Skip to main content
This website uses cookies to ensure you get the best experience. By continuing to use this site, you agree to the use of cookies.

Please note: Your browser does not support the features used on Addgene's website. You may not be able to create an account or request plasmids through this website until you upgrade your browser. Learn more

Please note: Your browser does not fully support some of the features used on Addgene's website. If you run into any problems registering, depositing, or ordering please contact us at [email protected] Learn more

pEGFP-LC3 (human) Citations (53)

Plasmid Article: A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T Proc Natl Acad Sci U S A. 2008 Mar 4. 105(9):3374-9.
PubMed Journal

Articles Citing pEGFP-LC3 (human)

Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells. Duan L, Motchoulski N, Danzer B, Davidovich I, Shariat-Madar Z, Levenson VV. J Biol Chem. 2011 Jan 28;286(4):2864-76. doi: 10.1074/jbc.M110.143271. Epub 2010 Nov 17. PubMed
Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. Liu H, Yu S, Zhang H, Xu J. PLoS One. 2012;7(10):e46720. doi: 10.1371/journal.pone.0046720. Epub 2012 Oct 3. PubMed
Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells. Zhang Q, Si S, Schoen S, Chen J, Jin XB, Wu G. J Exp Clin Cancer Res. 2013 Dec 4;32:99. doi: 10.1186/1756-9966-32-99. PubMed
Folliculin deficient renal cancer cells show higher radiosensitivity through autophagic cell death. Zhang Q, Si S, Schoen S, Jin XB, Chen J, Wu G. J Urol. 2014 Jun;191(6):1880-8. doi: 10.1016/j.juro.2014.01.001. Epub 2014 Jan 13. PubMed
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer. Wang M, Shim JS, Li RJ, Dang Y, He Q, Das M, Liu JO. Br J Pharmacol. 2014 Oct;171(19):4478-89. doi: 10.1111/bph.12800. Epub 2014 Sep 5. PubMed
Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors. Yeh ES, Abt MA, Hill EG. Breast Cancer Res Treat. 2015 Jan;149(1):91-8. doi: 10.1007/s10549-014-3227-9. Epub 2014 Dec 17. PubMed
A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis. Buratta S, Urbanelli L, Ferrara G, Sagini K, Goracci L, Emiliani C. Biochem Pharmacol. 2015 Jun 1;95(3):201-9. doi: 10.1016/j.bcp.2015.03.017. Epub 2015 Apr 13. PubMed
The GST-BHMT assay reveals a distinct mechanism underlying proteasome inhibition-induced macroautophagy in mammalian cells. Rui YN, Xu Z, Chen Z, Zhang S. Autophagy. 2015;11(5):812-32. doi: 10.1080/15548627.2015.1034402. PubMed
N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Metge BJ, Mitra A, Chen D, Shevde LA, Samant RS. Sci Rep. 2015 Jul 6;5:11995. doi: 10.1038/srep11995. PubMed
A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy. Pandhare J, Dash S, Jones B, Villalta F, Dash C. J Biol Chem. 2015 Oct 16;290(42):25439-51. doi: 10.1074/jbc.M115.652776. Epub 2015 Sep 1. PubMed
Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1alpha-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Tang ZH, Zhang LL, Li T, Lu JH, Ma DL, Leung CH, Chen XP, Jiang HL, Wang YT, Lu JJ. Oncotarget. 2015 Dec 22;6(41):43911-26. doi: 10.18632/oncotarget.6084. PubMed
Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells. Liu XY, He YJ, Yang QH, Huang W, Liu ZH, Ye GR, Tang SH, Shu JC. Am J Cancer Res. 2015 Aug 15;5(9):2569-89. eCollection 2015. PubMed
EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex. Lei Y, Kansy BA, Li J, Cong L, Liu Y, Trivedi S, Wen H, Ting JP, Ouyang H, Ferris RL. Oncogene. 2016 Feb 15. doi: 10.1038/onc.2016.11. PubMed
