pT7-7 asyn WT Citations (46)
Originally described in: Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA J Biol Chem. 2008 Jun 13;283(24):16895-905. Epub 2008 Mar 14. PubMed Journal
Articles Citing pT7-7 asyn WT
| Articles |
|---|
| Role of Sporadic Parkinson Disease Associated Mutations A18T and A29S in Enhanced alpha-Synuclein Fibrillation and Cytotoxicity. Kumar S, Jangir DK, Kumar R, Kumari M, Bhavesh NS, Maiti TK. ACS Chem Neurosci. 2018 Feb 21;9(2):230-240. doi: 10.1021/acschemneuro.6b00430. Epub 2017 Sep 6. PubMed |
| On the efficient bio-incorporation of 5-hydroxy-tryptophan in recombinant proteins expressed in Escherichia coli with T7 RNA polymerase-based vectors. Oliveira-Souza WP, Bronze F, Broos J, Marcondes MFM, Oliveira V. Biochem Biophys Res Commun. 2017 Oct 21;492(3):343-348. doi: 10.1016/j.bbrc.2017.08.111. Epub 2017 Aug 30. PubMed |
| alpha-Synuclein Aggregation Monitored by Thioflavin T Fluorescence Assay. Wordehoff MM, Hoyer W. Bio Protoc. 2018 Jul 20;8(14). doi: 10.21769/BioProtoc.2941. PubMed |
| Probing Alpha-Synuclein Conformations by Electron Paramagnetic Resonance (EPR) Spectroscopy. Cattani J, Braun T, Drescher M. Methods Mol Biol. 2019;1948:247-260. doi: 10.1007/978-1-4939-9124-2_19. PubMed |
| Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme. Cliffe R, Sang JC, Kundel F, Finley D, Klenerman D, Ye Y. Cell Rep. 2019 Feb 19;26(8):2140-2149.e3. doi: 10.1016/j.celrep.2019.01.096. PubMed |
| Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates alpha-synuclein aggregation in vitro. Ardah MT, Merghani MM, Haque ME. Neurochem Int. 2019 Sep;128:115-126. doi: 10.1016/j.neuint.2019.04.014. Epub 2019 Apr 24. PubMed |
| Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease. Sanyal A, Dutta S, Camara A, Chandran A, Koller A, Watson BG, Sengupta R, Ysselstein D, Montenegro P, Cannon J, Rochet JC, Mattoo S. J Mol Biol. 2019 May 31;431(12):2266-2282. doi: 10.1016/j.jmb.2019.04.026. Epub 2019 Apr 27. PubMed |
| alpha-Synuclein chaperone suppresses nucleation and amyloidogenesis of prion protein. Shirasaka M, Kuwata K, Honda R. Biochem Biophys Res Commun. 2020 Jan 1;521(1):259-264. doi: 10.1016/j.bbrc.2019.10.120. Epub 2019 Oct 18. PubMed |
| Partially oxidized DJ-1 inhibits alpha-synuclein nucleation and remodels mature alpha-synuclein fibrils in vitro. Kumar R, Kumar S, Hanpude P, Singh AK, Johari T, Majumder S, Maiti TK. Commun Biol. 2019 Oct 30;2:395. doi: 10.1038/s42003-019-0644-7. eCollection 2019. PubMed |
| Real-Time 3D Imaging and Inhibition Analysis of Various Amyloid Aggregations Using Quantum Dots. Lin X, Galaqin N, Tainaka R, Shimamori K, Kuragano M, Noguchi TQP, Tokuraku K. Int J Mol Sci. 2020 Mar 13;21(6). pii: ijms21061978. doi: 10.3390/ijms21061978. PubMed |
| DIBMA nanodiscs keep alpha-synuclein folded. Adao R, Cruz PF, Vaz DC, Fonseca F, Pedersen JN, Ferreira-da-Silva F, Brito RMM, Ramos CHI, Otzen D, Keller S, Bastos M. Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183314. doi: 10.1016/j.bbamem.2020.183314. Epub 2020 Apr 15. PubMed |
| Self- and Cross-Seeding on alpha-Synuclein Fibril Growth Kinetics and Structure Observed by High-Speed Atomic Force Microscopy. Watanabe-Nakayama T, Nawa M, Konno H, Kodera N, Ando T, Teplow DB, Ono K. ACS Nano. 2020 Aug 25;14(8):9979-9989. doi: 10.1021/acsnano.0c03074. Epub 2020 Aug 4. PubMed |
| Real-time 3D single molecule tracking. Hou S, Exell J, Welsher K. Nat Commun. 2020 Jul 17;11(1):3607. doi: 10.1038/s41467-020-17444-6. PubMed |
