pBABE-puro mCherry-EGFP-LC3B Citations (187)

Originally described in: PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.
N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, Brown EJ EMBO Rep. 2009 Feb;10(2):173-9. doi: 10.1038/embor.2008.238. Epub 2009 Jan 16. PubMed Journal

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Articles Citing pBABE-puro mCherry-EGFP-LC3B

Articles
IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL. PLoS Pathog. 2011 Oct;7(10):e1002337. doi: 10.1371/journal.ppat.1002337. Epub 2011 Oct 27. PubMed
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Cell. 2012 May 11;149(4):780-94. doi: 10.1016/j.cell.2012.03.031. PubMed
Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage. Han J, Pan XY, Xu Y, Xiao Y, An Y, Tie L, Pan Y, Li XJ. Autophagy. 2012 May 1;8(5):812-25. doi: 10.4161/auto.19471. Epub 2012 May 1. PubMed
Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. Stankov MV, Panayotova-Dimitrova D, Leverkus M, Vondran FW, Bauerfeind R, Binz A, Behrens GM. AIDS. 2012 Oct 23;26(16):1995-2006. doi: 10.1097/QAD.0b013e32835804f9. PubMed
Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Stankov MV, Panayotova-Dimitrova D, Leverkus M, Schmidt RE, Behrens GM. Antimicrob Agents Chemother. 2013 Jan;57(1):543-51. doi: 10.1128/AAC.01560-12. Epub 2012 Nov 12. PubMed
Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. Wang N, Zimmerman K, Raab RW, McKown RL, Hutnik CM, Talla V, Tyler MF 4th, Lee JK, Laurie GW. J Biol Chem. 2013 Jun 21;288(25):18146-61. doi: 10.1074/jbc.M112.436584. Epub 2013 May 2. PubMed Associated Plasmids pTYB1-pLAC-N45 pTYB1-pLAC-N71 pTYB1-pLAC-V69S pTYB1-pLAC-I73S pTYB1-pLAC-I98S More ...
Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models. Adiseshaiah PP, Clogston JD, McLeland CB, Rodriguez J, Potter TM, Neun BW, Skoczen SL, Shanmugavelandy SS, Kester M, Stern ST, McNeil SE. Cancer Lett. 2013 Sep 1;337(2):254-65. doi: 10.1016/j.canlet.2013.04.034. Epub 2013 May 7. PubMed
Knockdown of core binding factorbeta alters sphingolipid metabolism. Greer AH, Yong T, Fennell K, Moustafa YW, Fowler M, Galiano F, Ng SW, Berkowitz RS, Cardelli J, Meyers S, Davis JN. J Cell Physiol. 2013 Dec;228(12):2350-64. doi: 10.1002/jcp.24406. PubMed
Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. Slattum G, Gu Y, Sabbadini R, Rosenblatt J. Curr Biol. 2014 Jan 6;24(1):19-28. doi: 10.1016/j.cub.2013.11.029. Epub 2013 Dec 19. PubMed
Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation. B'chir W, Chaveroux C, Carraro V, Averous J, Maurin AC, Jousse C, Muranishi Y, Parry L, Fafournoux P, Bruhat A. Cell Signal. 2014 Jul;26(7):1385-91. doi: 10.1016/j.cellsig.2014.03.009. Epub 2014 Mar 18. PubMed
Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport. Kuzu OF, Gowda R, Sharma A, Robertson GP. Mol Cancer Ther. 2014 Jul;13(7):1690-703. doi: 10.1158/1535-7163.MCT-13-0868. Epub 2014 Mar 31. PubMed
Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression. Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H. Cell Rep. 2014 May 22;7(4):1143-55. doi: 10.1016/j.celrep.2014.03.061. Epub 2014 May 1. PubMed
Inhibition of autophagic flux by salinomycin results in anti-cancer effect in hepatocellular carcinoma cells. Klose J, Stankov MV, Kleine M, Ramackers W, Panayotova-Dimitrova D, Jager MD, Klempnauer J, Winkler M, Bektas H, Behrens GM, Vondran FW. PLoS One. 2014 May 9;9(5):e95970. doi: 10.1371/journal.pone.0095970. eCollection 2014. PubMed
A nonapoptotic role for CASP2/caspase 2: modulation of autophagy. Tiwari M, Sharma LK, Vanegas D, Callaway DA, Bai Y, Lechleiter JD, Herman B. Autophagy. 2014 Jun;10(6):1054-70. doi: 10.4161/auto.28528. PubMed
Sorting cells for basal and induced autophagic flux by quantitative ratiometric flow cytometry. Gump JM, Thorburn A. Autophagy. 2014 Jul;10(7):1327-34. doi: 10.4161/auto.29394. Epub 2014 Jun 5. PubMed
Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik. Chen S, Zhou L, Zhang Y, Leng Y, Pei XY, Lin H, Jones R, Orlowski RZ, Dai Y, Grant S. Mol Cell Biol. 2014 Sep 15;34(18):3435-49. doi: 10.1128/MCB.01383-13. Epub 2014 Jul 7. PubMed
Formation of alpha-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. Volpicelli-Daley LA, Gamble KL, Schultheiss CE, Riddle DM, West AB, Lee VM. Mol Biol Cell. 2014 Dec 15;25(25):4010-23. doi: 10.1091/mbc.E14-02-0741. Epub 2014 Oct 8. PubMed
Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Am J Physiol Cell Physiol. 2015 Feb 1;308(3):C249-63. doi: 10.1152/ajpcell.00265.2014. Epub 2014 Oct 29. PubMed
Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons. Lee H, Lee JK, Park MH, Hong YR, Marti HH, Kim H, Okada Y, Otsu M, Seo EJ, Park JH, Bae JH, Okino N, He X, Schuchman EH, Bae JS, Jin HK. Nat Commun. 2014 Nov 24;5:5514. doi: 10.1038/ncomms6514. PubMed
GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. Bhattacharya S, Pal K, Sharma AK, Dutta SK, Lau JS, Yan IK, Wang E, Elkhanany A, Alkharfy KM, Sanyal A, Patel TC, Chari ST, Spaller MR, Mukhopadhyay D. PLoS One. 2014 Dec 3;9(12):e114409. doi: 10.1371/journal.pone.0114409. eCollection 2014. PubMed
Measuring autophagy in stressed cells. Sharifi MN, Mowers EE, Drake LE, Macleod KF. Methods Mol Biol. 2015;1292:129-50. doi: 10.1007/978-1-4939-2522-3_10. PubMed
Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis. Sundaramoorthy V, Walker AK, Tan V, Fifita JA, Mccann EP, Williams KL, Blair IP, Guillemin GJ, Farg MA, Atkin JD. Hum Mol Genet. 2015 Jul 1;24(13):3830-46. doi: 10.1093/hmg/ddv126. Epub 2015 Apr 9. PubMed
Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease. Erie C, Sacino M, Houle L, Lu ML, Wei J. Eur J Neurosci. 2015 May 22. doi: 10.1111/ejn.12957. PubMed
Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Sun T, Li X, Zhang P, Chen WD, Zhang HL, Li DD, Deng R, Qian XJ, Jiao L, Ji J, Li YT, Wu RY, Yu Y, Feng GK, Zhu XF. Nat Commun. 2015 May 26;6:7215. doi: 10.1038/ncomms8215. PubMed
Regulation of autophagic flux by CHIP. Guo D, Ying Z, Wang H, Chen D, Gao F, Ren H, Wang G. Neurosci Bull. 2015 Aug;31(4):469-79. doi: 10.1007/s12264-015-1543-7. Epub 2015 Jul 28. PubMed
Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo. O'Donovan TR, Rajendran S, O'Reilly S, O'Sullivan GC, McKenna SL. PLoS One. 2015 Aug 6;10(8):e0134676. doi: 10.1371/journal.pone.0134676. eCollection 2015. PubMed
HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons. Guedes-Dias P, de Proenca J, Soares TR, Leitao-Rocha A, Pinho BR, Duchen MR, Oliveira JM. Biochim Biophys Acta. 2015 Nov;1852(11):2484-93. doi: 10.1016/j.bbadis.2015.08.012. Epub 2015 Aug 21. PubMed
Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Elife. 2015 Sep 1;4:e08153. doi: 10.7554/eLife.08153. PubMed
A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer. Delaney JR, Patel C, McCabe KE, Lu D, Davis MA, Tancioni I, von Schalscha T, Bartakova A, Haft C, Schlaepfer DD, Stupack DG. Oncotarget. 2015 Oct 13;6(31):31104-18. doi: 10.18632/oncotarget.5093. PubMed
MDM2 Inhibitor, Nutlin 3a, Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation. Borthakur G, Duvvuri S, Ruvolo V, Tripathi DN, Piya S, Burks J, Jacamo R, Kojima K, Ruvolo P, Fueyo-Margareto J, Konopleva M, Andreeff M. PLoS One. 2015 Oct 6;10(10):e0139254. doi: 10.1371/journal.pone.0139254. eCollection 2015. PubMed
A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. Circu ML, Dykes SS, Carroll J, Kelly K, Galiano F, Greer A, Cardelli J, El-Osta H. PLoS One. 2016 Jan 19;11(1):e0146931. doi: 10.1371/journal.pone.0146931. eCollection 2016. PubMed
Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload. Fu L, Wei CC, Powell PC, Bradley WE, Ahmad S, Ferrario CM, Collawn JF, Dell'Italia LJ. J Mol Cell Cardiol. 2016 Jan 22;92:1-9. doi: 10.1016/j.yjmcc.2016.01.019. PubMed
Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus. Xi Y, Dhaliwal JS, Ceizar M, Vaculik M, Kumar KL, Lagace DC. Cell Death Dis. 2016 Mar 3;7:e2127. doi: 10.1038/cddis.2015.406. PubMed
BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux. Reljic B, Conos S, Lee EF, Garnier JM, Dong L, Lessene G, Fairlie WD, Vaux DL, Lindqvist LM. Autophagy. 2016 Jul 2;12(7):1083-93. doi: 10.1080/15548627.2016.1179406. Epub 2016 May 12. PubMed
ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds. Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinivasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H. Am J Cancer Res. 2016 Mar 15;6(4):781-96. eCollection 2016. PubMed
Genetic Ablation of Calcium-independent Phospholipase A2gamma Induces Glomerular Injury in Mice. Elimam H, Papillon J, Kaufman DR, Guillemette J, Aoudjit L, Gross RW, Takano T, Cybulsky AV. J Biol Chem. 2016 Jul 8;291(28):14468-82. doi: 10.1074/jbc.M115.696781. Epub 2016 May 12. PubMed
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling. Choi H, Merceron C, Mangiavini L, Seifert EL, Schipani E, Shapiro IM, Risbud MV. Autophagy. 2016 Sep;12(9):1631-46. doi: 10.1080/15548627.2016.1192753. Epub 2016 Jun 17. PubMed
TBC1D20 mediates autophagy as a key regulator of autophagosome maturation. Sidjanin DJ, Park AK, Ronchetti A, Martins J, Jackson WT. Autophagy. 2016 Oct 2;12(10):1759-1775. Epub 2016 Aug 3. PubMed
