The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM
Science. 2008 Jun 13. 320(5882):1496-501.
PubMed
Journal
Plasmids from Related Articles
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by...
Cell. 2010 Apr 16. 141(2):290-303.
26631: pLKO.1 p18 shRNA,
26632: pLKO.1 MP1 shRNA,
26633: pLJM1 Flag Raptor,
26634: pLJM1 Flag Raptor Rheb15,
26637: pLJM1 Flag Raptor HRas25 ...
- PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Mol Cell. 2007 Mar 23. 25(6):903-15.
14950: pRK5 Flag PRAS40,
14951: pRK5 HA GST Rheb1,
14952: pRK5 HA GST rap2a,
15511: HA GST PreScission p70 S6K1 ...
- PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.
J Biol Chem. 2007 Jul 6. 282(27):20036-44.
15672: PRAS40 (mouse) shRNA,
15673: HA PRAS40 F129A,
15674: HA PRAS40 S183A,
15675: HA PRAS40 P185A ...
-
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as ...
Curr Biol. 2003 Aug 5. 13(15):1259-68.
15888: pRK7-Rheb,
15889: pGEX-4T2-Rheb ...
