi: 10.1038/nature21025. Epub 2017 Jan 23. PubMed

Associated Plasmids

Efficient in vivo gene editing using ribonucleoproteins in skin stem cells of recessive dystrophic epidermolysis bullosa mouse model. Wu W, Lu Z, Li F, Wang W, Qian N, Duan J, Zhang Y, Wang F, Chen T. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1660-1665. doi: 10.1073/pnas.1614775114. Epub 2017 Jan 30. PubMed
Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing. Bianco C, Mohr I. J Virol. 2017 Apr 13;91(9). pii: JVI.02483-16. doi: 10.1128/JVI.02483-16. Print 2017 May 1. PubMed
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. Suresh S, Durakoglugil D, Zhou X, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA. PLoS Genet. 2017 Mar 8;13(3):e1006650. doi: 10.1371/journal.pgen.1006650. eCollection 2017 Mar. PubMed
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A Jr, Lewis CA, Sabatini DM. Cell. 2017 Apr 6;169(2):258-272.e17. doi: 10.1016/j.cell.2017.03.023. PubMed

Associated Plasmids

Proteolytic control of the mitochondrial calcium uniporter complex. Tsai CW, Wu Y, Pao PC, Phillips CB, Williams C, Miller C, Ranaghan M, Tsai MF. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4388-4393. doi: 10.1073/pnas.1702938114. Epub 2017 Apr 10. PubMed
Targeting Insulin Receptor in Breast Cancer Using Small Engineered Protein Scaffolds. Chan JY, Hackel BJ, Yee D. Mol Cancer Ther. 2017 Jul;16(7):1324-1334. doi: 10.1158/1535-7163.MCT-16-0685. Epub 2017 May 3. PubMed
Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension. Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB. Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790. PubMed
Low levels of physiological interstitial flow eliminate morphogen gradients and guide angiogenesis. Shirure VS, Lezia A, Tao A, Alonzo LF, George SC. Angiogenesis. 2017 Jun 12. doi: 10.1007/s10456-017-9559-4. PubMed
An engineered protein antagonist of K-Ras/B-Raf interaction. Kauke MJ, Traxlmayr MW, Parker JA, Kiefer JD, Knihtila R, McGee J, Verdine G, Mattos C, Wittrup KD. Sci Rep. 2017 Jul 19;7(1):5831. doi: 10.1038/s41598-017-05889-7. PubMed
DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12-CXCR4 signaling axis. Chang AH, Raftrey BC, D'Amato G, Surya VN, Poduri A, Chen HI, Goldstone AB, Woo J, Fuller GG, Dunn AR, Red-Horse K. Genes Dev. 2017 Aug 4. pii: gad.301549.117. doi: 10.1101/gad.301549.117. PubMed
Identification of novel ALK2 inhibitors and their effect on cancer cells. Kim M, Choi O, Pyo S, Choi SU, Park CH. Biochem Biophys Res Commun. 2017 Oct 7;492(1):121-127. doi: 10.1016/j.bbrc.2017.08.016. Epub 2017 Aug 4. PubMed
The Display of Single-Domain Antibodies on the Surfaces of Connectosomes Enables Gap Junction-Mediated Drug Delivery to Specific Cell Populations. Gadok AK, Zhao C, Meriwether AI, Ferrati S, Rowley TG, Zoldan J, Smyth HDC, Stachowiak JC. Biochemistry. 2018 Jan 9;57(1):81-90. doi: 10.1021/acs.biochem.7b00688. Epub 2017 Sep 1. PubMed
Niche-derived laminin-511 promotes midbrain dopaminergic neuron survival and differentiation through YAP. Zhang D, Yang S, Toledo EM, Gyllborg D, Salto C, Carlos Villaescusa J, Arenas E. Sci Signal. 2017 Aug 22;10(493). pii: 10/493/eaal4165. doi: 10.1126/scisignal.aal4165. PubMed
Expression of N-WASP is regulated by HiF1alpha through the hypoxia response element in the N-WASP promoter. Salvi A, Thanabalu T. Biochem Biophys Rep. 2016 Nov 9;9:13-21. doi: 10.1016/j.bbrep.2016.10.010. eCollection 2017 Mar. PubMed
Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28. PubMed
Phase-Separated Liposomes Enhance the Efficiency of Macromolecular Delivery to the Cellular Cytoplasm. Imam ZI, Kenyon LE, Ashby G, Nagib F, Mendicino M, Zhao C, Gadok AK, Stachowiak JC. Cell Mol Bioeng. 2017 Oct;10(5):387-403. doi: 10.1007/s12195-017-0489-4. Epub 2017 May 22. PubMed
MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells. Lee MH, Koh D, Na H, Ka NL, Kim S, Kim HJ, Hong S, Shin YK, Seong JK, Lee MO. Autophagy. 2018;14(5):812-824. doi: 10.1080/15548627.2017.1388476. Epub 2018 Jan 15. PubMed
Live imaging analysis of human gastric epithelial spheroids reveals spontaneous rupture, rotation and fusion events. Sebrell TA, Sidar B, Bruns R, Wilkinson RA, Wiedenheft B, Taylor PJ, Perrino BA, Samuelson LC, Wilking JN, Bimczok D. Cell Tissue Res. 2018 Feb;371(2):293-307. doi: 10.1007/s00441-017-2726-5. Epub 2017 Nov 25. PubMed
Spindle associated membrane protein 1 (Samp1) is required for the differentiation of muscle cells. Jafferali MH, Figueroa RA, Hasan M, Hallberg E. Sci Rep. 2017 Nov 30;7(1):16655. doi: 10.1038/s41598-017-16746-y. PubMed
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification. Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J. Cell Stem Cell. 2018 Feb 1;22(2):191-205.e9. doi: 10.1016/j.stem.2017.11.016. Epub 2017 Dec 28. PubMed

