pEGFP-parkin WT Citations (31)

Originally described in: Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation.
Trempe JF, Sauve V, Grenier K, Seirafi M, Tang MY, Menade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K Science. 2013 May 9. PubMed Journal

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Articles Citing pEGFP-parkin WT

Articles
PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Panda PK, Naik PP, Meher BR, Das DN, Mukhopadhyay S, Praharaj PP, Maiti TK, Bhutia SK. Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):480-495. doi: 10.1016/j.bbamcr.2017.12.002. Epub 2017 Dec 8. PubMed
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL. Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11. PubMed
HIF-1alpha promotes autophagic proteolysis of Dicer and enhances tumor metastasis. Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. J Clin Invest. 2018 Feb 1;128(2):625-643. doi: 10.1172/JCI89212. Epub 2017 Dec 18. PubMed
Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria. Kruppa AJ, Kishi-Itakura C, Masters TA, Rorbach JE, Grice GL, Kendrick-Jones J, Nathan JA, Minczuk M, Buss F. Dev Cell. 2018 Feb 26;44(4):484-499.e6. doi: 10.1016/j.devcel.2018.01.007. Epub 2018 Feb 1. PubMed
Degradation of altered mitochondria by autophagy is impaired in Lafora disease. Lahuerta M, Aguado C, Sanchez-Martin P, Sanz P, Knecht E. FEBS J. 2018 Jun;285(11):2071-2090. doi: 10.1111/febs.14468. Epub 2018 Apr 23. PubMed
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson's disease. Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F. Cell Death Dis. 2018 Jun 13;9(6):700. doi: 10.1038/s41419-018-0722-7. PubMed
Parkinson's disease-linked Parkin mutations impair glutamatergic signaling in hippocampal neurons. Zhu M, Cortese GP, Waites CL. BMC Biol. 2018 Sep 10;16(1):100. doi: 10.1186/s12915-018-0567-7. PubMed
Disease-associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria. Cummins N, Tweedie A, Zuryn S, Bertran-Gonzalez J, Gotz J. EMBO J. 2019 Feb 1;38(3). pii: embj.201899360. doi: 10.15252/embj.201899360. Epub 2018 Dec 11. PubMed
Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance System. Cho HM, Ryu JR, Jo Y, Seo TW, Choi YN, Kim JH, Chung JM, Cho B, Kang HC, Yu SW, Yoo SJ, Kim H, Sun W. Mol Cell. 2019 Jan 17;73(2):364-376.e8. doi: 10.1016/j.molcel.2018.11.009. Epub 2018 Dec 20. PubMed
The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson's disease. Yi W, MacDougall EJ, Tang MY, Krahn AI, Gan-Or Z, Trempe JF, Fon EA. Hum Mol Genet. 2019 Sep 1;28(17):2811-2825. doi: 10.1093/hmg/ddz080. PubMed
Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux. Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS. Cells. 2019 Aug 14;8(8). pii: cells8080894. doi: 10.3390/cells8080894. PubMed
PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2. Chen H, Li Y, Li Y, Chen Z, Xie L, Li W, Zhu Y, Xue H, Koeffler HP, Wu W, Hu K, Yin D. Theranostics. 2020 Aug 8;10(22):9984-10000. doi: 10.7150/thno.47044. eCollection 2020. PubMed
Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy. Roverato ND, Sailer C, Catone N, Aichem A, Stengel F, Groettrup M. Cell Rep. 2021 Mar 16;34(11):108857. doi: 10.1016/j.celrep.2021.108857. PubMed