| Toxic Metamorphosis-How Changes from Lysosomal to Cytosolic pH Modify the Alpha-Synuclein Aggregation Pattern. Eymsh B, Drobny A, Heyn TR, Xiang W, Lucius R, Schwarz K, Keppler JK, Zunke F, Arnold P. Biomacromolecules. 2020 Dec 14;21(12):4673-4684. doi: 10.1021/acs.biomac.0c00629. Epub 2020 Oct 13. PubMed |
| Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of alpha-synuclein. Merghani MM, Ardah MT, Al Shamsi M, Kitada T, Haque ME. Neurotoxicology. 2021 May;84:41-52. doi: 10.1016/j.neuro.2021.02.001. Epub 2021 Feb 4. PubMed |
| Protein in-cell NMR spectroscopy at 1.2 GHz. Luchinat E, Barbieri L, Cremonini M, Banci L. J Biomol NMR. 2021 Mar;75(2-3):97-107. doi: 10.1007/s10858-021-00358-w. Epub 2021 Feb 12. PubMed |
| Identification of Natural Products as Potential Pharmacological Chaperones for Protein Misfolding Diseases. Sharma R, Srivastava T, Pandey AR, Mishra T, Gupta B, Reddy SS, Singh SP, Narender T, Tripathi A, Chandramouli B, Sashidhara KV, Priya S, Kumar N. ChemMedChem. 2021 Jul 6;16(13):2146-2156. doi: 10.1002/cmdc.202100147. Epub 2021 May 4. PubMed |
| In situ architecture of neuronal alpha-Synuclein inclusions. Trinkaus VA, Riera-Tur I, Martinez-Sanchez A, Bauerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernandez-Busnadiego R. Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0. PubMed |
| Ellagic Acid Inhibits alpha-Synuclein Aggregation at Multiple Stages and Reduces Its Cytotoxicity. Kumar S, Kumar R, Kumari M, Kumari R, Saha S, Bhavesh NS, Maiti TK. ACS Chem Neurosci. 2021 Jun 2;12(11):1919-1930. doi: 10.1021/acschemneuro.1c00001. Epub 2021 May 20. PubMed |
| Molecular insights into alpha-synuclein interaction with individual human core histones, linker histone, and dsDNA. Jos S, Gogoi H, Prasad TK, Hurakadli MA, Kamariah N, Padmanabhan B, Padavattan S. Protein Sci. 2021 Oct;30(10):2121-2131. doi: 10.1002/pro.4167. Epub 2021 Aug 19. PubMed |
| Ellagic Acid Prevents alpha-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated alpha-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy. Ardah MT, Eid N, Kitada T, Haque ME. Int J Mol Sci. 2021 Dec 13;22(24). pii: ijms222413398. doi: 10.3390/ijms222413398. PubMed |
| Single Molecule Fingerprinting Reveals Different Amplification Properties of alpha-Synuclein Oligomers and Preformed Fibrils in Seeding Assay. Lau D, Magnan C, Hill K, Cooper A, Gambin Y, Sierecki E. ACS Chem Neurosci. 2022 Apr 6;13(7):883-896. doi: 10.1021/acschemneuro.1c00553. Epub 2022 Mar 14. PubMed |
| Lipids and EGCG Affect alpha-Synuclein Association and Disruption of Nanodiscs. Sanders HM, Kostelic MM, Zak CK, Marty MT. Biochemistry. 2022 Jun 7;61(11):1014-1021. doi: 10.1021/acs.biochem.2c00160. Epub 2022 May 26. PubMed |
| Detection of neuron-derived pathological alpha-synuclein in blood. Kluge A, Bunk J, Schaeffer E, Drobny A, Xiang W, Knacke H, Bub S, Luckstadt W, Arnold P, Lucius R, Berg D, Zunke F. Brain. 2022 Sep 14;145(9):3058-3071. doi: 10.1093/brain/awac115. PubMed |
| Modulation of alpha-Synuclein Aggregation In Vitro by a DNA Aptamer. Tran CH, Saha R, Blanco C, Bagchi D, Chen IA. Biochemistry. 2022 Sep 6;61(17):1757-1765. doi: 10.1021/acs.biochem.2c00207. Epub 2022 Aug 22. PubMed |
| Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation. Pieger K, Schmitt V, Gauer C, Giessl N, Prots I, Winner B, Winkler J, Brandstatter JH, Xiang W. Biomolecules. 2022 Aug 12;12(8):1108. doi: 10.3390/biom12081108. PubMed |