Associated Plasmids

Development of a functionalized UV-emitting nanocomposite for the treatment of cancer using indirect photodynamic therapy. Sengar P, Juarez P, Verdugo-Meza A, Arellano DL, Jain A, Chauhan K, Hirata GA, Fournier PGJ. J Nanobiotechnology. 2018 Feb 27;16(1):19. doi: 10.1186/s12951-018-0344-3. PubMed
A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53. Mao C, Wang X, Liu Y, Wang M, Yan B, Jiang Y, Shi Y, Shen Y, Liu X, Lai W, Yang R, Xiao D, Cheng Y, Liu S, Zhou H, Cao Y, Yu W, Muegge K, Yu H, Tao Y. Cancer Res. 2018 Jul 1;78(13):3484-3496. doi: 10.1158/0008-5472.CAN-17-3454. Epub 2018 Mar 27. PubMed
A novel heme oxygenase-1 splice variant, 14kDa HO-1, promotes cell proliferation and increases relative telomere length. Bian C, Zhong M, Nisar MF, Wu Y, Ouyang M, Bartsch JW, Zhong JL. Biochem Biophys Res Commun. 2018 Jun 2;500(2):429-434. doi: 10.1016/j.bbrc.2018.04.096. Epub 2018 Apr 19. PubMed
A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness. di Gennaro A, Damiano V, Brisotto G, Armellin M, Perin T, Zucchetto A, Guardascione M, Spaink HP, Doglioni C, Snaar-Jagalska BE, Santarosa M, Maestro R. Cell Death Differ. 2018 Dec;25(12):2165-2180. doi: 10.1038/s41418-018-0103-x. Epub 2018 Apr 17. PubMed
A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling. Kauke MJ, Tisdale AW, Kelly RL, Braun CJ, Hemann MT, Wittrup KD. Mol Cancer Ther. 2018 Aug;17(8):1773-1780. doi: 10.1158/1535-7163.MCT-17-0645. Epub 2018 May 2. PubMed
CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Huang LC, Tam KW, Liu WN, Lin CY, Hsu KW, Hsieh WS, Chi WM, Lee AW, Yang JM, Lin CL, Lee CH. Dis Markers. 2018 Apr 12;2018:3835783. doi: 10.1155/2018/3835783. eCollection 2018. PubMed
Kaposi's Sarcoma-Associated Herpesvirus ORF68 Is a DNA Binding Protein Required for Viral Genome Cleavage and Packaging. Gardner MR, Glaunsinger BA. J Virol. 2018 Jul 31;92(16). pii: JVI.00840-18. doi: 10.1128/JVI.00840-18. Print 2018 Aug 15. PubMed
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks. Dionne U, Chartier FJM, Lopez de Los Santos Y, Lavoie N, Bernard DN, Banerjee SL, Otis F, Jacquet K, Tremblay MG, Jain M, Bourassa S, Gish GD, Gagne JP, Poirier GG, Laprise P, Voyer N, Landry CR, Doucet N, Bisson N. Mol Cell. 2018 Jun 21;70(6):995-1007.e11. doi: 10.1016/j.molcel.2018.05.013. Epub 2018 Jun 18. PubMed
Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Garri C, Howell S, Tiemann K, Tiffany A, Jalali-Yazdi F, Alba MM, Katz JE, Takahashi TT, Landgraf R, Gross ME, Roberts RW, Kani K. Oncotarget. 2018 Jun 8;9(44):27363-27379. doi: 10.18632/oncotarget.25221. eCollection 2018 Jun 8. PubMed
Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells. Darnell AM, Subramaniam AR, O'Shea EK. Mol Cell. 2018 Jul 19;71(2):229-243.e11. doi: 10.1016/j.molcel.2018.06.041. PubMed
Overexpression of GRB2 Enhances Epithelial to Mesenchymal Transition of A549 Cells by Upregulating SNAIL Expression. Mitra P, Kalailingam P, Tan HB, Thanabalu T. Cells. 2018 Aug 7;7(8). pii: cells7080097. doi: 10.3390/cells7080097. PubMed
Monitoring the action of redox-directed cancer therapeutics using a human peroxiredoxin-2-based probe. Langford TF, Huang BK, Lim JB, Moon SJ, Sikes HD. Nat Commun. 2018 Aug 7;9(1):3145. doi: 10.1038/s41467-018-05557-y. PubMed

