pMRX-IP-GFP-LC3-RFP-LC3ΔG Citations (37)
Originally described in: An Autophagic Flux Probe that Releases an Internal Control.Kaizuka T, Morishita H, Hama Y, Tsukamoto S, Matsui T, Toyota Y, Kodama A, Ishihara T, Mizushima T, Mizushima N Mol Cell. 2016 Nov 17;64(4):835-849. doi: 10.1016/j.molcel.2016.09.037. Epub 2016 Nov 3. PubMed Journal
Articles Citing pMRX-IP-GFP-LC3-RFP-LC3ΔG
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| DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy. Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA. Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003. PubMed |
| Monitoring autophagic flux using p62/SQSTM1 based luciferase reporters in glioma cells. Min Z, Ting Y, Mingtao G, Xiaofei T, Dong Y, Chenguang Z, Wei D. Exp Cell Res. 2018 Feb 1;363(1):84-94. doi: 10.1016/j.yexcr.2017.12.027. Epub 2017 Dec 28. PubMed |
| Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, van Wijk SJL, Kogel D, Fulda S. Cell Death Dis. 2018 Sep 24;9(10):994. doi: 10.1038/s41419-018-1003-1. PubMed |
| STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes. Martin AP, Jacquemyn M, Lipecka J, Chhuon C, Aushev VN, Meunier B, Singh MK, Carpi N, Piel M, Codogno P, Hergovich A, Parrini MC, Zalcman G, Guerrera IC, Daelemans D, Camonis JH. EMBO Rep. 2019 Nov 5;20(11):e48150. doi: 10.15252/embr.201948150. Epub 2019 Sep 23. PubMed |
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Lim CY, Davis OB, Shin HR, Zhang J, Berdan CA, Jiang X, Counihan JL, Ory DS, Nomura DK, Zoncu R.
Nat Cell Biol. 2019 Oct;21(10):1206-1218. doi: 10.1038/s41556-019-0391-5. Epub 2019 Sep 23.
PubMed
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| Mitochondrial-specific autophagy linked to mitochondrial dysfunction following traumatic freeze injury in mice. Nichenko AS, Southern WM, Tehrani KF, Qualls AE, Flemington AB, Mercer GH, Yin A, Mortensen LJ, Yin H, Call JA. Am J Physiol Cell Physiol. 2020 Feb 1;318(2):C242-C252. doi: 10.1152/ajpcell.00123.2019. Epub 2019 Nov 13. PubMed |
| Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis. Cui W, Sathyanarayan A, Lopresti M, Aghajan M, Chen C, Mashek DG. Autophagy. 2020 Feb 19:1-16. doi: 10.1080/15548627.2020.1728097. PubMed |
| C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis. Wang M, Wang H, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G, Ying Z. Aging Cell. 2020 Apr;19(4):e13126. doi: 10.1111/acel.13126. Epub 2020 Feb 25. PubMed |
| Microtubule disrupting agent-mediated inhibition of cancer cell growth is associated with blockade of autophagic flux and simultaneous induction of apoptosis. Hasanain M, Sahai R, Pandey P, Maheshwari M, Choyal K, Gandhi D, Singh A, Singh K, Mitra K, Datta D, Sarkar J. Cell Prolif. 2020 Apr;53(4):e12749. doi: 10.1111/cpr.12749. Epub 2020 Mar 13. PubMed |
| Prodigiosin impairs autophagosome-lysosome fusion that sensitizes colorectal cancer cells to 5-fluorouracil-induced cell death. Zhao C, Qiu S, He J, Peng Y, Xu H, Feng Z, Huang H, Du Y, Zhou Y, Nie Y. Cancer Lett. 2020 Jul 1;481:15-23. doi: 10.1016/j.canlet.2020.03.010. Epub 2020 Mar 14. PubMed |
| Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy. Chen Y, Wang H, Ying Z, Gao Q. Biochem Biophys Res Commun. 2020 May 21;526(1):231-238. doi: 10.1016/j.bbrc.2020.03.051. Epub 2020 Mar 21. PubMed |
| Autophagy: an essential but limited cellular process for timely skeletal muscle recovery from injury. Call JA, Nichenko AS. Autophagy. 2020 Jul;16(7):1344-1347. doi: 10.1080/15548627.2020.1753000. Epub 2020 Apr 17. PubMed |