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Nature. 2016 Aug 25;536(7617):479-83. PubMed
Knockdown of GSK3beta increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Weikel KA, Cacicedo JM, Ruderman NB, Ido Y. Biosci Rep. 2016 Sep 16;36(5). pii: e00382. doi: 10.1042/BSR20160174. Print 2016 Oct. PubMed
SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes. Choi YK, Cho SG, Choi YJ, Yun YJ, Lee KM, Lee K, Yoo HH, Shin YC, Ko SG. Oncotarget. 2016 Aug 19. doi: 10.18632/oncotarget.11393. PubMed
Enhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension. Dalvi P, Sharma H, Chinnappan M, Sanderson M, Allen J, Zeng R, Choi A, O'Brien-Ladner A, Dhillon NK. Autophagy. 2016 Dec;12(12):2420-2438. Epub 2016 Oct 10. PubMed
Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Huang M, Garcia JS, Thomas D, Zhu L, Nguyen LX, Chan SM, Majeti R, Medeiros BC, Mitchell BS. Oncotarget. 2016 Nov 15;7(46):74917-74930. doi: 10.18632/oncotarget.12493. PubMed
MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. Kim JK, Lee HM, Park KS, Shin DM, Kim TS, Kim YS, Suh HW, Kim SY, Kim IS, Kim JM, Son JW, Sohn KM, Jung SS, Chung C, Han SB, Yang CS, Jo EK. Autophagy. 2016 Oct 20:1-19. doi: 10.1080/15548627.2016.1241922. PubMed
Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Han J, Bae J, Choi CY, Choi SP, Kang HS, Jo EK, Park J, Lee YS, Moon HS, Park CG, Lee MS, Chun T. Autophagy. 2016 Dec;12(12):2326-2343. PubMed
HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Watanabe Y, Tsujimura A, Taguchi K, Tanaka M. Autophagy. 2017 Jan 2;13(1):133-148. doi: 10.1080/15548627.2016.1248018. Epub 2016 Nov 15. PubMed
FSH protects mouse granulosa cells from oxidative damage by repressing mitophagy. Shen M, Jiang Y, Guan Z, Cao Y, Sun SC, Liu H. Sci Rep. 2016 Nov 30;6:38090. doi: 10.1038/srep38090. PubMed
Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling. Henry WS, Laszewski T, Tsang T, Beca F, Beck AH, McAllister SS, Toker A. Cancer Res. 2016 Dec 9. pii: canres.2400.2016. PubMed
Caspase-2-mediated cell death is required for deleting aneuploid cells. Dawar S, Lim Y, Puccini J, White M, Thomas P, Bouchier-Hayes L, Green DR, Dorstyn L, Kumar S. Oncogene. 2016 Dec 19. doi: 10.1038/onc.2016.423. PubMed
Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress. Baek A, Yoon S, Kim J, Baek YM, Park H, Lim D, Chung H, Kim DE. Autophagy. 2017 Jan 3:0. doi: 10.1080/15548627.2016.1256932. PubMed
p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration. Jackson KL, Lin WL, Miriyala S, Dayton RD, Panchatcharam M, McCarthy KJ, Castanedes-Casey M, Dickson DW, Klein RL. PLoS One. 2017 Jan 11;12(1):e0169291. doi: 10.1371/journal.pone.0169291. eCollection 2017. PubMed
Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Li Y, Li G, Wang K, Xie YY, Zhou RP, Meng Y, Ding R, Ge JF, Chen FH. Toxicol Appl Pharmacol. 2017 Mar 15;319:1-11. doi: 10.1016/j.taap.2017.01.016. Epub 2017 Jan 25. PubMed
Tenovin-6 impairs autophagy by inhibiting autophagic flux. Yuan H, Tan B, Gao SJ. Cell Death Dis. 2017 Feb 9;8(2):e2608. doi: 10.1038/cddis.2017.25. PubMed
Elatoside C protects against ox-LDL-induced HUVECs injury by FoxO1-mediated autophagy induction. Luo Y, Meng X, Zhou P, Lu S, Qin M, Xu X, Sun G, Sun X. Biochim Biophys Acta. 2017 Jun;1863(6):1654-1665. doi: 10.1016/j.bbadis.2017.01.017. Epub 2017 Feb 9. PubMed
Glucagon-Like Peptide 1 Protects Pancreatic beta-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function. Zummo FP, Cullen KS, Honkanen-Scott M, Shaw JAM, Lovat PE, Arden C. Diabetes. 2017 May;66(5):1272-1285. doi: 10.2337/db16-1009. Epub 2017 Feb 23. PubMed
Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Tavera-Mendoza LE, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, Cameron LA, Ficarro SB, Marto JA, Klawitter J, Brown M. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2186-E2194. doi: 10.1073/pnas.1615015114. Epub 2017 Feb 27. PubMed
PPAR-alpha Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism. Kim YS, Lee HM, Kim JK, Yang CS, Kim TS, Jung M, Jin HS, Kim S, Jang J, Oh GT, Kim JM, Jo EK. J Immunol. 2017 Apr 15;198(8):3283-3295. doi: 10.4049/jimmunol.1601920. Epub 2017 Mar 8. PubMed
Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. Son YO, Pratheeshkumar P, Divya SP, Zhang Z, Shi X. J Biol Chem. 2017 May 19;292(20):8315-8330. doi: 10.1074/jbc.M116.773986. Epub 2017 Mar 22. PubMed
NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. Rah SY, Lee YH, Kim UH. FASEB J. 2017 Jul;31(7):3126-3137. doi: 10.1096/fj.201601290R. Epub 2017 Apr 6. PubMed