| Toward high-throughput oligomer detection and classification for early-stage aggregation of amyloidogenic protein. Tahirbegi B, Magness AJ, Piersimoni ME, Teng X, Hooper J, Guo Y, Knopfel T, Willison KR, Klug DR, Ying L. Front Chem. 2022 Aug 30;10:967882. doi: 10.3389/fchem.2022.967882. eCollection 2022. PubMed |
| Differential interactions of alpha-synuclein conformers affect refolding and activity of proteins. Bagree G, Srivastava T, Mahasivam S, Sinha M, Bansal V, Ramanathan R, Priya S, Sharma SK. J Biochem. 2023 Feb 3;173(2):107-114. doi: 10.1093/jb/mvac095. PubMed |
| Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders. Brauer S, Rossi M, Sajapin J, Henle T, Gasser T, Parchi P, Brockmann K, Falkenburger BH. Acta Neuropathol Commun. 2023 Oct 9;11(1):162. doi: 10.1186/s40478-023-01653-3. PubMed |
| Thermodynamic characterization of amyloid polymorphism by microfluidic transient incomplete separation. Farzadfard A, Kunka A, Mason TO, Larsen JA, Norrild RK, Dominguez ET, Ray S, Buell AK. Chem Sci. 2024 Jan 8;15(7):2528-2544. doi: 10.1039/d3sc05371g. eCollection 2024 Feb 14. PubMed |
| Activation and Purification of ss-Glucocerebrosidase by Exploiting its Transporter LIMP-2 - Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease. Dobert JP, Bub S, Machtel R, Januliene D, Steger L, Regensburger M, Wilfling S, Chen JX, Dejung M, Plotz S, Hehr U, Moeller A, Arnold P, Zunke F. Adv Sci (Weinh). 2024 Jul;11(25):e2401641. doi: 10.1002/advs.202401641. Epub 2024 Apr 26. PubMed |
| Interplay between Copper, Phosphatidylserine, and alpha-Synuclein Suggests a Link between Copper Homeostasis and Synaptic Vesicle Cycling. Teng X, Stefaniak E, Willison KR, Ying L. ACS Chem Neurosci. 2024 Aug 7;15(15):2884-2896. doi: 10.1021/acschemneuro.4c00280. Epub 2024 Jul 16. PubMed |
| Astroglia proliferate upon the biogenesis of tunneling nanotubes via alpha-synuclein dependent transient nuclear translocation of focal adhesion kinase. Raghavan A, Kashyap R, Sreedevi P, Jos S, Chatterjee S, Alex A, D'Souza MN, Giridharan M, Muddashetty R, Manjithaya R, Padavattan S, Nath S. iScience. 2024 Jul 23;27(8):110565. doi: 10.1016/j.isci.2024.110565. eCollection 2024 Aug 16. PubMed |
| Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease. Eubanks E, VanderSleen K, Mody J, Patel N, Sacks B, Farahani MD, Wang J, Elliott J, Jaber N, Akcimen F, Bandres-Ciga S, Helweh F, Liu J, Archakam S, Kimelman R, Sharma B, Socha P, Guntur A, Bartels T, Dettmer U, Mouradian MM, Bahrami AH, Dai W, Baum J, Shi Z, Hardy J, Kara E. bioRxiv [Preprint]. 2024 Sep 1:2024.08.30.610195. doi: 10.1101/2024.08.30.610195. PubMed |
| Recursive seed amplification detects distinct alpha-synuclein strains in cerebrospinal fluid of patients with Parkinson's disease. Brauer S, Schniewind I, Dinter E, Falkenburger BH. Acta Neuropathol Commun. 2025 Jan 20;13(1):13. doi: 10.1186/s40478-024-01923-8. PubMed |
| Molecular Rotors Detect the Formation and Conversion of alpha-Synuclein Oligomers. Allerton SC, Kuimova MK, Aprile FA. ACS Appl Mater Interfaces. 2025 Feb 19;17(7):10499-10508. doi: 10.1021/acsami.4c21710. Epub 2025 Feb 5. PubMed |
| Live-cell quantification reveals viscoelastic regulation of synapsin condensates by alpha-synuclein. Wang H, Hoffmann C, Tromm JV, Su X, Elliott J, Wang H, Deng M, McClenaghan C, Baum J, Pang ZP, Milovanovic D, Shi Z. Sci Adv. 2025 Apr 18;11(16):eads7627. doi: 10.1126/sciadv.ads7627. Epub 2025 Apr 18. PubMed |
Defining essential charged residues in fibril formation of a lysosomal derived N-terminal alpha-synuclein truncation.