| 1-phenyl 2-thiourea (PTU) activates autophagy in zebrafish embryos. Chen XK, Kwan JS, Chang RC, Ma AC. Autophagy. 2020 Apr 22:1-10. doi: 10.1080/15548627.2020.1755119. PubMed |
| MicroRNA-381 facilitates autophagy and apoptosis in prostate cancer cells via inhibiting the RELN-mediated PI3K/AKT/mTOR signaling pathway. Liao W, Zhang Y. Life Sci. 2020 Aug 1;254:117672. doi: 10.1016/j.lfs.2020.117672. Epub 2020 Apr 15. PubMed |
| Regulation of autophagy in leukocytes through RNA N(6)-adenosine methylation in chronic kidney disease patients. Wang CY, Lin TA, Ho MY, Yeh JK, Tsai ML, Hung KC, Hsieh IC, Wen MS. Biochem Biophys Res Commun. 2020 Jul 5;527(4):953-959. doi: 10.1016/j.bbrc.2020.04.138. Epub 2020 May 18. PubMed |
| beta-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest. Zhang R, Pan T, Xiang Y, Zhang M, Feng J, Liu S, Duan T, Chen P, Zhai B, Chen X, Wang W, Chen B, Han X, Chen L, Yan L, Jin T, Liu Y, Li G, Huang X, Zhang W, Sun Y, Li Q, Zhang Q, Zhuo L, Xie T, Wu Q, Sui X. Front Bioeng Biotechnol. 2020 May 8;8:378. doi: 10.3389/fbioe.2020.00378. eCollection 2020. PubMed |
| TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity. Wang CY, Chen CC, Lin MH, Su HT, Ho MY, Yeh JK, Tsai ML, Hsieh IC, Wen MS. Biology (Basel). 2020 Oct 29;9(11). pii: biology9110369. doi: 10.3390/biology9110369. PubMed |
| Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes. Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, Roche PA, Cattral MS, Gaisano HY. Autophagy. 2021 Oct;17(10):3068-3081. doi: 10.1080/15548627.2020.1852725. Epub 2020 Dec 7. PubMed |
| Cathepsin B is a mediator of organelle-specific initiation of ferroptosis. Kuang F, Liu J, Li C, Kang R, Tang D. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1464-1469. doi: 10.1016/j.bbrc.2020.10.035. Epub 2020 Oct 22. PubMed |
| Lifelong Ulk1-Mediated Autophagy Deficiency in Muscle Induces Mitochondrial Dysfunction and Contractile Weakness. Nichenko AS, Sorensen JR, Southern WM, Qualls AE, Schifino AG, McFaline-Figueroa J, Blum JE, Tehrani KF, Yin H, Mortensen LJ, Thalacker-Mercer AE, Greising SM, Call JA. Int J Mol Sci. 2021 Feb 16;22(4). pii: ijms22041937. doi: 10.3390/ijms22041937. PubMed |
| The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore. Chang HC, Tao RN, Tan CT, Wu YJ, Bay BH, Yu VC. Autophagy. 2021 Nov;17(11):3725-3739. doi: 10.1080/15548627.2021.1896157. Epub 2021 Mar 30. PubMed |
| Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling. Huynh DTN, Jin Y, Myung CS, Heo KS. Cancers (Basel). 2021 Apr 15;13(8). pii: cancers13081892. doi: 10.3390/cancers13081892. PubMed |
| High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol. Deitersen J, Berning L, Stuhldreier F, Ceccacci S, Schlutermann D, Friedrich A, Wu W, Sun Y, Bohler P, Berleth N, Mendiburo MJ, Seggewiss S, Anand R, Reichert AS, Monti MC, Proksch P, Stork B. Cell Death Dis. 2021 May 31;12(6):560. doi: 10.1038/s41419-021-03830-5. PubMed |
| Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury. Liu Q, Wu J, Zhang X, Li X, Wu X, Zhao Y, Ren J. Cell Death Dis. 2021 Jul 3;12(7):673. doi: 10.1038/s41419-021-03961-9. PubMed |
| Galphaq activation modulates autophagy by promoting mTORC1 signaling. Cabezudo S, Sanz-Flores M, Caballero A, Tasset I, Rebollo E, Diaz A, Aragay AM, Cuervo AM, Mayor F Jr, Ribas C. Nat Commun. 2021 Jul 27;12(1):4540. doi: 10.1038/s41467-021-24811-4. PubMed |
