pLX209-neo-active WRN Citations (3)

Originally described in: WRN helicase is a synthetic lethal target in microsatellite unstable cancers.
Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ Nature. 2019 Apr 10. pii: 10.1038/s41586-019-1102-x. doi: 10.1038/s41586-019-1102-x. PubMed Journal

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Articles Citing pLX209-neo-active WRN

Articles
Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells. Leung AO, Yiu TC, Liu L, Tam HY, Gu S, Tu J, Pei D, Cheung HH. Cell Biosci. 2022 Dec 31;12(1):212. doi: 10.1186/s13578-022-00939-8. PubMed
Structural basis for a Poltheta helicase small-molecule inhibitor revealed by cryo-EM. Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT. Nat Commun. 2024 Aug 14;15(1):7003. doi: 10.1038/s41467-024-51351-4. PubMed
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells. Lazarchuk P, Nguyen MM, Curca CM, Pavlova MN, Oshima J, Sidorova JM. Aging (Albany NY). 2024 Oct 17;16(20):12977-13011. doi: 10.18632/aging.206132. Epub 2024 Oct 17. PubMed

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