hCathepsin B Citations (13)

Originally described in: SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H J Biol Chem. 2006 Feb 10;281(6):3198-203. doi: 10.1074/jbc.M508381200. Epub 2005 Dec 8. PubMed Journal

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Articles Citing hCathepsin B

Articles
Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. Mizunoe Y, Sudo Y, Okita N, Hiraoka H, Mikami K, Narahara T, Negishi A, Yoshida M, Higashibata R, Watanabe S, Kaneko H, Natori D, Furuichi T, Yasukawa H, Kobayashi M, Higami Y. Autophagy. 2017 Apr 3;13(4):642-653. doi: 10.1080/15548627.2016.1274850. Epub 2017 Jan 25. PubMed
The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen. Luong B, Schwenk R, Brautigam J, Muller R, Menche D, Bischoff I, Furst R. PLoS One. 2018 Sep 11;13(9):e0203053. doi: 10.1371/journal.pone.0203053. eCollection 2018. PubMed
Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts. Chen CH, Bhasin S, Khanna P, Joshi M, Joslin PM, Saxena R, Amin S, Liu S, Sindhu S, Walker SR, Catalano P, Frank DA, Alper SL, Bhasin M, Bhatt RS. Oncogenesis. 2019 Feb 22;8(3):15. doi: 10.1038/s41389-019-0121-7. PubMed
Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology. Wang Y, Xu C, Ma L, Mou Y, Zhang B, Zhou S, Tian Y, Trinh J, Zhang X, Li XJ. Life Sci Alliance. 2019 Mar 25;2(2). pii: 2/2/e201800268. doi: 10.26508/lsa.201800268. Print 2019 Apr. PubMed
Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes. Mizunoe Y, Kobayashi M, Hoshino S, Tagawa R, Itagawa R, Hoshino A, Okita N, Sudo Y, Nakagawa Y, Shimano H, Higami Y. Sci Rep. 2020 Jan 20;10(1):634. doi: 10.1038/s41598-020-57428-6. PubMed
The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro. Han L, Xu D, Xi Z, Wu M, Nik Nabil WN, Zhang J, Sui H, Fu W, Zhou H, Lao Y, Xu G, Guo C, Xu H. Front Pharmacol. 2020 Dec 17;11:564833. doi: 10.3389/fphar.2020.564833. eCollection 2020. PubMed
Clickable, selective, and cell-permeable activity-based probe of human cathepsin B - Minimalistic approach for enhanced selectivity. Bhuiyan AI, Rathod P, Ghoshal S, Dana D, Das T, Li G, Dickson AA, Rafi F, Subramaniam GS, Fath KR, Paroly S, Chang EJ, Pathak SK. Bioorg Chem. 2021 Dec;117:105463. doi: 10.1016/j.bioorg.2021.105463. Epub 2021 Nov 2. PubMed
Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity. Kim MJ, Jeong H, Krainc D. Hum Mol Genet. 2022 Jul 21;31(14):2424-2437. doi: 10.1093/hmg/ddac047. PubMed
Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D. Huang P, Cao Q, Xu M, Dong XP. Cells. 2022 Mar 4;11(5). pii: cells11050887. doi: 10.3390/cells11050887. PubMed
Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. Gutierrez-Ruiz OL, Johnson KM, Krueger EW, Nooren RE, Cruz-Reyes N, Heppelmann CJ, Hogenson TL, Fernandez-Zapico ME, McNiven MA, Razidlo GL. Cell Rep. 2023 Sep 26;42(9):113042. doi: 10.1016/j.celrep.2023.113042. Epub 2023 Aug 30. PubMed
Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization. Pastorio C, Noettger S, Nchioua R, Zech F, Sparrer KMJ, Kirchhoff F. iScience. 2023 Oct 27;26(11):108299. doi: 10.1016/j.isci.2023.108299. eCollection 2023 Nov 17. PubMed
Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity. Pandey SP, Yang D, Hedden L, Laughlin CR, Wang W, Soto AS, Winner H, Medina Sanchez L, Campana EE, Engl C, Zeng Y, Rana M, Van Der Kraak L, Bender MJ, Prokopec J, Ferrick JM, Meng X, Fong E, Sun M, Mullett SJ, MacDonald M, Gelhaus SL, Watkins SC, Meisel M, von Moltke J, Xu S, Gong YN, Hinterleitner R. Immunity. 2025 Oct 14;58(10):2439-2455.e8. doi: 10.1016/j.immuni.2025.06.018. Epub 2025 Jul 22. PubMed
Production of human cathepsins using Expi293 mammalian cell expression system for off-target activity of cysteine protease inhibitor screening. Turner Z, Arutyunova E, Bui DT, Han L, Kandadai AS, Bai B, Young HS, Mahal LK, Klassen JS, Lemieux MJ. Protein Sci. 2025 Nov;34(11):e70361. doi: 10.1002/pro.70361. PubMed

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