| Autophagic flux in cancer cells at the invasive front in the tumor-stroma border. Yan F, Zhang X, Tan R, Li M, Xiao Z, Wang H, Zhang Z, Ma Z, Liu Z. Aging (Albany NY). 2021 Aug 17;13(16):20229-20245. doi: 10.18632/aging.203406. Epub 2021 Aug 17. PubMed |
| Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy. Shyam R, Ogando DG, Choi M, Liton PB, Bonanno JA. Invest Ophthalmol Vis Sci. 2021 Sep 2;62(12):15. doi: 10.1167/iovs.62.12.15. PubMed |
| Autophagy Inhibition by Targeting PIKfyve Potentiates Response to Immune Checkpoint Blockade in Prostate Cancer. Qiao Y, Choi JE, Tien JC, Simko SA, Rajendiran T, Vo JN, Delekta AD, Wang L, Xiao L, Hodge NB, Desai P, Mendoza S, Juckette K, Xu A, Soni T, Su F, Wang R, Cao X, Yu J, Kryczek I, Wang XM, Wang X, Siddiqui J, Wang Z, Bernard A, Fernandez-Salas E, Navone NM, Ellison SJ, Ding K, Eskelinen EL, Heath EI, Klionsky DJ, Zou W, Chinnaiyan AM. Nat Cancer. 2021 Sep;2:978-993. doi: 10.1038/s43018-021-00237-1. Epub 2021 Aug 2. PubMed |
| STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death. Remy J, Linder B, Weirauch U, Day BW, Stringer BW, Herold-Mende C, Aigner A, Krohn K, Kogel D. Cancers (Basel). 2022 Jan 11;14(2). pii: cancers14020339. doi: 10.3390/cancers14020339. PubMed |
| In vivo CRISPR screens reveal a HIF-1alpha-mTOR-network regulates T follicular helper versus Th1 cells. Huang B, Phelan JD, Preite S, Gomez-Rodriguez J, Johansen KH, Shibata H, Shaffer AL 3rd, Xu Q, Jeffrey B, Kirby M, Anderson S, Yang Y, Gossa S, McGavern DB, Staudt LM, Schwartzberg PL. Nat Commun. 2022 Feb 10;13(1):805. doi: 10.1038/s41467-022-28378-6. PubMed |
| Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing. Frey N, Tortola L, Egli D, Janjuha S, Rothgangl T, Marquart KF, Ampenberger F, Kopf M, Schwank G. Nat Commun. 2022 Apr 4;13(1):1804. doi: 10.1038/s41467-022-29412-3. PubMed |
| Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD. Gupta U, Ghosh S, Wallace CT, Shang P, Xin Y, Nair AP, Yazdankhah M, Strizhakova A, Ross MA, Liu H, Hose S, Stepicheva NA, Chowdhury O, Nemani M, Maddipatla V, Grebe R, Das M, Lathrop KL, Sahel JA, Zigler JS Jr, Qian J, Ghosh A, Sergeev Y, Handa JT, St Croix CM, Sinha D. Autophagy. 2023 Jan;19(1):92-111. doi: 10.1080/15548627.2022.2062887. Epub 2022 Apr 26. PubMed |
| Induction of autophagy-dependent ferroptosis to eliminate drug-tolerant human retinoblastoma cells. Liu K, Huang J, Liu J, Klionsky DJ, Kang R, Tang D. Cell Death Dis. 2022 Jun 2;13(6):521. doi: 10.1038/s41419-022-04974-8. PubMed |
| TMEM164 is a new determinant of autophagy-dependent ferroptosis. Liu J, Liu Y, Wang Y, Li C, Xie Y, Klionsky DJ, Kang R, Tang D. Autophagy. 2023 Mar;19(3):945-956. doi: 10.1080/15548627.2022.2111635. Epub 2022 Aug 22. PubMed |
| Cytoskeletal vimentin regulates cell size and autophagy through mTORC1 signaling. Mohanasundaram P, Coelho-Rato LS, Modi MK, Urbanska M, Lautenschlager F, Cheng F, Eriksson JE. PLoS Biol. 2022 Sep 13;20(9):e3001737. doi: 10.1371/journal.pbio.3001737. eCollection 2022 Sep. PubMed |
| Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology. Liao EE, Yang M, Nathan Kochen N, Vunnam N, Braun AR, Ferguson DM, Sachs JN. Mol Neurobiol. 2023 Oct;60(10):6133-6144. doi: 10.1007/s12035-023-03417-5. Epub 2023 Jul 10. PubMed |
| Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors. Mariner BL, Rodriguez AS, Heath OC, McCormick MA. Geroscience. 2024 Apr;46(2):1755-1773. doi: 10.1007/s11357-023-00938-8. Epub 2023 Sep 25. PubMed |
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