Associated Plasmids

The NAD(+) Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis. Murphy JP, Giacomantonio MA, Paulo JA, Everley RA, Kennedy BE, Pathak GP, Clements DR, Kim Y, Dai C, Sharif T, Gygi SP, Gujar S. Cell Rep. 2018 Aug 28;24(9):2381-2391.e5. doi: 10.1016/j.celrep.2018.07.086. PubMed
Anoctamin 5/TMEM16E facilitates muscle precursor cell fusion. Whitlock JM, Yu K, Cui YY, Hartzell HC. J Gen Physiol. 2018 Nov 5;150(11):1498-1509. doi: 10.1085/jgp.201812097. Epub 2018 Sep 26. PubMed
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C. Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012. Epub 2018 Oct 4. PubMed
Establishment of stably expandable induced myogenic stem cells by four transcription factors. Lee EJ, Kim M, Kim YD, Chung MJ, Elfadl A, Ulah HMA, Park D, Lee S, Park HS, Kim TH, Hwang D, Jeong KS. Cell Death Dis. 2018 Oct 25;9(11):1092. doi: 10.1038/s41419-018-1114-8. PubMed
Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids. Shirure VS, Bi Y, Curtis MB, Lezia A, Goedegebuure MM, Goedegebuure SP, Aft R, Fields RC, George SC. Lab Chip. 2018 Dec 7;18(23):3687-3702. doi: 10.1039/c8lc00596f. Epub 2018 Nov 5. PubMed
The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth. Cardoso C, Serafim RB, Kawakami A, Goncalves Pereira C, Roszik J, Valente V, Vazquez VL, Fisher DE, Espreafico EM. Pigment Cell Melanoma Res. 2019 Mar;32(2):303-314. doi: 10.1111/pcmr.12751. Epub 2018 Dec 16. PubMed
BAR scaffolds drive membrane fission by crowding disordered domains. Snead WT, Zeno WF, Kago G, Perkins RW, Richter JB, Zhao C, Lafer EM, Stachowiak JC. J Cell Biol. 2019 Feb 4;218(2):664-682. doi: 10.1083/jcb.201807119. Epub 2018 Nov 30. PubMed
Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ. J Clin Invest. 2019 Feb 1;129(2):694-711. doi: 10.1172/JCI120606. Epub 2019 Jan 14. PubMed
Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma. Liu L, Wu Y, Bian C, Nisar MF, Wang M, Hu X, Diao Q, Nian W, Wang E, Xu W, Zhong JL. Cell Commun Signal. 2019 Jan 11;17(1):3. doi: 10.1186/s12964-018-0313-3. PubMed
Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays. Zhou W, Duan M, Fu W, Pang J, Tang Q, Sun H, Xu L, Chang S, Li D, Hou T. Genomics Proteomics Bioinformatics. 2018 Dec;16(6):416-427. doi: 10.1016/j.gpb.2018.03.007. Epub 2019 Jan 9. PubMed
Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation by Inhibiting the Akt Pathway. Kalailingam P, Tan HB, Pan JY, Tan SH, Thanabalu T. Cells. 2019 Feb 2;8(2). pii: cells8020117. doi: 10.3390/cells8020117. PubMed
Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen. Shortt K, Heruth DP, Zhang N, Wu W, Singh S, Li DY, Zhang LQ, Wyckoff GJ, Qi LS, Friesen CA, Ye SQ. Sci Rep. 2019 Feb 4;9(1):1396. doi: 10.1038/s41598-018-37940-6. PubMed
RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding. Krois CR, Vuckovic MG, Huang P, Zaversnik C, Liu CS, Gibson CE, Wheeler MR, Obrochta KM, Min JH, Herber CB, Thompson AC, Shah ID, Gordon SP, Hellerstein MK, Napoli JL. Cell Mol Life Sci. 2019 Jun;76(12):2425-2447. doi: 10.1007/s00018-019-03046-z. Epub 2019 Feb 20. PubMed
LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer. Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. Nature. 2019 May;569(7755):275-279. doi: 10.1038/s41586-019-1126-2. Epub 2019 Apr 17. PubMed
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043. PubMed
Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise trophoblast-endometrium cross-talk. Neradugomma NK, Drafton K, Mor GG, Mao Q. Reprod Toxicol. 2019 Aug;87:100-107. doi: 10.1016/j.reprotox.2019.05.064. Epub 2019 May 30. PubMed