Deletion of inositol-requiring enzyme-1alpha in podocytes disrupts glomerular capillary integrity and autophagy. Kaufman DR, Papillon J, Larose L, Iwawaki T, Cybulsky AV. Mol Biol Cell. 2017 Jun 15;28(12):1636-1651. doi: 10.1091/mbc.E16-12-0828. Epub 2017 Apr 20. PubMed
TIR-domain-containing adapter-inducing interferon-beta (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Hacker G. FEBS J. 2017 Jul;284(13):1987-2003. doi: 10.1111/febs.14091. Epub 2017 May 19. PubMed
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis. Casimiro MC, Di Sante G, Di Rocco A, Loro E, Pupo C, Pestell TG, Bisetto S, Velasco-Velazquez MA, Jiao X, Li Z, Kusminski CM, Seifert EL, Wang C, Ly D, Zheng B, Shen CH, Scherer PE, Pestell RG. Cancer Res. 2017 Jul 1;77(13):3391-3405. doi: 10.1158/0008-5472.CAN-16-0425. Epub 2017 May 18. PubMed
Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy. Ding L, Wang Q, Shen M, Sun Y, Zhang X, Huang C, Chen J, Li R, Duan Y. Autophagy. 2017 Jul 3;13(7):1176-1190. doi: 10.1080/15548627.2017.1320634. Epub 2017 Jun 8. PubMed
Effects of Epigallocatechin-3-Gallate on Autophagic Lipolysis in Adipocytes. Kim SN, Kwon HJ, Akindehin S, Jeong HW, Lee YH. Nutrients. 2017 Jun 30;9(7). pii: E680. doi: 10.3390/nu9070680. PubMed
Modulating cancer cell survival by targeting intracellular cholesterol transport. Kuzu OF, Gowda R, Noory MA, Robertson GP. Br J Cancer. 2017 Aug 8;117(4):513-524. doi: 10.1038/bjc.2017.200. Epub 2017 Jul 11. PubMed
Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis. Wang N, Tan HY, Li S, Feng Y. Theranostics. 2017 Jun 2;7(8):2325-2338. doi: 10.7150/thno.18225. eCollection 2017. PubMed
Connexin 43 is required for the maintenance of mitochondrial integrity in brown adipose tissue. Kim SN, Kwon HJ, Im SW, Son YH, Akindehin S, Jung YS, Lee SJ, Rhyu IJ, Kim IY, Seong JK, Lee J, Yoo HC, Granneman JG, Lee YH. Sci Rep. 2017 Aug 2;7(1):7159. doi: 10.1038/s41598-017-07658-y. PubMed
AMBRA1 is involved in T cell receptor-mediated metabolic reprogramming through an ATG7-independent pathway. Akatsuka H, Kuga S, Masuhara K, Davaadorj O, Okada C, Iida Y, Okada Y, Fukunishi N, Suzuki T, Hosomichi K, Ohtsuka M, Tanaka M, Inoue I, Kimura M, Sato T. Biochem Biophys Res Commun. 2017 Sep 30;491(4):1098-1104. doi: 10.1016/j.bbrc.2017.08.019. Epub 2017 Aug 5. PubMed
Three-dimensional tumor cell growth stimulates autophagic flux and recapitulates chemotherapy resistance. Bingel C, Koeneke E, Ridinger J, Bittmann A, Sill M, Peterziel H, Wrobel JK, Rettig I, Milde T, Fernekorn U, Weise F, Schober A, Witt O, Oehme I. Cell Death Dis. 2017 Aug 24;8(8):e3013. doi: 10.1038/cddis.2017.398. PubMed
ESRRA (estrogen-related receptor alpha) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Kim SY, Yang CS, Lee HM, Kim JK, Kim YS, Kim YR, Kim JS, Kim TS, Yuk JM, Dufour CR, Lee SH, Kim JM, Choi HS, Giguere V, Jo EK. Autophagy. 2018;14(1):152-168. doi: 10.1080/15548627.2017.1339001. Epub 2017 Sep 1. PubMed
REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival. Choi J, Kim H, Bae YK, Cheong H. Int J Mol Sci. 2017 Aug 28;18(9). pii: ijms18091866. doi: 10.3390/ijms18091866. PubMed
Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Lee A, Rayner SL, Gwee SSL, De Luca A, Shahheydari H, Sundaramoorthy V, Ragagnin A, Morsch M, Radford R, Galper J, Freckleton S, Shi B, Walker AK, Don EK, Cole NJ, Yang S, Williams KL, Yerbury JJ, Blair IP, Atkin JD, Molloy MP, Chung RS. Cell Mol Life Sci. 2018 Jan;75(2):335-354. doi: 10.1007/s00018-017-2632-8. Epub 2017 Aug 29. PubMed
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy. Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, Lin B, Wang G, Wang Z, Sun W, Sun M, Chang S, Cai Z, Hua Y. Cell Death Dis. 2017 Sep 14;8(9):e3048. doi: 10.1038/cddis.2017.438. PubMed
Peptides derived from evolutionarily conserved domains in Beclin-1 and Beclin-2 enhance the entry of lentiviral vectors into human cells. Majdoul S, Cosette J, Seye AK, Bernard E, Frin S, Holic N, Chazal N, Briant L, Espert L, Galy A, Fenard D. J Biol Chem. 2017 Nov 10;292(45):18672-18681. doi: 10.1074/jbc.M117.800813. Epub 2017 Sep 19. PubMed
3-Decylcatechol induces autophagy-mediated cell death through the IRE1alpha/JNK/p62 in hepatocellular carcinoma cells. Go DH, Lee YG, Lee DH, Kim JA, Jo IH, Han YS, Jo YH, Kim KY, Seo YK, Moon JH, Jung CH, Jeon TI. Oncotarget. 2017 May 9;8(35):58790-58800. doi: 10.18632/oncotarget.17732. eCollection 2017 Aug 29. PubMed
BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells. Sulkshane P, Teni T. Oncotarget. 2016 Aug 5;8(36):60060-60079. doi: 10.18632/oncotarget.11085. eCollection 2017 Sep 1. PubMed
Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2). Jiao L, Zhang HL, Li DD, Yang KL, Tang J, Li X, Ji J, Yu Y, Wu RY, Ravichandran S, Liu JJ, Feng GK, Chen MS, Zeng YX, Deng R, Zhu XF. Autophagy. 2018;14(4):671-684. doi: 10.1080/15548627.2017.1381804. Epub 2017 Dec 17. PubMed
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed
alpha-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease. Baksi S, Singh N. Sci Rep. 2017 Oct 9;7(1):12843. doi: 10.1038/s41598-017-12862-x. PubMed
ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway. Dai B, Zhu F, Chen Y, Zhou R, Wang Z, Xie Y, Wu X, Zu S, Li G, Ge J, Chen F. Int J Mol Sci. 2017 Oct 11;18(10). pii: ijms18102125. doi: 10.3390/ijms18102125. PubMed
Effects of Ferroportin-Mediated Iron Depletion in Cells Representative of Different Histological Subtypes of Prostate Cancer. Deng Z, Manz DH, Torti SV, Torti FM. Antioxid Redox Signal. 2019 Mar 10;30(8):1043-1061. doi: 10.1089/ars.2017.7023. Epub 2017 Dec 11. PubMed
Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells. Sun T, Ming L, Yan Y, Zhang Y, Xue H. Oncotarget. 2017 Aug 19;8(43):74781-74790. doi: 10.18632/oncotarget.20367. eCollection 2017 Sep 26. PubMed
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Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K. Int J Oncol. 2018 Apr;52(4):1165-1177. doi: 10.3892/ijo.2018.4282. Epub 2018 Feb 23. PubMed
AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms. Nwadike C, Williamson LE, Gallagher LE, Guan JL, Chan EYW. Mol Cell Biol. 2018 Apr 30;38(10). pii: MCB.00023-18. doi: 10.1128/MCB.00023-18. Print 2018 May 15. PubMed
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Hypoxia-inducible factor-1alpha-dependent autophagy plays a role in glycolysis switch in mouse granulosa cells. Zhou J, Li C, Yao W, Alsiddig MC, Huo L, Liu H, Miao YL. Biol Reprod. 2018 Aug 1;99(2):308-318. doi: 10.1093/biolre/ioy061. PubMed
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy. Fan X, Weng Y, Bai Y, Wang Z, Wang S, Zhu J, Zhang F. Cancer Med. 2018 Jun;7(6):2541-2554. doi: 10.1002/cam4.1483. Epub 2018 Apr 16. PubMed
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM. Mol Cell. 2018 May 3;70(3):531-544.e9. doi: 10.1016/j.molcel.2018.03.037. PubMed
Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes. Gradzka S, Thomas OS, Kretz O, Haimovici A, Vasilikos L, Wong WW, Hacker G, Gentle IE. Cell Death Dis. 2018 May 1;9(5):529. doi: 10.1038/s41419-018-0508-y. PubMed
Interleukin-6 Reduces beta-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response. Marasco MR, Conteh AM, Reissaus CA, Cupit JE 5th, Appleman EM, Mirmira RG, Linnemann AK. Diabetes. 2018 Aug;67(8):1576-1588. doi: 10.2337/db17-1280. Epub 2018 May 21. PubMed
Autophagy, Cell Viability, and Chemoresistance Are Regulated By miR-489 in Breast Cancer. Soni M, Patel Y, Markoutsa E, Jie C, Liu S, Xu P, Chen H. Mol Cancer Res. 2018 Sep;16(9):1348-1360. doi: 10.1158/1541-7786.MCR-17-0634. Epub 2018 May 21. PubMed
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. Vera-Ramirez L, Vodnala SK, Nini R, Hunter KW, Green JE. Nat Commun. 2018 May 22;9(1):1944. doi: 10.1038/s41467-018-04070-6. PubMed
Aleuritolic Acid Impaired Autophagic Flux and Induced Apoptosis in Hepatocellular Carcinoma HepG2 Cells. Yi H, Wang K, Du B, He L, Ho H, Qiu M, Zou Y, Li Q, Jin J, Zhan Y, Zhao Z, Liu X. Molecules. 2018 Jun 2;23(6). pii: molecules23061338. doi: 10.3390/molecules23061338. PubMed
Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane. Wang Y, Mandal AK, Son YO, Pratheeshkumar P, Wise JTF, Wang L, Zhang Z, Shi X, Chen Z. Toxicol Appl Pharmacol. 2018 Aug 15;353:23-30. doi: 10.1016/j.taap.2018.06.003. Epub 2018 Jun 6. PubMed
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. Wang W, Xia Z, Farre JC, Subramani S. Autophagy. 2018;14(9):1574-1585. doi: 10.1080/15548627.2018.1463120. Epub 2018 Aug 21. PubMed
Varicella-zoster virus inhibits autophagosome-lysosome fusion and the degradation stage of mTOR-mediated autophagic flux. Graybill C, Morgan MJ, Levin MJ, Lee KS. Virology. 2018 Sep;522:220-227. doi: 10.1016/j.virol.2018.07.018. Epub 2018 Jul 24. PubMed
Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy. Peeters JGC, Picavet LW, Coenen SGJM, Mauthe M, Vervoort SJ, Mocholi E, de Heus C, Klumperman J, Vastert SJ, Reggiori F, Coffer PJ, Mokry M, van Loosdregt J. Autophagy. 2019 Jan;15(1):98-112. doi: 10.1080/15548627.2018.1509608. Epub 2018 Sep 11. PubMed
GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections. Kim JK, Kim YS, Lee HM, Jin HS, Neupane C, Kim S, Lee SH, Min JJ, Sasai M, Jeong JH, Choe SK, Kim JM, Yamamoto M, Choy HE, Park JB, Jo EK. Nat Commun. 2018 Oct 10;9(1):4184. doi: 10.1038/s41467-018-06487-5. PubMed
ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, Tan J, Chen T, Han H, Tian R, Tan Y, Wu Y, Cui J, Chen F, Li J, Lv L, Guan X, Shang S, Lu J, Zhang Z. J Cell Biol. 2019 Jan 7;218(1):267-284. doi: 10.1083/jcb.201804165. Epub 2018 Dec 11. PubMed
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux. Lu YT, Xiao YF, Li YF, Li J, Nan FJ, Li JY. Acta Pharmacol Sin. 2018 Dec 18. pii: 10.1038/s41401-018-0193-5. doi: 10.1038/s41401-018-0193-5. PubMed
The ULK1-FBXW5-SEC23B nexus controls autophagy. Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, Florens L, Washburn MP, Cavasotto CN, Fenyo D, Cuervo AM, Rossi M, Pagano M. Elife. 2018 Dec 31;7. pii: 42253. doi: 10.7554/eLife.42253. PubMed
Graphene Oxide Nanocolloids Induce Autophagy-Lysosome Dysfunction in Mouse Embryonic Stem Cells. Wei M, Fu Z, Wang C, Zheng W, Li S, Le W. J Biomed Nanotechnol. 2019 Feb 1;15(2):340-351. doi: 10.1166/jbn.2019.2684. PubMed
Imaging the Dynamics of Mitophagy in Live Cells. Moore AS, Holzbaur ELF. Methods Mol Biol. 2019;1880:601-610. doi: 10.1007/978-1-4939-8873-0_39. PubMed
Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. Elife. 2019 Feb 12;8. pii: 40811. doi: 10.7554/eLife.40811. PubMed
STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target von Hippel-Lindau-inactivated cells. Bouhamdani N, Comeau D, Cormier K, Turcotte S. Am J Physiol Cell Physiol. 2019 May 1;316(5):C605-C620. doi: 10.1152/ajpcell.00483.2018. Epub 2019 Feb 13. PubMed
SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Kim TS, Jin YB, Kim YS, Kim S, Kim JK, Lee HM, Suh HW, Choe JH, Kim YJ, Koo BS, Kim HN, Jung M, Lee SH, Kim DK, Chung C, Son JW, Min JJ, Kim JM, Deng CX, Kim HS, Lee SR, Jo EK. Autophagy. 2019 Aug;15(8):1356-1375. doi: 10.1080/15548627.2019.1582743. Epub 2019 Mar 4. PubMed
Protective autophagy elicited by RAF-->MEK-->ERK inhibition suggests a treatment strategy for RAS-driven cancers. Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW 3rd, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M. Nat Med. 2019 Apr;25(4):620-627. doi: 10.1038/s41591-019-0367-9. Epub 2019 Mar 4. PubMed
Protective autophagy decreases osimertinib cytotoxicity through regulation of stem cell-like properties in lung cancer. Li L, Wang Y, Jiao L, Lin C, Lu C, Zhang K, Hu C, Ye J, Zhang D, Wu H, Feng M, He Y. Cancer Lett. 2019 Jun 28;452:191-202. doi: 10.1016/j.canlet.2019.03.027. Epub 2019 Mar 22. PubMed
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability. Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Zeng X, Feldman RA, Lipinski MM. Autophagy. 2019 Apr 7:1-14. doi: 10.1080/15548627.2019.1598754. PubMed
Oleic acid-induced defective autolysosome shows impaired lipid degradation. Lee DH, Ahn J, Jang YJ, Ha TY, Jung CH. Biochem Biophys Res Commun. 2019 Jun 4;513(3):553-559. doi: 10.1016/j.bbrc.2019.04.040. Epub 2019 Apr 10. PubMed
Autophagy-induced senescence is regulated by p38alpha signaling. Slobodnyuk K, Radic N, Ivanova S, Llado A, Trempolec N, Zorzano A, Nebreda AR. Cell Death Dis. 2019 May 15;10(6):376. doi: 10.1038/s41419-019-1607-0. PubMed
Prosurvival autophagy is regulated by protein kinase CK1 alpha in multiple myeloma. Carrino M, Quotti Tubi L, Fregnani A, Canovas Nunes S, Barila G, Trentin L, Zambello R, Semenzato G, Manni S, Piazza F. Cell Death Discov. 2019 May 21;5:98. doi: 10.1038/s41420-019-0179-1. eCollection 2019. PubMed
Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination. Bankston AN, Forston MD, Howard RM, Andres KR, Smith AE, Ohri SS, Bates ML, Bunge MB, Whittemore SR. Glia. 2019 Sep;67(9):1745-1759. doi: 10.1002/glia.23646. Epub 2019 Jun 4. PubMed
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling. Lin Y, Wu C, Wang X, Liu S, Zhao K, Kemper T, Yu H, Li M, Zhang J, Chen M, Zhu Y, Chen X, Lu M. Autophagy. 2020 Mar;16(3):548-561. doi: 10.1080/15548627.2019.1632104. Epub 2019 Jun 23. PubMed
Junin virus induces autophagy in human A549 cells. Perez Vidakovics MLA, Ure AE, Arrias PN, Romanowski V, Gomez RM. PLoS One. 2019 Jun 19;14(6):e0218730. doi: 10.1371/journal.pone.0218730. eCollection 2019. PubMed
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM. Autophagy. 2019 Jun 25:1-20. doi: 10.1080/15548627.2019.1628538. PubMed
