pLVX-UbC-rtTA-Ngn2:2A:Ascl1 Citations (9)

Originally described in: Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons.
Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH Elife. 2019 May 17;8. pii: 41356. doi: 10.7554/eLife.41356. PubMed Journal

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Articles Citing pLVX-UbC-rtTA-Ngn2:2A:Ascl1

Articles
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Bohnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szucs A, Goldstein LSB, Galasko D, Gage FH. Cell Stem Cell. 2021 Sep 2;28(9):1533-1548.e6. doi: 10.1016/j.stem.2021.04.004. Epub 2021 Apr 27. PubMed
Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion. Bohnke L, Zhou-Yang L, Pelucchi S, Kogler F, Frantal D, Schon F, Lagerstrom S, Borgogno O, Baltazar J, Herdy JR, Kittel-Schneider S, Defrancesco M, Mertens J. Cell Reprogram. 2022 Oct;24(5):304-313. doi: 10.1089/cell.2021.0200. Epub 2022 Jul 25. PubMed
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szucs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. Cell Metab. 2022 Sep 6;34(9):1248-1263.e6. doi: 10.1016/j.cmet.2022.07.014. Epub 2022 Aug 19. PubMed
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. Cell Stem Cell. 2022 Dec 1;29(12):1637-1652.e6. doi: 10.1016/j.stem.2022.11.010. PubMed
The clinical utility and diagnostic implementation of human subject cell transdifferentiation followed by RNA sequencing. Li S, Zhao S, Sinson JC, Bajic A, Rosenfeld JA, Neeley MB, Pena M, Worley KC, Burrage LC, Weisz-Hubshman M, Ketkar S, Craigen WJ, Clark GD, Lalani S, Bacino CA, Machol K, Chao HT, Potocki L, Emrick L, Sheppard J, Nguyen MTT, Khoramnia A, Hernandez PP, Nagamani SC, Liu Z, Eng CM, Lee B, Liu P. Am J Hum Genet. 2024 May 2;111(5):841-862. doi: 10.1016/j.ajhg.2024.03.007. Epub 2024 Apr 8. PubMed
The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARgamma. Li X, Hernandez I, Koyuncu S, Kis B, Haggblad M, Lidemalm L, Abbas AA, Bendeguz S, Goblos A, Brautigam L, Lucas JJ, Carreras-Puigvert J, Huhn D, Pircs K, Vilchez D, Fernandez-Capetillo O. EBioMedicine. 2024 May;103:105124. doi: 10.1016/j.ebiom.2024.105124. Epub 2024 May 2. PubMed
RNA variant assessment using transactivation and transdifferentiation. Nicolas-Martinez EC, Robinson O, Pflueger C, Gardner A, Corbett MA, Ritchie T, Kroes T, van Eyk CL, Scheffer IE, Hildebrand MS, Barnier JV, Rousseau V, Genevieve D, Haushalter V, Piton A, Denomme-Pichon AS, Bruel AL, Nambot S, Isidor B, Grigg J, Gonzalez T, Ghedia S, Marchant RG, Bournazos A, Wong WK, Webster RI, Evesson FJ, Jones KJ, Cooper ST, Lister R, Gecz J, Jolly LA. Am J Hum Genet. 2024 Aug 8;111(8):1673-1699. doi: 10.1016/j.ajhg.2024.06.018. Epub 2024 Jul 30. PubMed
From Young to Old: Mimicking Neuronal Aging in Directly Converted Neurons from Young Donors. Varghese N, Grimm A, Cader MZ, Eckert A. Cells. 2024 Jul 26;13(15):1260. doi: 10.3390/cells13151260. PubMed
Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer's disease. Sun GG, Wang C, Mazzarino RC, Perez-Corredor PA, Davtyan H, Blurton-Jones M, Lopera F, Arboleda-Velasquez JF, Shi Y. Cell Rep. 2024 Dec 24;43(12):114982. doi: 10.1016/j.celrep.2024.114982. Epub 2024 Nov 28. PubMed

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