NG-ABE8e Citations (21)
Originally described in: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity.Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR Nat Biotechnol. 2020 Jul;38(7):883-891. doi: 10.1038/s41587-020-0453-z. Epub 2020 Mar 16. PubMed Journal
Articles Citing NG-ABE8e
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| Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease. Kim Y, Hong SA, Yu J, Eom J, Jang K, Yoon S, Hong DH, Seo D, Lee SN, Woo JS, Jeong J, Bae S, Choi D. Cell Stem Cell. 2021 Sep 2;28(9):1614-1624.e5. doi: 10.1016/j.stem.2021.04.010. Epub 2021 May 4. PubMed |
| RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations. Sidorova OA, Sayed S, Paszkowski-Rogacz M, Seifert M, Camgoz A, Roeder I, Bornhauser M, Thiede C, Buchholz F. Cells. 2022 Mar 2;11(5). pii: cells11050854. doi: 10.3390/cells11050854. PubMed |
| Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing. Sayed S, Sidorova OA, Hennig A, Augsburg M, Cortes Vesga CP, Abohawya M, Schmitt LT, Surun D, Stange DE, Mircetic J, Buchholz F. Cancer Res. 2022 Sep 2;82(17):3002-3015. doi: 10.1158/0008-5472.CAN-21-2519. PubMed |
| A precise and efficient adenine base editor. Tu T, Song Z, Liu X, Wang S, He X, Xi H, Wang J, Yan T, Chen H, Zhang Z, Lv X, Lv J, Huang XF, Zhao J, Lin CP, Gao C, Zhang J, Gu F. Mol Ther. 2022 Sep 7;30(9):2933-2941. doi: 10.1016/j.ymthe.2022.07.010. Epub 2022 Jul 12. PubMed |
| Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy. Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN. Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633. Epub 2022 Nov 23. PubMed |
| In vivo adenine base editing corrects newborn murine model of Hurler syndrome. Su J, Jin X, She K, Liu Y, Song L, Zhao Q, Xiao J, Li R, Deng H, Lu F, Yang Y. Mol Biomed. 2023 Feb 23;4(1):6. doi: 10.1186/s43556-023-00120-8. PubMed |
| Human T cell generation is restored in CD3delta severe combined immunodeficiency through adenine base editing. McAuley GE, Yiu G, Chang PC, Newby GA, Campo-Fernandez B, Fitz-Gibbon ST, Wu X, Kang SL, Garibay A, Butler J, Christian V, Wong RL, Everette KA, Azzun A, Gelfer H, Seet CS, Narendran A, Murguia-Favela L, Romero Z, Wright N, Liu DR, Crooks GM, Kohn DB. Cell. 2023 Mar 30;186(7):1398-1416.e23. doi: 10.1016/j.cell.2023.02.027. Epub 2023 Mar 20. PubMed |
| Highly Efficient A-to-G Editing in PFFs via Multiple ABEs. Jing Q, Liu W, Jiang H, Liao Y, Yang Q, Xing Y. Genes (Basel). 2023 Apr 13;14(4):908. doi: 10.3390/genes14040908. PubMed |
| Single-swap editing for the correction of common Duchenne muscular dystrophy mutations. Chai AC, Chemello F, Li H, Nishiyama T, Chen K, Zhang Y, Sanchez-Ortiz E, Alomar A, Xu L, Liu N, Bassel-Duby R, Olson EN. Mol Ther Nucleic Acids. 2023 Apr 19;32:522-535. doi: 10.1016/j.omtn.2023.04.009. eCollection 2023 Jun 13. PubMed |
| Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3' untranslated region mutations. Schuster SL, Arora S, Wladyka CL, Itagi P, Corey L, Young D, Stackhouse BL, Kollath L, Wu QV, Corey E, True LD, Ha G, Paddison PJ, Hsieh AC. Cell Rep. 2023 Aug 29;42(8):112840. doi: 10.1016/j.celrep.2023.112840. Epub 2023 Jul 28. PubMed |
| PAX3-FOXO1 uses its activation domain to recruit CBP/P300 and shape RNA Pol2 cluster distribution. Asante Y, Benischke K, Osman I, Ngo QA, Wurth J, Laubscher D, Kim H, Udhayakumar B, Khan MIH, Chin DH, Porch J, Chakraborty M, Sallari R, Delattre O, Zaidi S, Morice S, Surdez D, Danielli SG, Schafer BW, Gryder BE, Wachtel M. Nat Commun. 2023 Dec 15;14(1):8361. doi: 10.1038/s41467-023-43780-4. PubMed |
| Development and testing of a versatile genome editing application reporter (V-GEAR) system. Kleinboehl EW, Laoharawee K, Lahr WS, Jensen JD, Peterson JJ, Bell JB, Webber BR, Moriarity BS. Mol Ther Methods Clin Dev. 2024 Apr 24;32(2):101253. doi: 10.1016/j.omtm.2024.101253. eCollection 2024 Jun 13. PubMed |
| Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection. Liu Y, Yang L, Xiang HY, Niu M, Deng JC, Li XY, Hao WJ, Ou-Yang HS, Liu TY, Tang XC, Pang DX, Yuan HM. Zool Res. 2024 Jul 18;45(4):833-844. doi: 10.24272/j.issn.2095-8137.2024.090. PubMed |
Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis.