Intranasal administration with recombinant Bacillus subtilis induces strong mucosal immune responses against pseudorabies. Wang J, Wang Y, Zhang E, Zhou M, Lin J, Yang Q. Microb Cell Fact. 2019 Jun 7;18(1):103. doi: 10.1186/s12934-019-1151-8. PubMed
MCPyV Large T antigen induced atonal homolog 1 (ATOH1) is a lineage-dependency oncogene in Merkel cell carcinoma. Fan K, Gravemeyer J, Ritter C, Rasheed K, Gambichler T, Moens U, Shuda M, Schrama D, Becker JC. J Invest Dermatol. 2019 Jul 5. pii: S0022-202X(19)31853-6. doi: 10.1016/j.jid.2019.06.135. PubMed
CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells. Milenkovic VM, Slim D, Bader S, Koch V, Heinl ES, Alvarez-Carbonell D, Nothdurfter C, Rupprecht R, Wetzel CH. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133359. doi: 10.3390/ijms20133359. PubMed
The Kaposi's Sarcoma-Associated Herpesvirus Protein ORF42 Is Required for Efficient Virion Production and Expression of Viral Proteins. Butnaru M, Gaglia MM. Viruses. 2019 Aug 2;11(8). pii: v11080711. doi: 10.3390/v11080711. PubMed
Functionalized erythrocyte-derived optical nanoparticles to target ephrin-B2 ligands. Hanley T, Yin R, Mac J, Tan W, Anvari B. J Biomed Opt. 2019 Aug;24(8):1-9. doi: 10.1117/1.JBO.24.8.085002. PubMed
RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Burke JM, Moon SL, Matheny T, Parker R. Mol Cell. 2019 Sep 19;75(6):1203-1217.e5. doi: 10.1016/j.molcel.2019.07.029. Epub 2019 Sep 4. PubMed
Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions. Hoffman HK, Fernandez MV, Groves NS, Freed EO, van Engelenburg SB. J Biol Chem. 2019 Nov 1;294(44):16266-16281. doi: 10.1074/jbc.RA119.009372. Epub 2019 Sep 13. PubMed
Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma. Suen HC, Qian Y, Liao J, Luk CS, Lee WT, Ng JKW, Chan TTH, Hou HW, Li I, Li K, Chan WY, Feng B, Gao L, Jiang X, Liu YH, Rudd JA, Hobbs R, Qi H, Ng TK, Mak HK, Leung KS, Lee TL. Stem Cells Dev. 2019 Oct 15;28(20):1365-1375. doi: 10.1089/scd.2019.0060. Epub 2019 Oct 3. PubMed
Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies. Krohn L, Ozturk TN, Vanderperre B, Ouled Amar Bencheikh B, Ruskey JA, Laurent SB, Spiegelman D, Postuma RB, Arnulf I, Hu MTM, Dauvilliers Y, Hogl B, Stefani A, Monaca CC, Plazzi G, Antelmi E, Ferini-Strambi L, Heidbreder A, Rudakou U, Cochen De Cock V, Young P, Wolf P, Oliva P, Zhang XK, Greenbaum L, Liong C, Gagnon JF, Desautels A, Hassin-Baer S, Montplaisir JY, Dupre N, Rouleau GA, Fon EA, Trempe JF, Lamoureux G, Alcalay RN, Gan-Or Z. Ann Neurol. 2020 Jan;87(1):139-153. doi: 10.1002/ana.25629. Epub 2019 Nov 18. PubMed
CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation. Cook NL, Pjanic M, Emmerich AG, Rao AS, Hetty S, Knowles JW, Quertermous T, Castillejo-Lopez C, Ingelsson E. BMC Endocr Disord. 2019 Oct 29;19(1):115. doi: 10.1186/s12902-019-0442-8. PubMed
Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Carter RJ, Milani M, Butterworth M, Alotibi A, Harper N, Yedida G, Greaves G, Al-Zebeeby A, Jorgensen AL, Schache AG, Risk JM, Shaw RJ, Jones TM, Sacco JJ, Hurlstone A, Cohen GM, Varadarajan S. Cell Death Dis. 2019 Dec 4;10(12):912. doi: 10.1038/s41419-019-2150-8. PubMed
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA, Sears PR, Black KE, Hariri LP, Almogarri I, Frenkel EM, Vinarsky V, Omran H, Knowles MR, Tearney GJ, Alkuraya FS, Sabatini DM. Nat Med. 2020 Jan 20. pii: 10.1038/s41591-019-0730-x. doi: 10.1038/s41591-019-0730-x. PubMed