Dose-dependent autophagic effect of titanium dioxide nanoparticles in human HaCaT cells at non-cytotoxic levels. Lopes VR, Loitto V, Audinot JN, Bayat N, Gutleb AC, Cristobal S. J Nanobiotechnology. 2016 Mar 22;14:22. doi: 10.1186/s12951-016-0174-0. PubMed
Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells. Xia T, Wang J, Wang Y, Wang Y, Cai J, Wang M, Chen Q, Song J, Yu Z, Huang W, Fang J. Oncotarget. 2016 May 10;7(19):27336-49. doi: 10.18632/oncotarget.8285. PubMed
Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Tang ZH, Chen X, Wang ZY, Chai K, Wang YF, Xu XH, Wang XW, Lu JH, Wang YT, Chen XP, Lu JJ. Sci Rep. 2016 May 17;6:26241. doi: 10.1038/srep26241. PubMed
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. O'Donnell JC, Jackson JG, Robinson MB. J Neurosci. 2016 Jul 6;36(27):7109-27. doi: 10.1523/JNEUROSCI.4518-15.2016. PubMed
AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production. Mahil SK, Twelves S, Farkas K, Setta-Kaffetzi N, Burden AD, Gach JE, Irvine AD, Kepiro L, Mockenhaupt M, Oon HH, Pinner J, Ranki A, Seyger MM, Soler-Palacin P, Storan ER, Tan ES, Valeyrie-Allanore L, Young HS, Trembath RC, Choon SE, Szell M, Bata-Csorgo Z, Smith CH, Di Meglio P, Barker JN, Capon F. J Invest Dermatol. 2016 Nov;136(11):2251-2259. doi: 10.1016/j.jid.2016.06.618. Epub 2016 Jul 5. PubMed
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Felix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J. Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11. PubMed
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome. Cagalinec M, Liiv M, Hodurova Z, Hickey MA, Vaarmann A, Mandel M, Zeb A, Choubey V, Kuum M, Safiulina D, Vasar E, Veksler V, Kaasik A. PLoS Biol. 2016 Jul 19;14(7):e1002511. doi: 10.1371/journal.pbio.1002511. eCollection 2016 Jul. PubMed
Transient Proteotoxicity of Bacterial Virulence Factor Pyocyanin in Renal Tubular Epithelial Cells Induces ER-Related Vacuolation and Can Be Efficiently Modulated by Iron Chelators. Mossine VV, Waters JK, Chance DL, Mawhinney TP. Toxicol Sci. 2016 Dec;154(2):403-415. Epub 2016 Sep 9. PubMed
A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Wei RJ, Lin SS, Wu WR, Chen LR, Li CF, Chen HD, Chou CT, Chen YC, Liang SS, Chien ST, Shiue YL. Toxicol Appl Pharmacol. 2016 Nov 15;311:88-98. doi: 10.1016/j.taap.2016.09.021. Epub 2016 Sep 24. PubMed
Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis. Coly PM, Perzo N, Le Joncour V, Lecointre C, Schouft MT, Desrues L, Tonon MC, Wurtz O, Gandolfo P, Castel H, Morin F. Autophagy. 2016 Dec;12(12):2344-2362. Epub 2016 Oct 7. PubMed
Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192. Shyu RY, Wang CH, Wu CC, Chen ML, Lee MC, Wang LK, Jiang SY, Tsai FM. Mol Cells. 2016 Dec;39(12):877-887. doi: 10.14348/molcells.2016.0161. Epub 2016 Dec 13. PubMed
Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Liu YH, Weng YP, Lin HY, Tang SW, Chen CJ, Liang CJ, Ku CY, Lin JY. Sci Rep. 2017 Jan 30;7:41437. doi: 10.1038/srep41437. PubMed
Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. Li W, Reeb AN, Lin B, Subramanian P, Fey EE, Knoverek CR, French RL, Bigio EH, Ayala YM. J Biol Chem. 2017 Mar 24;292(12):5089-5100. doi: 10.1074/jbc.M116.753913. Epub 2017 Feb 6. PubMed
Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. Liu Y, Gong W, Yang ZY, Zhou XS, Gong C, Zhang TR, Wei X, Ma D, Ye F, Gao QL. Apoptosis. 2017 Apr;22(4):544-557. doi: 10.1007/s10495-016-1334-2. PubMed
Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells. Tang ZH, Cao WX, Su MX, Chen X, Lu JJ. Toxicol Appl Pharmacol. 2017 Apr 15;321:18-26. doi: 10.1016/j.taap.2017.02.017. Epub 2017 Feb 22. PubMed
Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. Son YO, Pratheeshkumar P, Divya SP, Zhang Z, Shi X. J Biol Chem. 2017 May 19;292(20):8315-8330. doi: 10.1074/jbc.M116.773986. Epub 2017 Mar 22. PubMed
Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme. Wang L, Gundelach JH, Bram RJ. Cell Death Dis. 2017 May 18;8(5):e2807. doi: 10.1038/cddis.2017.217. PubMed
HCV-induced oxidative stress by inhibition of Nrf2 triggers autophagy and favors release of viral particles. Medvedev R, Ploen D, Spengler C, Elgner F, Ren H, Bunten S, Hildt E. Free Radic Biol Med. 2017 Sep;110:300-315. doi: 10.1016/j.freeradbiomed.2017.06.021. Epub 2017 Jun 30. PubMed
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, Cordes T, Duran A, Reina-Campos M, Valencia T, Ahn CS, Castilla EA, Moscat J, Metallo CM, Diaz-Meco MT. Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5. PubMed
Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Tang ZH, Cao WX, Guo X, Dai XY, Lu JH, Chen X, Zhu H, Lu JJ. Cancer Lett. 2018 Jan 1;412:1-9. doi: 10.1016/j.canlet.2017.10.001. Epub 2017 Oct 9. PubMed
Simultaneous Detection of Autophagy and Epithelial to Mesenchymal Transition in the Non-small Cell Lung Cancer Cells. Alizadeh J, Shojaei S, Sepanjnia A, Hashemi M, Eftekharpour E, Ghavami S. Methods Mol Biol. 2017 Nov 4. doi: 10.1007/7651_2017_84. PubMed
Ferroquine, the next generation antimalarial drug, has antitumor activity. Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon RA, Slomianny C, Lemiere S, Delcourt P, Dewailly E, Skryma R, Biot C, Prevarskaya N. Sci Rep. 2017 Nov 21;7(1):15896. doi: 10.1038/s41598-017-16154-2. PubMed
CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation. Mishra SK, Gao YG, Deng Y, Chalfant CE, Hinchcliffe EH, Brown RE. Autophagy. 2018 Feb 21:1-18. doi: 10.1080/15548627.2017.1393129. PubMed
Combined pitavastatin and dacarbazine treatment activates apoptosis and autophagy resulting in synergistic cytotoxicity in melanoma cells. Al-Qatati A, Aliwaini S. Oncol Lett. 2017 Dec;14(6):7993-7999. doi: 10.3892/ol.2017.7189. Epub 2017 Oct 16. PubMed
Polysaccharide from Fuzi protects against OxLDLinduced calcification of human vascular smooth muscle cells by increasing autophagic activity. Liao L, Zhuang X, Li W, Su Q, Zhao J, Liu Y. Mol Med Rep. 2018 Apr;17(4):5109-5115. doi: 10.3892/mmr.2018.8488. Epub 2018 Jan 25. PubMed
Inhibition of autophagy-attenuated calcium oxalate crystal-induced renal tubular epithelial cell injury in vivo and in vitro. Liu Y, Li D, He Z, Liu Q, Wu J, Guan X, Tao Z, Deng Y. Oncotarget. 2017 Dec 17;9(4):4571-4582. doi: 10.18632/oncotarget.23383. eCollection 2018 Jan 12. PubMed
IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth. Yang R, Yang E, Shen L, Modlin RL, Shen H, Chen ZW. J Immunol. 2018 Apr 1;200(7):2405-2417. doi: 10.4049/jimmunol.1701073. Epub 2018 Feb 16. PubMed
Rab9-dependent autophagy is required for the IGF-IIR triggering mitophagy to eliminate damaged mitochondria. Huang CY, Kuo WW, Ho TJ, Chiang SF, Pai PY, Lin JY, Lin DY, Kuo CH, Huang CY. J Cell Physiol. 2018 Sep;233(9):7080-7091. doi: 10.1002/jcp.26346. Epub 2018 Mar 25. PubMed
Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine. Tan YS, Sansanaphongpricha K, Xie Y, Donnelly CR, Luo X, Heath BR, Zhao X, Bellile E, Hu H, Chen H, Polverini PJ, Chen Q, Young S, Carey TE, Nor JE, Ferris RL, Wolf GT, Sun D, Lei YL. Clin Cancer Res. 2018 Sep 1;24(17):4242-4255. doi: 10.1158/1078-0432.CCR-17-2807. Epub 2018 May 16. PubMed
Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane. Wang Y, Mandal AK, Son YO, Pratheeshkumar P, Wise JTF, Wang L, Zhang Z, Shi X, Chen Z. Toxicol Appl Pharmacol. 2018 Aug 15;353:23-30. doi: 10.1016/j.taap.2018.06.003. Epub 2018 Jun 6. PubMed
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts. Torralba D, Baixauli F, Villarroya-Beltri C, Fernandez-Delgado I, Latorre-Pellicer A, Acin-Perez R, Martin-Cofreces NB, Jaso-Tamame AL, Iborra S, Jorge I, Gonzalez-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enriquez JA, Mittelbrunn M, Sanchez-Madrid F. Nat Commun. 2018 Jul 9;9(1):2658. doi: 10.1038/s41467-018-05077-9. PubMed
Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells. Yang F, Wang F, Liu Y, Wang S, Li X, Huang Y, Xia Y, Cao C. Life Sci. 2018 Nov 15;213:149-157. doi: 10.1016/j.lfs.2018.10.034. Epub 2018 Oct 20. PubMed
Autophagy modulates temozolomide-induced cell death in alveolar Rhabdomyosarcoma cells. Moghadam AR, da Silva Rosa SC, Samiei E, Alizadeh J, Field J, Kawalec P, Thliveris J, Akbari M, Ghavami S, Gordon JW. Cell Death Discov. 2018 Oct 25;4:52. doi: 10.1038/s41420-018-0115-9. eCollection 2018. PubMed
Cigarette smoke induces ROS mediated autophagy impairment in human corneal epithelial cells. Miao Q, Xu Y, Zhang H, Xu P, Ye J. Environ Pollut. 2019 Feb;245:389-397. doi: 10.1016/j.envpol.2018.11.028. Epub 2018 Nov 9. PubMed
Miro proteins prime mitochondria for Parkin translocation and mitophagy. Safiulina D, Kuum M, Choubey V, Gogichaishvili N, Liiv J, Hickey MA, Cagalinec M, Mandel M, Zeb A, Liiv M, Kaasik A. EMBO J. 2019 Jan 15;38(2). pii: embj.201899384. doi: 10.15252/embj.201899384. Epub 2018 Nov 30. PubMed
A VPS33A-binding motif on syntaxin 17 controls autophagy completion in mammalian cells. Saleeb RS, Kavanagh DM, Dun AR, Dalgarno PA, Duncan RR. J Biol Chem. 2019 Mar 15;294(11):4188-4201. doi: 10.1074/jbc.RA118.005947. Epub 2019 Jan 17. PubMed
Recombinant adenoviruses expressing apoptin suppress the growth of MCF7 breast cancer cells and affect cell autophagy. Chen S, Li YQ, Yin XZ, Li SZ, Zhu YL, Fan YY, Li WJ, Cui YL, Zhao J, Li X, Zhang QG, Jin NY. Oncol Rep. 2019 May;41(5):2818-2832. doi: 10.3892/or.2019.7077. Epub 2019 Mar 18. PubMed
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. Fernandez-Mosquera L, Yambire KF, Couto R, Pereyra L, Pabis K, Ponsford AH, Diogo CV, Stagi M, Milosevic I, Raimundo N. Autophagy. 2019 Sep;15(9):1572-1591. doi: 10.1080/15548627.2019.1586256. Epub 2019 Mar 27. PubMed
The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, Seki A, Shen K, Iyer H, Han K, Hayer A, Wollman R, Ge X, Lin JR, Dey G, Talbot WS, Meyer T. Nat Cell Biol. 2019 May;21(5):614-626. doi: 10.1038/s41556-019-0321-6. Epub 2019 Apr 29. PubMed
PRRSV activates lipophagy to facilitate viral replication through down-regulation of NDRG1 expression. Wang J, Liu JY, Shao KY, Han YQ, Li GL, Ming SL, Su BQ, Du YK, Liu ZH, Zhang GP, Yang GY, Chu BB. J Virol. 2019 Jun 12. pii: JVI.00526-19. doi: 10.1128/JVI.00526-19. PubMed

If you have published an article using this plasmid, please email us at [email protected] to have your article added to this page.