hCathepsin L Citations (5)

Originally described in: SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H J Biol Chem. 2006 Feb 10;281(6):3198-203. doi: 10.1074/jbc.M508381200. Epub 2005 Dec 8. PubMed Journal

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Articles Citing hCathepsin L

Articles
Lysosomal ceramides regulate cathepsin B-mediated processing of saposin C and glucocerebrosidase activity. Kim MJ, Jeong H, Krainc D. Hum Mol Genet. 2022 Jul 21;31(14):2424-2437. doi: 10.1093/hmg/ddac047. PubMed
Impact of mutations defining SARS-CoV-2 Omicron subvariants BA.2.12.1 and BA.4/5 on Spike function and neutralization. Pastorio C, Noettger S, Nchioua R, Zech F, Sparrer KMJ, Kirchhoff F. iScience. 2023 Oct 27;26(11):108299. doi: 10.1016/j.isci.2023.108299. eCollection 2023 Nov 17. PubMed
Cathepsin L induces cellular senescence by upregulating CUX1 and p16(INK4a). Wu Y, Jiang D, Liu Q, Yan S, Liu X, Wu T, Sun W, Li G. Aging (Albany NY). 2024 Jun 18;16(13):10749-10764. doi: 10.18632/aging.205955. Epub 2024 Jun 18. PubMed
Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus. Xiang Q, Wouters C, Chang P, Lu YN, Liu M, Wang H, Yang J, Pekosz A, Zhang Y, Wang J. bioRxiv [Preprint]. 2024 Dec 5:2024.12.04.624804. doi: 10.1101/2024.12.04.624804. PubMed
Production of human cathepsins using Expi293 mammalian cell expression system for off-target activity of cysteine protease inhibitor screening. Turner Z, Arutyunova E, Bui DT, Han L, Kandadai AS, Bai B, Young HS, Mahal LK, Klassen JS, Lemieux MJ. Protein Sci. 2025 Nov;34(11):e70361. doi: 10.1002/pro.70361. PubMed

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