pLV-EF1a-IRES-Blast Citations (54)
Originally described in: Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.Hayer A, Shao L, Chung M, Joubert LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T Nat Cell Biol. 2016 Dec;18(12):1311-1323. doi: 10.1038/ncb3438. Epub 2016 Nov 14. PubMed Journal
Articles Citing pLV-EF1a-IRES-Blast
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| Barrier-to-Autointegration Factor 1 Protects against a Basal cGAS-STING Response. Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum AK, Zhang R, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS. mBio. 2020 Mar 10;11(2). pii: mBio.00136-20. doi: 10.1128/mBio.00136-20. PubMed |
| Filoviruses Use the HOPS Complex and UVRAG To Traffic to Niemann-Pick C1 Compartments during Viral Entry. Bo Y, Qiu S, Mulloy RP, Cote M. J Virol. 2020 Jul 30;94(16). pii: JVI.01002-20. doi: 10.1128/JVI.01002-20. Print 2020 Jul 30. PubMed |
| Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunotherapy. Iyer S, Zhang S, Yucel S, Horn H, Smith SG, Reinhardt F, Hoefsmit E, Assatova B, Casado J, Meinsohn MC, Barrasa MI, Bell GW, Perez-Villatoro F, Huhtinen K, Hynninen J, Oikkonen J, Galhenage PM, Pathania S, Hammond PT, Neel BG, Farkkila A, Pepin D, Weinberg RA. Cancer Discov. 2021 Feb;11(2):384-407. doi: 10.1158/2159-8290.CD-20-0818. Epub 2020 Nov 6. PubMed |
| m(6) A deposition is regulated by PRMT1-mediated arginine methylation of METTL14 in its disordered C-terminal region. Wang Z, Pan Z, Adhikari S, Harada BT, Shen L, Yuan W, Abeywardana T, Al-Hadid Q, Stark JM, He C, Lin L, Yang Y. EMBO J. 2021 Mar 1;40(5):e106309. doi: 10.15252/embj.2020106309. Epub 2021 Jan 18. PubMed |
| A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry. Zhu Y, Feng F, Hu G, Wang Y, Yu Y, Zhu Y, Xu W, Cai X, Sun Z, Han W, Ye R, Qu D, Ding Q, Huang X, Chen H, Xu W, Xie Y, Cai Q, Yuan Z, Zhang R. Nat Commun. 2021 Feb 11;12(1):961. doi: 10.1038/s41467-021-21213-4. PubMed |
| Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Wang Y, Liu S, Yang Z, Algazi AP, Lomeli SH, Wang Y, Othus M, Hong A, Wang X, Randolph CE, Jones AM, Bosenberg MW, Byrum SD, Tackett AJ, Lopez H, Yates C, Solit DB, Ribas A, Piva M, Moriceau G, Lo RS. Cancer Cell. 2021 Oct 11;39(10):1375-1387.e6. doi: 10.1016/j.ccell.2021.07.023. Epub 2021 Aug 19. PubMed |
| Methodological Development of a Multi-Readout Assay for the Assessment of Antiviral Drugs against SARS-CoV-2. Hahn F, Hage S, Herrmann A, Wangen C, Kicuntod J, Jungnickl D, Tillmanns J, Muller R, Fraedrich K, Uberla K, Kohlhof H, Ensser A, Marschall M. Pathogens. 2021 Aug 25;10(9). pii: pathogens10091076. doi: 10.3390/pathogens10091076. PubMed |
| A prenylated dsRNA sensor protects against severe COVID-19. Wickenhagen A, Sugrue E, Lytras S, Kuchi S, Noerenberg M, Turnbull ML, Loney C, Herder V, Allan J, Jarmson I, Cameron-Ruiz N, Varjak M, Pinto RM, Lee JY, Iselin L, Palmalux N, Stewart DG, Swingler S, Greenwood EJD, Crozier TWM, Gu Q, Davies EL, Clohisey S, Wang B, Trindade Maranhao Costa F, Freire Santana M, de Lima Ferreira LC, Murphy L, Fawkes A, Meynert A, Grimes G, Da Silva Filho JL, Marti M, Hughes J, Stanton RJ, Wang ECY, Ho A, Davis I, Jarrett RF, Castello A, Robertson DL, Semple MG, Openshaw PJM, Palmarini M, Lehner PJ, Baillie JK, Rihn SJ, Wilson SJ. Science. 2021 Oct 29;374(6567):eabj3624. doi: 10.1126/science.abj3624. Epub 2021 Oct 29. PubMed |
| Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination. Herrmann A, Jungnickl D, Cordsmeier A, Peter AS, Uberla K, Ensser A. Int J Mol Sci. 2021 Sep 22;22(19). pii: ijms221910188. doi: 10.3390/ijms221910188. PubMed |
| Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Mahlokozera T, Patel B, Chen H, Desouza P, Qu X, Mao DD, Hafez D, Yang W, Taiwo R, Paturu M, Salehi A, Gujar AD, Dunn GP, Mosammaparast N, Petti AA, Yano H, Kim AH. Nat Commun. 2021 Nov 3;12(1):6321. doi: 10.1038/s41467-021-26653-6. PubMed |
| Spike residue 403 affects binding of coronavirus spikes to human ACE2. Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Muller JA, Kruger J, Heller S, Stenger S, Hoffmann M, Pohlmann S, Kleger A, Jacob T, Conzelmann KK, Ensser A, Sparrer KMJ, Kirchhoff F. Nat Commun. 2021 Nov 25;12(1):6855. doi: 10.1038/s41467-021-27180-0. PubMed |
| AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. Lin Y, Huang C, Gao H, Li X, Lin Q, Zhou S, Huo Z, Huang Y, Liu C, Zhang P. J Cell Sci. 2022 Jan 1;135(1). pii: 273618. doi: 10.1242/jcs.258910. Epub 2022 Jan 7. PubMed |
