Human CRISPR Metabolic Gene Knockout Library Citations (11)
Originally described in: An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM Cell. 2015 Jul 30;162(3):540-51. doi: 10.1016/j.cell.2015.07.016. PubMed Journal
Articles Citing Human CRISPR Metabolic Gene Knockout Library
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SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism.
Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, Chan SH, Lewis CA, Wang T, Keys HR, Guo YE, Sabatini DM.
Science. 2018 Nov 16;362(6416). pii: 362/6416/eaat9528. doi: 10.1126/science.aat9528.
PubMed
Associated Plasmids |
| The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. Shang M, Yang H, Yang R, Chen T, Fu Y, Li Y, Fang X, Zhang K, Zhang J, Li H, Cao X, Gu J, Xiao J, Zhang Q, Liu X, Yu Q, Wang T. Nat Commun. 2021 Mar 29;12(1):1940. doi: 10.1038/s41467-021-22173-5. PubMed |
| CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors. Li H, Liu Y, Xiao Y, Wilson CN, Bai HJ, Jones MD, Wang S, DeVore JE, Maier EY, Durant ST, Boufraqech M, Weyemi U. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2212072120. doi: 10.1073/pnas.2212072120. Epub 2023 Feb 1. PubMed |
| The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage. Rivera-Mejias P, Narbona-Perez AJ, Hasberg L, Kroczek L, Bahat A, Lawo S, Folz-Donahue K, Schumacher AL, Ahola S, Mayer FC, Giavalisco P, Nolte H, Lavandero S, Langer T. Cell Rep. 2023 Mar 31;42(4):112332. doi: 10.1016/j.celrep.2023.112332. PubMed |
| Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors. Wang X, Su S, Zhu Y, Cheng X, Cheng C, Chen L, Lei A, Zhang L, Xu Y, Ye D, Zhang Y, Li W, Zhang J. Nat Commun. 2023 Sep 18;14(1):5778. doi: 10.1038/s41467-023-41470-9. PubMed |
| SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity. Wang F, Gao Y, Xue S, Zhao L, Jiang H, Zhang T, Li Y, Zhao C, Wu F, Siqin T, Liu Y, Wu J, Yan Y, Yuan J, Jiang JD, Li K. Nat Commun. 2023 Sep 22;14(1):5917. doi: 10.1038/s41467-023-41593-z. PubMed |
| AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis. Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q. Cell Death Dis. 2024 Mar 23;15(3):233. doi: 10.1038/s41419-024-06577-x. PubMed |
| Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer. Cheng C, Hu J, Mannan R, Bhattacharyya R, Rossiter NJ, Magnuson B, Wisniewski JP, Zheng Y, Xiao L, Li C, Awad D, He T, Bao Y, Zhang Y, Cao X, Wang Z, Mehra R, Morlacchi P, Sahai V, di Magliano MP, Shah YM, Ding K, Qiao Y, Lyssiotis CA, Chinnaiyan AM. bioRxiv [Preprint]. 2024 Mar 20:2024.03.18.585580. doi: 10.1101/2024.03.18.585580. PubMed |
| Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production. Sharrow AC, Megill E, Chen AJ, Farooqi A, McGonigal S, Hempel N, Snyder NW, Buckanovich RJ, Aird KM. bioRxiv [Preprint]. 2024 Jul 14:2024.07.12.603313. doi: 10.1101/2024.07.12.603313. PubMed |
| SLC7A5 is required for cancer cell growth under arginine-limited conditions. Dunlap KN, Bender A, Bowles A, Bott AJ, Tay J, Grossmann AH, Rutter J, Ducker GS. Cell Rep. 2025 Jan 28;44(1):115130. doi: 10.1016/j.celrep.2024.115130. Epub 2025 Jan 3. PubMed |
| Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair. Chiang JC, Shang Z, Rosales T, Cai L, Chen WM, Cai F, Vu H, Minna JD, Ni M, Davis AJ, Timmerman RD, DeBerardinis RJ, Zhang Y. Sci Adv. 2025 Mar 14;11(11):eadt1241. doi: 10.1126/sciadv.adt1241. Epub 2025 Mar 12. PubMed |
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