pXPR_053 Citations (3)
Originally described in: A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system.LaFleur MW, Nguyen TH, Coxe MA, Yates KB, Trombley JD, Weiss SA, Brown FD, Gillis JE, Coxe DJ, Doench JG, Haining WN, Sharpe AH Nat Commun. 2019 Apr 10;10(1):1668. doi: 10.1038/s41467-019-09656-2. PubMed Journal
Articles Citing pXPR_053
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| PTPN2 regulates the generation of exhausted CD8(+) T cell subpopulations and restrains tumor immunity. LaFleur MW, Nguyen TH, Coxe MA, Miller BC, Yates KB, Gillis JE, Sen DR, Gaudiano EF, Al Abosy R, Freeman GJ, Haining WN, Sharpe AH. Nat Immunol. 2019 Oct;20(10):1335-1347. doi: 10.1038/s41590-019-0480-4. Epub 2019 Sep 16. PubMed |
| Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8(+) T Cells. Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AH. Cancer Immunol Res. 2021 Feb;9(2):184-199. doi: 10.1158/2326-6066.CIR-20-0384. Epub 2020 Dec 4. PubMed |
X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system.
LaFleur MW, Lemmen AM, Streeter ISL, Nguyen TH, Milling LE, Derosia NM, Hoffman ZM, Gillis JE, Tjokrosurjo Q, Markson SC, Huang AY, Anekal PV, Montero Llopis P, Haining WN, Doench JG, Sharpe AH.
Nat Immunol. 2023 Nov 27. doi: 10.1038/s41590-023-01689-6.
PubMed
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