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pRK5-HA GST RagA 66L Citations (10)

Originally described in: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM Science. 2008 Jun 13. 320(5882):1496-501. PubMed Journal

Articles Citing pRK5-HA GST RagA 66L

Articles
Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Hong-Brown LQ, Brown CR, Kazi AA, Navaratnarajah M, Lang CH. Am J Physiol Cell Physiol. 2012 May 15;302(10):C1557-65. doi: 10.1152/ajpcell.00407.2011. Epub 2012 Mar 21. PubMed
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes. Martina JA, Puertollano R. J Cell Biol. 2013 Feb 18;200(4):475-91. doi: 10.1083/jcb.201209135. Epub 2013 Feb 11. PubMed
Preliminary functional assessment and classification of DEPDC5 variants associated with focal epilepsy. van Kranenburg M, Hoogeveen-Westerveld M, Nellist M. Hum Mutat. 2015 Feb;36(2):200-9. doi: 10.1002/humu.22723. Epub 2014 Nov 27. PubMed
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Rebsamen M, Pochini L, Stasyk T, de Araujo ME, Galluccio M, Kandasamy RK, Snijder B, Fauster A, Rudashevskaya EL, Bruckner M, Scorzoni S, Filipek PA, Huber KV, Bigenzahn JW, Heinz LX, Kraft C, Bennett KL, Indiveri C, Huber LA, Superti-Furga G. Nature. 2015 Mar 26;519(7544):477-81. doi: 10.1038/nature14107. Epub 2015 Jan 7. PubMed
Regulation of mTORC1 by lysosomal calcium and calmodulin. Li RJ, Xu J, Fu C, Zhang J, Zheng YG, Jia H, Liu JO. Elife. 2016 Oct 27;5. pii: e19360. doi: 10.7554/eLife.19360. PubMed
Galectins Control mTOR in Response to Endomembrane Damage. Jia J, Abudu YP, Claude-Taupin A, Gu Y, Kumar S, Choi SW, Peters R, Mudd MH, Allers L, Salemi M, Phinney B, Johansen T, Deretic V. Mol Cell. 2018 Apr 5;70(1):120-135.e8. doi: 10.1016/j.molcel.2018.03.009. PubMed

Associated Plasmids
Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson JR, Rodney GG, Sardiello M. Nat Commun. 2018 Oct 19;9(1):4351. doi: 10.1038/s41467-018-06844-4. PubMed
The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, Seki A, Shen K, Iyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer T. Nat Cell Biol. 2019 May;21(5):614-626. doi: 10.1038/s41556-019-0321-6. Epub 2019 Apr 29. PubMed
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex. Hirst J, Hesketh GG, Gingras AC, Robinson MS. J Cell Biol. 2021 Feb 1;220(2). pii: 211690. doi: 10.1083/jcb.202002075. PubMed
TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Alesi N, Akl EW, Khabibullin D, Liu HJ, Nidhiry AS, Garner ER, Filippakis H, Lam HC, Shi W, Viswanathan SR, Morroni M, Ferguson SM, Henske EP. Nat Commun. 2021 Jul 12;12(1):4245. doi: 10.1038/s41467-021-24499-6. PubMed

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