Associated Plasmids

Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies. Nachtigal AL, Milenkovic A, Brandl C, Schulz HL, Duerr LMJ, Lang GE, Reiff C, Herrmann P, Kellner U, Weber BHF. Int J Mol Sci. 2020 Feb 26;21(5). pii: ijms21051597. doi: 10.3390/ijms21051597. PubMed
Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia. He BL, Yang N, Man CH, Ng NK, Cher CY, Leung HC, Kan LL, Cheng BY, Lam SS, Wang ML, Zhang CX, Kwok H, Cheng G, Sharma R, Ma AC, So CW, Kwong YL, Leung AY. EMBO Mol Med. 2020 Apr 7;12(4):e10895. doi: 10.15252/emmm.201910895. Epub 2020 Mar 5. PubMed
p75NTR(-/-) mice exhibit an alveolar bone loss phenotype and inhibited PI3K/Akt/beta-catenin pathway. Wang Y, Yang K, Li G, Liu R, Liu J, Li J, Tang M, Zhao M, Song J, Wen X. Cell Prolif. 2020 Apr;53(4):e12800. doi: 10.1111/cpr.12800. Epub 2020 Mar 25. PubMed
Specialization for Cell-Free or Cell-to-Cell Spread of BAC-Cloned Human Cytomegalovirus Strains Is Determined by Factors beyond the UL128-131 and RL13 Loci. Schultz EP, Lanchy JM, Day LZ, Yu Q, Peterson C, Preece J, Ryckman BJ. J Virol. 2020 Jun 16;94(13). pii: JVI.00034-20. doi: 10.1128/JVI.00034-20. Print 2020 Jun 16. PubMed
A VHH-Based Anti-MUC1 Chimeric Antigen Receptor for Specific Retargeting of Human Primary T Cells to MUC1-Positive Cancer Cells. Rajabzadeh A, Rahbarizadeh F, Ahmadvand D, Kabir Salmani M, Hamidieh AA. Cell J. 2021 Jan;22(4):502-513. doi: 10.22074/cellj.2021.6917. Epub 2020 Apr 22. PubMed
Intramitochondrial proteostasis is directly coupled to alpha-synuclein and amyloid beta1-42 pathologies. Lautenschlager J, Wagner-Valladolid S, Stephens AD, Fernandez-Villegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GS. J Biol Chem. 2020 Jul 24;295(30):10138-10152. doi: 10.1074/jbc.RA119.011650. Epub 2020 May 8. PubMed
Maternal Anti-Dengue IgG Fucosylation Predicts Susceptibility to Dengue Disease in Infants. Thulin NK, Brewer RC, Sherwood R, Bournazos S, Edwards KG, Ramadoss NS, Taubenberger JK, Memoli M, Gentles AJ, Jagannathan P, Zhang S, Libraty DH, Wang TT. Cell Rep. 2020 May 12;31(6):107642. doi: 10.1016/j.celrep.2020.107642. PubMed
DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification. Lentini JM, Alsaif HS, Faqeih E, Alkuraya FS, Fu D. Nat Commun. 2020 May 19;11(1):2510. doi: 10.1038/s41467-020-16321-6. PubMed
Efficient Nonviral Stable Transgenesis Mediated by Retroviral Integrase. Chiang CY, Ligunas GD, Chin WC, Ni CW. Mol Ther Methods Clin Dev. 2020 May 3;17:1061-1070. doi: 10.1016/j.omtm.2020.04.020. eCollection 2020 Jun 12. PubMed