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of alpha-synuclein. Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, D'Sa K, Reynolds RH, Botia JA, Losa M, Lysenko V, Carta M, Heinzer D, Avar M, Chincisan A, Blauwendraat C, Garcia-Ruiz S, Pease D, Mottier L, Carrella A, Beck-Schneider D, Magalhaes AD, Aemisegger C, Theocharides APA, Fan Z, Marks JD, Hopp SC, Abramov AY, Lewis PA, Ryten M, Hardy J, Hyman BT, Aguzzi A. Cell Rep. 2021 Jun 8;35(10):109189. doi: 10.1016/j.celrep.2021.109189. PubMed
Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy. Ma KY, Fokkens MR, Reggiori F, Mari M, Verbeek DS. Transl Neurodegener. 2021 Jun 15;10(1):19. doi: 10.1186/s40035-021-00243-4. PubMed
Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models. Rouland L, Duplan E, Ramos Dos Santos L, Bernardin A, Katula KS, Manfioletti G, Idbaih A, Checler F, Alves da Costa C. Theranostics. 2021 Nov 1;11(20):10047-10063. doi: 10.7150/thno.57549. eCollection 2021. PubMed
Systematic analysis of PINK1 variants of unknown significance shows intact mitophagy function for most variants. Ma KY, Fokkens MR, van Laar T, Verbeek DS. NPJ Parkinsons Dis. 2021 Dec 10;7(1):113. doi: 10.1038/s41531-021-00258-8. PubMed
Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase. Shlevkov E, Murugan P, Montagna D, Stefan E, Hadzipasic A, Harvey JS, Kumar PR, Entova S, Bansal N, Bickford S, Wong LY, Hirst WD, Weihofen A, Silvian LF. iScience. 2021 Dec 18;25(1):103650. doi: 10.1016/j.isci.2021.103650. eCollection 2022 Jan 21. PubMed
PARK2 regulates eIF4B-driven lymphomagenesis. Kapadia BB, Roychowdhury A, Kayastha F, Nanaji N, Gartenhaus RB. Mol Cancer Res. 2022 Feb 1. pii: 681718. doi: 10.1158/1541-7786.MCR-21-0729. PubMed
Structural basis for feedforward control in the PINK1/Parkin pathway. Sauve V, Sung G, MacDougall EJ, Kozlov G, Saran A, Fakih R, Fon EA, Gehring K. EMBO J. 2022 Jun 14;41(12):e109460. doi: 10.15252/embj.2021109460. Epub 2022 May 2. PubMed
DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism. Pernaute B, Perez-Montero S, Sanchez Nieto JM, Di Gregorio A, Lima A, Lawlor K, Bowling S, Liccardi G, Tomas A, Meier P, Sesaki H, Rutter GA, Barbaric I, Rodriguez TA. Dev Cell. 2022 Jun 6;57(11):1316-1330.e7. doi: 10.1016/j.devcel.2022.04.020. Epub 2022 May 20. PubMed
PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells. Li Y, Chen H, Xie X, Yang B, Wang X, Zhang J, Qiao T, Guan J, Qiu Y, Huang YX, Tian D, Yao X, Lu D, Koeffler HP, Zhang Y, Yin D. Cancer Res. 2023 Feb 3;83(3):398-413. doi: 10.1158/0008-5472.CAN-22-2370. PubMed
Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease. Tang W, Thundyil J, Lim GGY, Tng TJW, Yeow SQZ, Nair A, Chai C, Yao TP, Lim KL. Hum Mol Genet. 2023 Apr 20;32(9):1466-1482. doi: 10.1093/hmg/ddac297. PubMed
PHLPP1 regulates PINK1-parkin signalling and life span. Chandra K, Swathi M, Keerthana B, Gopan S, Ghantasala JP, Joshi MB, Thondamal M, Parsa KVL. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166718. doi: 10.1016/j.bbadis.2023.166718. Epub 2023 Apr 13. PubMed
The inner mitochondrial membrane fission protein MTP18 serves as a mitophagy receptor to prevent apoptosis in oral cancer. Panigrahi DP, Praharaj PP, Behera BP, Patra S, Patil S, Patro BS, Bhutia SK. J Cell Sci. 2023 Jul 1;136(13):jcs259986. doi: 10.1242/jcs.259986. Epub 2023 Jul 11. PubMed
Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson's disease. Peng W, Schroder LF, Song P, Wong YC, Krainc D. Sci Adv. 2023 Jul 21;9(29):eadh3347. doi: 10.1126/sciadv.adh3347. Epub 2023 Jul 19. PubMed
Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma. Mishra SR, Behera BP, Singh VK, Mahapatra KK, Mundkinajeddu D, Bhat D, Minz AM, Sethi G, Efferth T, Das S, Bhutia SK. Phytomedicine. 2024 Jan;123:155157. doi: 10.1016/j.phymed.2023.155157. Epub 2023 Oct 21. PubMed
Lysosomes drive the piecemeal removal of mitochondrial inner membrane. Prashar A, Bussi C, Fearns A, Capurro MI, Gao X, Sesaki H, Gutierrez MG, Jones NL. Nature. 2024 Aug;632(8027):1110-1117. doi: 10.1038/s41586-024-07835-w. Epub 2024 Aug 21. PubMed
Induced Mitophagy Promotes Cell Cycle Re-Entry in Adult Cardiomyocytes. Ahmed RPH, Kanisicak O, Alam P. Cells. 2025 Jun 6;14(12):853. doi: 10.3390/cells14120853. PubMed
Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity. Yeon M, Perego M, Elokely KM, Abou-Gharbia M, Childers WE, Milcarek AT, Bertolini I, Tang HY, Languino LR, Stein GS, Ghule PN, Vietje BP, Taatjes DT, Altieri DC. Cancer Res. 2025 Dec 15;85(24):5033-5048. doi: 10.1158/0008-5472.CAN-25-0904. PubMed
Mutations in the Key Autophagy Tethering Factor EPG5 Link Neurodevelopmental and Neurodegenerative Disorders Including Early-Onset Parkinsonism. Dafsari HS, Deneubourg C, Singh K, Maroofian R, Suprenant Z, Kho AL, Ingham NJ, Steel KP, Sheshadri P, Baur F, Hentrich L, Gerisch B, Zamani M, Alves C, Siddiqui A, Dafsari HS, Salari M, Lang AE, Harris M, Abdelaleem A, Sadeghian S, Azizimalamiri R, Galehdari H, Shariati G, Sedaghat A, Zeighami J, Calame D, Marafi D, Duan R, Boehnke A, Clark GD, Rosenfeld JA, Mohila CA, Steel D, Chopra S, Sharma S, Kohlschmidt N, Patzer S, Saffari A, Ebrahimi-Fakhari D, Cavdartepe BE, Chang IJ, Beckman E, Peters R, Fennell AP, Lo B, Averdunk L, Distelmaier F, Baethmann M, Elmslie F, Joost K, Nampoothiri S, Yesodharan D, Mandel H, Kimball A, Kline AD, Mignot C, Keren B, Laugel V, Ounap K, Devadathan K, van Berkestijn FMC, Silwal A, Koene S, Verma S, Karim MY, Boubidi C, Aziz M, ElGhazali G, Mattas L, Miryounesi M, Hashemi-Gorji F, Alavi S, Nouri N, Noruzinia M, Kavousi S, Kamath A, Jayawant S, Saneto R, Haridy NA, Kart PO, Cansu A, Joubert M, Beneteau C, Stuurman KE, Wilke M, Barakat TS, Tajsharghi H, Scardamaglia A, Vallian S, Hiz S, Shoeibi A, Boostani R, Hashemi N, Babaei M, Alsaleh NS, Porter J, Attie-Bitach T, Marzin P, Wicher D, Gold JI, Schuler E, Kashgari A, Alanazi RF, Eyaid W, Engelen M, Langeveld M, Stuve B, Li Y, Yigit G, Wollnik B, Monje MHG, Krainc D, Mencacci NE, Bakhtiari S, Kruer M, Argilli E, Sherr E, Jamshidi Y, Karimiani EG, Cheung YWS, Karin I, Zifarelli G, Bauer P, Chung WK, Lupski JR, Kurian MA, Dotsch J, von Kleist-Retzow JC, Klopstock T, Wagner M, Yip C, Roos A, Carsetti R, Dionisi-Vici C, Gautel M, Duchen MR, Antebi A, Houlden H, Fanto M, Jungbluth H. Ann Neurol. 2025 Nov;98(5):932-950. doi: 10.1002/ana.78013. Epub 2025 Oct 6. PubMed

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