pLentiRNACRISPR_007 - TetO-NLS-RfxCas13d-NLS-WPRE-EFS-rtTA3-2A-Blast Citations (14)
Originally described in: Massively parallel Cas13 screens reveal principles for guide RNA design.Wessels HH, Mendez-Mancilla A, Guo X, Legut M, Daniloski Z, Sanjana NE Nat Biotechnol. 2020 Jun;38(6):722-727. doi: 10.1038/s41587-020-0456-9. Epub 2020 Mar 16. PubMed Journal
Articles Citing pLentiRNACRISPR_007 - TetO-NLS-RfxCas13d-NLS-WPRE-EFS-rtTA3-2A-Blast
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Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells.
Mendez-Mancilla A, Wessels HH, Legut M, Kadina A, Mabuchi M, Walker J, Robb GB, Holden K, Sanjana NE.
Cell Chem Biol. 2022 Feb 17;29(2):321-327.e4. doi: 10.1016/j.chembiol.2021.07.011. Epub 2021 Aug 2.
PubMed
Associated Plasmids |
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, Singh PK, Bi M, Shi CJ, Jamal N, Li G, Mistry R, Jung SY, Tsai KL, Ferreon JC, Stossi F, Caflisch A, Liu Z, Mancini MA, Li W.
Mol Cell. 2021 Aug 19;81(16):3368-3385.e9. doi: 10.1016/j.molcel.2021.07.024. Epub 2021 Aug 9.
PubMed
Associated Plasmids |
| Valine tRNA levels and availability regulate complex I assembly in leukaemia. Thandapani P, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Nature. 2022 Jan;601(7893):428-433. doi: 10.1038/s41586-021-04244-1. Epub 2021 Dec 22. PubMed |
| NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. Nat Immunol. 2022 Oct;23(10):1424-1432. doi: 10.1038/s41590-022-01314-y. Epub 2022 Sep 22. PubMed |
| CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression. Noviello G, Gjaltema RAF, Schulz EG. Nat Commun. 2023 Jun 3;14(1):3225. doi: 10.1038/s41467-023-38909-4. PubMed |
| METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma. Vaid R, Thombare K, Mendez A, Burgos-Panadero R, Djos A, Jachimowicz D, Lundberg KI, Bartenhagen C, Kumar N, Tummler C, Sihlbom C, Fransson S, Johnsen JI, Kogner P, Martinsson T, Fischer M, Mondal T. Nucleic Acids Res. 2024 Jan 5:gkad1242. doi: 10.1093/nar/gkad1242. PubMed |
| METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma. Thombare K, Vaid R, Pucci P, Ihrmark Lundberg K, Ayyalusamy R, Baig MH, Mendez A, Burgos-Panadero R, Hoppner S, Bartenhagen C, Sjovall D, Rehan AA, Dattatraya Nale S, Djos A, Martinsson T, Jaako P, Dong JJ, Kogner P, Johnsen JI, Fischer M, Turner SD, Mondal T. EMBO J. 2024 Dec;43(24):6310-6335. doi: 10.1038/s44318-024-00299-8. Epub 2024 Nov 11. PubMed |
Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells.
Liang WW, Muller S, Hart SK, Wessels HH, Mendez-Mancilla A, Sookdeo A, Choi O, Caragine CM, Corman A, Lu L, Kolumba O, Williams B, Sanjana NE.
Cell. 2024 Dec 26;187(26):7637-7654.e29. doi: 10.1016/j.cell.2024.10.021. Epub 2024 Nov 11.
PubMed
Associated Plasmids |
Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision.
Shembrey C, Yang R, Casan J, Hu W, Chen H, Singh GJ, Sadras T, Prasad K, Shortt J, Johnstone RW, Trapani JA, Ekert PG, Fareh M.
Sci Adv. 2024 Dec 20;10(51):eadl0731. doi: 10.1126/sciadv.adl0731. Epub 2024 Dec 18.
PubMed
Associated Plasmids |
| Pathogenetic mechanisms of muscle-specific ribosomes in dilated cardiomyopathy. Murphy MR, Ganapathi M, Lee TM, Fisher JM, Patel MV, Jayakar P, Buchanan A, Rippert AL, Ahrens-Nicklas RC, Nair D, Soni RK, Yin Y, Yang F, Reilly MP, Chung WK, Wu X. bioRxiv [Preprint]. 2025 Jan 28:2025.01.02.630345. doi: 10.1101/2025.01.02.630345. PubMed |
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers.
Caragine CM, Le VT, Mustafa M, Diaz BJ, Morris JA, Muller S, Mendez-Mancilla A, Geller E, Liscovitch-Brauer N, Sanjana NE.
Nat Commun. 2025 Feb 13;16(1):1611. doi: 10.1038/s41467-025-56568-5.
PubMed
Associated Plasmids |
| Impact of circPVT1 Expression on Prostate Cancer Malignancy and Tumor Growth. Umemori M, Tashiro K, Horiguchi A, Urabe F, Kimura T, Sato S, Hiroyuki T, Kurata M. Acta Histochem Cytochem. 2025 Jun 24;58(3):133-141. doi: 10.1267/ahc.25-00008. Epub 2025 Jun 18. PubMed |
| An Isoform-Specific RUNX1C-BTG2 Axis Governs AML Quiescence and Chemoresistance. Han C, Zhang Z, Crosse EI, Sajedi S, Lu B, Wang X, Karma S, Kostich M, Rajendran SH, Udy DB, Chen S, Arnuk A, Lawal AE, Koenig KR, McKenna M, Reville PK, Abbas HA, Abdel-Wahab O, Miura P, Bradley RK, Wang E. Blood Cancer Discov. 2025 Sep 3;6(5):464-483. doi: 10.1158/2643-3230.BCD-24-0327. PubMed |
| Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox. Schertzer MD, Stirn A, Isaev K, Pereira L, Park SH, Das A, Real A, Jeffery ED, Harbison C, Wessels HH, Sheynkman GM, Sanjana NE, Knowles DA. Nat Commun. 2025 Jul 29;16(1):6948. doi: 10.1038/s41467-025-62066-5. PubMed |
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