McGlinchey RP, Ramos S, Dimitriadis EK, Wilson CB, Lee JC.
Nat Commun. 2025 Apr 23;16(1):3825. doi: 10.1038/s41467-025-58899-9.
PubMed
Associated Plasmids |
| The basolateral amygdala and striatum propagate alpha-synuclein pathology causing increased fear response in a Parkinson's disease model. Lai TT, Xiang W, Stanojlovic M, Kaufer C, Feja M, Lau K, Zunke F, Richter F. Brain Behav Immun. 2025 Aug;128:469-486. doi: 10.1016/j.bbi.2025.04.025. Epub 2025 Apr 22. PubMed |
| Inhibition of cytotoxic fibril formation of alpha-synuclein and human insulin by Silymarin from the Silybum marianum. Moosakhani B, Taleb M, Mahmoudi Eshkaftaki Z, Nikfarjam N, Serajian A, Shahsavani MB, Meratan AA. PLoS One. 2025 May 2;20(5):e0320283. doi: 10.1371/journal.pone.0320283. eCollection 2025. PubMed |
| Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease. Eubanks E, VanderSleen K, Mody J, Patel N, Sacks B, Farahani MD, Wang J, Elliott J, Jaber N, Akcimen F, Bandres-Ciga S, Helweh F, Liu J, Archakam S, Kimelman R, Sharma B, Socha P, Guntur A, Huang Y, Ramalingam N, Guadagno E, Bartels T, Dettmer U, Mouradian MM, Bahrami AH, Dai W, Baum J, Shi Z, Hardy J, Kara E. Cell Rep. 2025 May 27;44(5):115636. doi: 10.1016/j.celrep.2025.115636. Epub 2025 May 1. PubMed |
| Photochemically synthesized gold nanoparticles conjugated with Boswellic acid inhibit alpha synuclein aggregation and delay fibrillation kinetics. Gharb M, Mozafari F, Arghavani P, Saboury AA, Riazi G. Sci Rep. 2025 Jul 17;15(1):25886. doi: 10.1038/s41598-025-11107-6. PubMed |
| Recombinant cathepsins B and L promote alpha-synuclein clearance and restore lysosomal function in human and murine models with alpha-synuclein pathology. Balta D, Varghese A, Prieto Huarcaya S, Di Spiezio A, Marques ARA, Akdas EY, Tabakacilar D, Drobny A, Werner C, Xiang W, Machtel R, Dobert JP, Fejtova A, Richter F, Kuspert M, Arnold P, Saftig P, Zunke F. Mol Neurodegener. 2025 Aug 29;20(1):95. doi: 10.1186/s13024-025-00886-1. PubMed |
| Proteolytic activities of extracellular vesicles attenuate A-synuclein aggregation. Vekrellis K, Lamprokostopoulou A, Melachroinou K, Kokoli M, Zingkou E, Skarveli M, Kolianou A, Samiotaki M, Sotiropoulou G. NPJ Parkinsons Dis. 2025 Sep 29;11(1):277. doi: 10.1038/s41531-025-01122-9. PubMed |
| Rotenone accelerates endogenous alpha-synuclein spreading and enhances neurodegeneration in an intra-striatal alpha-synuclein preformed fibril injected mouse model of Parkinson's disease. Khan E, Radwan N, Ardah MT, Kitada T, Haque ME. Front Cell Neurosci. 2025 Oct 3;19:1624593. doi: 10.3389/fncel.2025.1624593. eCollection 2025. PubMed |
| Thermodynamic stability modulates chaperone-mediated disaggregation of alpha-synuclein fibrils. Fricke C, Kunka A, Norrild RK, Wang S, Dang TL, Folke J, Shahnawaz M, Soto C, Aznar S, Wentink AS, Bukau B, Buell AK. Chem Sci. 2025 Nov 11;17(1):283-298. doi: 10.1039/d5sc04927j. eCollection 2026 Jan 7. PubMed |
If you have published an article using this material, please email us at [email protected] to have your article added to this page.