The novel small molecular BH3 mimetics SM3 and its regulation of cell apoptosis and autophagy. Wang Y, Fan S, Li X, Xiaokaiti Y, Pan Y, Tie L, Li X. Biochem Biophys Res Commun. 2019 Sep 10;517(1):15-22. doi: 10.1016/j.bbrc.2019.06.068. Epub 2019 Jul 11. PubMed
Serotonin receptor oligomerization regulates cAMP-based signaling. Prasad S, Ponimaskin E, Zeug A. J Cell Sci. 2019 Aug 23;132(16). pii: jcs.230334. doi: 10.1242/jcs.230334. PubMed
RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Barroso-Gonzalez J, Garcia-Exposito L, Hoang SM, Lynskey ML, Roncaioli JL, Ghosh A, Wallace CT, Modesti M, Bernstein KA, Sarkar SN, Watkins SC, O'Sullivan RJ. Mol Cell. 2019 Oct 3;76(1):11-26.e7. doi: 10.1016/j.molcel.2019.06.043. Epub 2019 Aug 7. PubMed
Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition. Denu RA, Kaur G, Sass MM, Lakkaraju A, Burkard ME. Mol Cancer Res. 2020 Jan;18(1):33-45. doi: 10.1158/1541-7786.MCR-19-0509. Epub 2019 Oct 11. PubMed
Caffeic acid reduces A53T alpha-synuclein by activating JNK/Bcl-2-mediated autophagy in vitro and improves behaviour and protects dopaminergic neurons in a mouse model of Parkinson's disease. Zhang Y, Wu Q, Zhang L, Wang Q, Yang Z, Liu J, Feng L. Pharmacol Res. 2019 Dec;150:104538. doi: 10.1016/j.phrs.2019.104538. Epub 2019 Nov 9. PubMed
Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. Lee DH, Park SH, Huh YH, Jung Kim M, Seo HD, Ha TY, Ahn J, Jang YJ, Jung CH. Biomed Pharmacother. 2020 May;125:109950. doi: 10.1016/j.biopha.2020.109950. Epub 2020 Feb 10. PubMed
Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms. Towers CG, Wodetzki D, Thorburn A. Autophagy. 2020 Jul;16(7):1332-1340. doi: 10.1080/15548627.2020.1741204. Epub 2020 Mar 18. PubMed
CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis. Dobson-Stone C, Hallupp M, Shahheydari H, Ragagnin AMG, Chatterton Z, Carew-Jones F, Shepherd CE, Stefen H, Paric E, Fath T, Thompson EM, Blumbergs P, Short CL, Field CD, Panegyres PK, Hecker J, Nicholson G, Shaw AD, Fullerton JM, Luty AA, Schofield PR, Brooks WS, Rajan N, Bennett MF, Bahlo M, Landers JE, Piguet O, Hodges JR, Halliday GM, Topp SD, Smith BN, Shaw CE, McCann E, Fifita JA, Williams KL, Atkin JD, Blair IP, Kwok JB. Brain. 2020 Mar 1;143(3):783-799. doi: 10.1093/brain/awaa039. PubMed
Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma. Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Nat Cell Biol. 2020 Apr;22(4):412-424. doi: 10.1038/s41556-020-0481-4. Epub 2020 Mar 16. PubMed
Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy. Chen Y, Wang H, Ying Z, Gao Q. Biochem Biophys Res Commun. 2020 May 21;526(1):231-238. doi: 10.1016/j.bbrc.2020.03.051. Epub 2020 Mar 21. PubMed
Autophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-beta/Smad3 signaling in melanoma cells. Bao Y, Ding Z, Zhao P, Li J, Chen P, Zheng J, Qian Z. Cell Death Dis. 2020 Apr 7;11(4):223. doi: 10.1038/s41419-020-2419-y. PubMed
EGCG protects vascular endothelial cells from oxidative stress-induced damage by targeting the autophagy-dependent PI3K-AKT-mTOR pathway. Meng J, Chen Y, Wang J, Qiu J, Chang C, Bi F, Wu X, Liu W. Ann Transl Med. 2020 Mar;8(5):200. doi: 10.21037/atm.2020.01.92. PubMed
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitic T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A. EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192. Epub 2020 Apr 26. PubMed
Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue. Son Y, Cho YK, Saha A, Kwon HJ, Park JH, Kim M, Jung YS, Kim SN, Choi C, Seong JK, Burl RB, Granneman JG, Lee YH. Mol Metab. 2020 Sep;39:101005. doi: 10.1016/j.molmet.2020.101005. Epub 2020 Apr 25. PubMed
Activated CAMKKbeta-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis. Laski J, Singha B, Wang X, Valdes YR, Collins O, Shepherd TG. J Ovarian Res. 2020 May 11;13(1):58. doi: 10.1186/s13048-020-00660-5. PubMed
Inhibiting ULK1 kinase decreases autophagy and cell viability in high-grade serous ovarian cancer spheroids. Singha B, Laski J, Ramos Valdes Y, Liu E, DiMattia GE, Shepherd TG. Am J Cancer Res. 2020 May 1;10(5):1384-1399. eCollection 2020. PubMed
Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H. Cells. 2020 Jun 5;9(6). pii: cells9061406. doi: 10.3390/cells9061406. PubMed Associated Plasmids P-Ef1a-RPL22-3XHA-P2A-EGFP-T2A-Puro P-Ef1a-RPL22-3XFlag-P2A-EGFP-T2A-Puro P-Ef1a-RPL22-3XHA-P2A-EGFP-T2A-Neo P-Ef1a-RPL22-3XHA-P2A-mCherry-T2A-Puro P-Ef1a-RPL22-3XHA-P2A-mCherry-T2A-Neo More ...
Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation. Xie L, Hu WY, Hu DP, Shi G, Li Y, Yang J, Prins GS. Environ Health Perspect. 2020 Jun;128(6):67008. doi: 10.1289/EHP6471. Epub 2020 Jun 11. PubMed
Hydroxychloroquine-loaded hollow mesoporous silica nanoparticles for enhanced autophagy inhibition and radiation therapy. Li Y, Cho MH, Lee SS, Lee DE, Cheong H, Choi Y. J Control Release. 2020 Sep 10;325:100-110. doi: 10.1016/j.jconrel.2020.06.025. Epub 2020 Jul 1. PubMed
GSK-3beta inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative activity in human neuroblastoma cells. Song HC, Chen Y, Chen Y, Park J, Zheng M, Surh YJ, Kim UH, Park JW, Yu R, Chung HT, Joe Y. Free Radic Res. 2020 Jul 28:1-13. doi: 10.1080/10715762.2020.1791843. PubMed
An improved method for high-throughput quantification of autophagy in mammalian cells. Koepke L, Winter B, Grenzner A, Regensburger K, Engelhart S, van der Merwe JA, Krebs S, Blum H, Kirchhoff F, Sparrer KMJ. Sci Rep. 2020 Jul 22;10(1):12241. doi: 10.1038/s41598-020-68607-w. PubMed
Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Wang K, Liu X, Liu Q, Ho IH, Wei X, Yin T, Zhan Y, Zhang W, Zhang W, Chen B, Gu J, Tan Y, Zhang L, Chan MT, Wu WK, Du B, Xiao J. Cell Death Dis. 2020 Aug 13;11(8):611. doi: 10.1038/s41419-020-02880-5. PubMed
O-GlcNAcylation modulates HBV replication through regulating cellular autophagy at multiple levels. Wang X, Lin Y, Liu S, Zhu Y, Lu K, Broering R, Lu M. FASEB J. 2020 Nov;34(11):14473-14489. doi: 10.1096/fj.202001168RR. Epub 2020 Sep 6. PubMed
Autophagy induction promotes renal cyst growth in polycystic kidney disease. Lee EJ, Ko JY, Oh S, Jun J, Mun H, Lim CJ, Seo S, Ko HW, Kim H, Oh YK, Ahn C, Kang M, Kim MJ, Yoo KH, Oh GT, Park JH. EBioMedicine. 2020 Oct;60:102986. doi: 10.1016/j.ebiom.2020.102986. Epub 2020 Sep 16. PubMed
SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation. Fang C, Woo JA, Liu T, Zhao X, Cazzaro S, Yan Y, Matlack J, Kee T, LePochat P, Kang DE. Autophagy. 2021 Sep;17(9):2144-2165. doi: 10.1080/15548627.2020.1816663. Epub 2020 Oct 12. PubMed
ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Kim S, Lee JY, Shin SG, Kim JK, Silwal P, Kim YJ, Shin NR, Kim PS, Won M, Lee SH, Kim SY, Sasai M, Yamamoto M, Kim JM, Bae JW, Jo EK. Autophagy. 2021 Oct;17(10):2856-2875. doi: 10.1080/15548627.2020.1847460. Epub 2020 Dec 15. PubMed
A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress. Arora K, Liyanage P, Zhong Q, Naren AP. FASEB J. 2021 Feb;35(2):e21185. doi: 10.1096/fj.201903210R. Epub 2020 Nov 15. PubMed
The apple dihydrochalcone phloretin suppresses growth and improves chemosensitivity of breast cancer cells via inhibition of cytoprotective autophagy. Chen M, Gowd V, Wang M, Chen F, Cheng KW. Food Funct. 2021 Jan 7;12(1):177-190. doi: 10.1039/d0fo02362k. Epub 2020 Dec 8. PubMed
Curcumin ameliorates IL-1beta-induced apoptosis by activating autophagy and inhibiting the NF-kappaB signaling pathway in rat primary articular chondrocytes. Chen T, Zhou R, Chen Y, Fu W, Wei X, Ma G, Hu W, Lu C. Cell Biol Int. 2021 May;45(5):976-988. doi: 10.1002/cbin.11541. Epub 2021 Jan 25. PubMed
Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition. Zhou L, He R, Fang P, Li M, Yu H, Wang Q, Yu Y, Wang F, Zhang Y, Chen A, Peng N, Lin Y, Zhang R, Trilling M, Broering R, Lu M, Zhu Y, Liu S. Nat Commun. 2021 Jan 4;12(1):98. doi: 10.1038/s41467-020-20316-8. PubMed
Autophagy-enhancing drugs limit mucosal HIV-1 acquisition and suppress viral replication ex vivo. Cloherty APM, van Teijlingen NH, Eisden TTHD, van Hamme JL, Rader AG, Geijtenbeek TBH, Schreurs RRCE, Ribeiro CMS. Sci Rep. 2021 Feb 26;11(1):4767. doi: 10.1038/s41598-021-84081-4. PubMed
Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice. Silwal P, Kim JK, Jeon SM, Lee JY, Kim YJ, Kim YS, Seo Y, Kim J, Kim SY, Lee MJ, Heo JY, Jung MJ, Kim HS, Hyun DW, Han JE, Whang J, Huh YH, Lee SH, Heo WD, Kim JM, Bae JW, Jo EK. Commun Biol. 2021 May 10;4(1):548. doi: 10.1038/s42003-021-02073-6. PubMed
Chinese herbal medicine Feiyanning cooperates with cisplatin to enhance cytotoxicity to non-small-cell lung cancer by inhibiting protective autophagy. Zheng Z, Ma Y, Wang L, Deng H, Wang Z, Li J, Xu Z. J Ethnopharmacol. 2021 Aug 10;276:114196. doi: 10.1016/j.jep.2021.114196. Epub 2021 May 11. PubMed
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