Fernandez M, Yu L, Jia Q, Wang X, Hart KL, Jia Z, Lin RJ, Wang L.
Cancer Res Commun. 2024 Aug 28. doi: 10.1158/2767-9764.CRC-24-0145.
PubMed
Associated Plasmids |
| Systematic identification of pathogenic variants of non-small cell lung cancer in the promoters of DNA-damage repair genes. An M, Chen C, Xiang J, Li Y, Qiu P, Tang Y, Liu X, Gu Y, Qin N, He Y, Zhu M, Jiang Y, Dai J, Jin G, Ma H, Wang C, Hu Z, Shen H. EBioMedicine. 2024 Dec;110:105480. doi: 10.1016/j.ebiom.2024.105480. Epub 2024 Dec 3. PubMed |
| Systematic empirical evaluation of individual base editing targets: Validating therapeutic targets in USH2A and comparison of methods. Tachida Y, Manian KV, Butcher R, Levy JM, Pendse N, Hennessey E, Liu DR, Pierce EA, Liu Q, Comander J. Mol Ther. 2025 Apr 2;33(4):1466-1484. doi: 10.1016/j.ymthe.2025.01.042. Epub 2025 Jan 28. PubMed |
| Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer. Chen C, Li Y, Gu Y, Zhai Q, Guo S, Xiang J, Xie Y, An M, Li C, Qin N, Shi Y, Yang L, Zhou J, Xu X, Xu Z, Wang K, Zhu M, Jiang Y, He Y, Xu J, Yin R, Chen L, Xu L, Dai J, Jin G, Hu Z, Wang C, Ma H, Shen H. Nat Commun. 2025 Feb 6;16(1):1391. doi: 10.1038/s41467-025-56725-w. PubMed |
| PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation. Hu SW, Jeong S, Jiang L, Koo H, Wang Z, Choi WH, Zhu B, Seok H, Zhou Y, Kim MG, Mu D, Guo H, Zhou Z, Jung SH, Zhang Y, Chae HB, Chen L, Lee SY, Guo L, Suh MW, Xiao Y, Park MK, Tang H, Song JJ, Chen X, Chen A, Lee JH, Bae S, Lee SY, Shu Y. Nat Commun. 2025 Aug 5;16(1):7186. doi: 10.1038/s41467-025-62562-8. PubMed |
A streamlined base editor engineering strategy to reduce bystander editing.
Valdez I, O'Connor I, Patel D, Gierer K, Harrington J, Ellis E, Caponetti SA, Sebra RP, Valley HC, Coote K, Mense M, Marro SG, Jiang T.
Nat Commun. 2025 Aug 30;16(1):8115. doi: 10.1038/s41467-025-63609-6.
PubMed
Associated Plasmids |
| A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy. Croce KR, Ng C, Pankiv S, Albarran E, Langfelder P, Ramos de Jesus A, Duncan GM, Wang N, Basile A, McHugh C, Litt NA, Li A, Friedman S, Cortes EP, Zody MC, Yang XW, Ding JB, Vonsattel JPG, Simonsen A, Housman DE, Wexler NS, Yamamoto A. Neuron. 2025 Nov 19;113(22):3780-3797.e7. doi: 10.1016/j.neuron.2025.08.018. Epub 2025 Sep 12. PubMed |
| Correction: Adenine base editing of CFTR using receptor targeted nanoparticles restores function to G542X cystic fibrosis airway epithelial cells. Rose I, Greenwood M, Biggart M, Baumlin N, Tarran R, Hart SL, Baines DL. Cell Mol Life Sci. 2025 Sep 27;82(1):341. doi: 10.1007/s00018-025-05907-2. PubMed |
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