ABL Genomic Editing Sufficiently Abolishes Oncogenesis of Human Chronic Myeloid Leukemia Cells In Vitro and In Vivo. Chen SH, Hsieh YY, Tzeng HE, Lin CY, Hsu KW, Chiang YS, Lin SM, Su MJ, Hsieh WS, Lee CH. Cancers (Basel). 2020 May 29;12(6). pii: cancers12061399. doi: 10.3390/cancers12061399. PubMed
Five transcriptional factors reprogram fibroblast into myogenic lineage cells via paraxial mesoderm stage. Hwang M, Lee EJ, Chung MJ, Park S, Jeong KS. Cell Cycle. 2020 Jul;19(14):1804-1816. doi: 10.1080/15384101.2020.1780384. Epub 2020 Jun 17. PubMed
Single point mutations within the Coxsackie B virus receptor-binding site promote resistance against soluble virus receptor traps. Pinkert S, Kopp A, Bruckner V, Fechner H, Beling A. J Virol. 2020 Jul 15. pii: JVI.00952-20. doi: 10.1128/JVI.00952-20. PubMed
The Autophagy Machinery Contributes to E-cadherin Turnover in Breast Cancer. Damiano V, Spessotto P, Vanin G, Perin T, Maestro R, Santarosa M. Front Cell Dev Biol. 2020 Jun 30;8:545. doi: 10.3389/fcell.2020.00545. eCollection 2020. PubMed
KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. NAR Cancer. 2020 Jun;2(2):zcaa007. doi: 10.1093/narcan/zcaa007. Epub 2020 May 18. PubMed
Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells. Muscarella AM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, Zhang XH. NPJ Breast Cancer. 2020 Sep 7;6:42. doi: 10.1038/s41523-020-00183-8. eCollection 2020. PubMed
A system-level approach identifies HIF-2alpha as a critical regulator of chondrosarcoma progression. Kim H, Cho Y, Kim HS, Kang D, Cheon D, Kim YJ, Chang MJ, Lee KM, Chang CB, Kang SB, Kang HG, Kim JH. Nat Commun. 2020 Oct 6;11(1):5023. doi: 10.1038/s41467-020-18817-7. PubMed
A novel kinase inhibitor, LZT-106, downregulates Mcl-1 and sensitizes colorectal cancer cells to BH3 mimetic ABT-199 by targeting CDK9 and GSK-3beta signaling. Yu Z, Du J, Zhao Y, Gao Y, Li Y, Zhao K, Lu N. Cancer Lett. 2021 Feb 1;498:31-41. doi: 10.1016/j.canlet.2020.10.001. Epub 2020 Oct 28. PubMed
Metformin inhibits proliferation of oral squamous cell carcinoma cells by suppressing proteolysis of nerve growth factor receptor. Wei J, Huang J, Kuang Y, Li Y, Zhong D, Song J. Arch Oral Biol. 2021 Jan;121:104971. doi: 10.1016/j.archoralbio.2020.104971. Epub 2020 Nov 7. PubMed
BRD2 regulation of sigma-2 receptor upon cholesterol deprivation. Shen H, Li J, Xie X, Yang H, Zhang M, Wang B, Kent KC, Plutzky J, Guo LW. Life Sci Alliance. 2020 Nov 24;4(1). pii: 4/1/e201900540. doi: 10.26508/lsa.201900540. Print 2021 Jan. PubMed
The p75(NTR) and its carboxyl-terminal fragment exert opposing effects on melanoma cell proliferation and apoptosis via modulation of the NF-kappaB pathway. Zhong M, Wang Y, Muhammad FN, Gao J, Bian C. FEBS Open Bio. 2021 Jan;11(1):226-236. doi: 10.1002/2211-5463.13047. Epub 2020 Dec 16. PubMed
A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover. Moreno H, Rastrojo A, Pryce R, Fedeli C, Zimmer G, Bowden TA, Gerold G, Kunz S. PLoS Negl Trop Dis. 2020 Dec 28;14(12):e0009004. doi: 10.1371/journal.pntd.0009004. eCollection 2020 Dec. PubMed
C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Ozawa T, Kaneko S, Szulzewsky F, Qiao Z, Takadera M, Narita Y, Kondo T, Holland EC, Hamamoto R, Ichimura K. Acta Neuropathol Commun. 2021 Mar 8;9(1):36. doi: 10.1186/s40478-021-01135-4. PubMed
Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation. Liu Y, Zou L, Wang P, Zhou J, Yuan C, Wang J. Exp Ther Med. 2021 Apr;21(4):363. doi: 10.3892/etm.2021.9794. Epub 2021 Feb 14. PubMed
A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. Commun Biol. 2021 Mar 25;4(1):399. doi: 10.1038/s42003-021-01929-1. PubMed
METTL3 mediates bone marrow mesenchymal stem cell adipogenesis to promote chemoresistance in acute myeloid leukaemia. Pan ZP, Wang B, Hou DY, You RL, Wang XT, Xie WH, Huang HF. FEBS Open Bio. 2021 Jun;11(6):1659-1672. doi: 10.1002/2211-5463.13165. Epub 2021 May 20. PubMed
Generation and Characterization of a CRISPR/Cas9-Mediated SNAP29 Knockout in Human Fibroblasts. Martens MC, Edelkamp J, Seebode C, Schafer M, Stahlke S, Krohn S, Jung O, Murua Escobar H, Emmert S, Boeckmann L. Int J Mol Sci. 2021 May 18;22(10). pii: ijms22105293. doi: 10.3390/ijms22105293. PubMed
Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. ACS Sens. 2021 Jun 8. doi: 10.1021/acssensors.0c02318. PubMed

Associated Plasmids

Anti-Tumor Effects of BDH1 in Acute Myeloid Leukemia. Han F, Zhao H, Lu J, Yun W, Yang L, Lou Y, Su D, Chen X, Zhang S, Jin H, Li X, Sun J, Huang H, Wang Q, Jiang X. Front Oncol. 2021 Jun 4;11:694594. doi: 10.3389/fonc.2021.694594. eCollection 2021. PubMed
A T cell redirection platform for co-targeting dual antigens on solid tumors. Enderle L, Shalaby KH, Gorelik M, Weiss A, Blazer LL, Paduch M, Cardarelli L, Kossiakoff A, Adams JJ, Sidhu SS. MAbs. 2021 Jan-Dec;13(1):1933690. doi: 10.1080/19420862.2021.1933690. PubMed
The structural dynamics of macropinosome formation and PI3-kinase-mediated sealing revealed by lattice light sheet microscopy. Quinn SE, Huang L, Kerkvliet JG, Swanson JA, Smith S, Hoppe AD, Anderson RB, Thiex NW, Scott BL. Nat Commun. 2021 Aug 10;12(1):4838. doi: 10.1038/s41467-021-25187-1. PubMed

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