| Kaposi's sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis. Chen W, Ding Y, Liu D, Lu Z, Wang Y, Yuan Y. PLoS Pathog. 2021 Dec 22;17(12):e1009600. doi: 10.1371/journal.ppat.1009600. eCollection 2021 Dec. PubMed |
| TGF-beta-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures. Chaurio RA, Anadon CM, Lee Costich T, Payne KK, Biswas S, Harro CM, Moran C, Ortiz AC, Cortina C, Rigolizzo KE, Sprenger KB, Mine JA, Innamarato P, Mandal G, Powers JJ, Martin A, Wang Z, Mehta S, Perez BA, Li R, Robinson J, Kroeger JL, Curiel TJ, Yu X, Rodriguez PC, Conejo-Garcia JR. Immunity. 2022 Jan 11;55(1):115-128.e9. doi: 10.1016/j.immuni.2021.12.007. PubMed |
| Targeting S100A9-ALDH1A1-Retinoic Acid Signaling to Suppress Brain Relapse in EGFR-Mutant Lung Cancer. Biswas AK, Han S, Tai Y, Ma W, Coker C, Quinn SA, Shakri AR, Zhong TJ, Scholze H, Lagos GG, Mela A, Manova-Todorova K, de Stanchina E, Ferrando AA, Mendelsohn C, Canoll P, Yu HA, Paik PK, Saqi A, Shu CA, Kris MG, Massague J, Acharyya S. Cancer Discov. 2022 Apr 1;12(4):1002-1021. doi: 10.1158/2159-8290.CD-21-0910. PubMed |
| Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Anadon CM, Yu X, Hanggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Cancer Cell. 2022 May 9;40(5):545-557.e13. doi: 10.1016/j.ccell.2022.03.008. Epub 2022 Apr 14. PubMed |
| LINC00152 Drives a Competing Endogenous RNA Network in Human Hepatocellular Carcinoma. Pellegrino R, Castoldi M, Ticconi F, Skawran B, Budczies J, Rose F, Schwab C, Breuhahn K, Neumann UP, Gaisa NT, Loosen SH, Luedde T, Costa IG, Longerich T. Cells. 2022 May 3;11(9). pii: cells11091528. doi: 10.3390/cells11091528. PubMed |
Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability.
Unlu G, Prizer B, Erdal R, Yeh HW, Bayraktar EC, Birsoy K.
Mol Cell. 2022 Aug 4;82(15):2832-2843.e7. doi: 10.1016/j.molcel.2022.05.024. Epub 2022 Jun 16.
PubMed
Associated Plasmids |
| Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins. Fessenden TB, Stopfer LE, Chatterjee F, Zulueta J, Mesfin J, Cordero Dumit T, Reijers I, Hoefsmit EP, Blank C, White F, Spranger S. J Immunother Cancer. 2022 Jul;10(7):e004159. doi: 10.1136/jitc-2021-004159. PubMed |
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
Ratto E, Chowdhury SR, Siefert NS, Schneider M, Wittmann M, Helm D, Palm W.
Nat Commun. 2022 Aug 17;13(1):4848. doi: 10.1038/s41467-022-32515-6.
PubMed
Associated Plasmids |
| De novo sphingolipid biosynthesis necessitates detoxification in cancer cells. Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, Zhu LJ, Greer PL, Quehenberger O, Torres EM, Kim D. Cell Rep. 2022 Sep 27;40(13):111415. doi: 10.1016/j.celrep.2022.111415. PubMed |
| Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis. Jun YW, Lee S, Ban BK, Lee JA, Gao FB. Autophagy. 2023 Jul;19(7):2045-2061. doi: 10.1080/15548627.2023.2169309. Epub 2023 Feb 27. PubMed |
| Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells. Cottrell KA, Ryu S, Torres LS, Schab AM, Weber JD. bioRxiv. 2023 Mar 1:2023.02.27.530307. doi: 10.1101/2023.02.27.530307. Preprint. PubMed |
| Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway. Park WY, Gray JM, Holewinski RJ, Andresson T, So JY, Carmona-Rivera C, Hollander MC, Yang HH, Lee M, Kaplan MJ, Cappell SD, Yang L. Nat Cancer. 2023 Mar;4(3):419-435. doi: 10.1038/s43018-023-00524-z. Epub 2023 Mar 27. PubMed |
| FET fusion oncoproteins disrupt physiologic DNA repair networks in cancer. Menon S, Breese MR, Lin YP, Allegakoen H, Perati S, Heslin A, Horlbeck MA, Weissman J, Sweet-Cordero EA, Bivona TG, Tulpule A. bioRxiv. 2023 May 16:2023.04.30.538578. doi: 10.1101/2023.04.30.538578. Preprint. PubMed |
| Redefining the role of AMPK in autophagy and the energy stress response. Park JM, Lee DH, Kim DH. Nat Commun. 2023 May 24;14(1):2994. doi: 10.1038/s41467-023-38401-z. PubMed |
| NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness. Folcher A, Gordienko D, Iamshanova O, Bokhobza A, Shapovalov G, Kannancheri-Puthooru D, Mariot P, Allart L, Desruelles E, Spriet C, Diez R, Oullier T, Marionneau-Lambot S, Brisson L, Geraci S, Impheng H, Lehen'kyi V, Haustrate A, Mihalache A, Gosset P, Chadet S, Retif S, Laube M, Sobilo J, Lerondel S, Villari G, Serini G, Pla AF, Roger S, Fromont-Hankard G, Djamgoz M, Clezardin P, Monteil A, Prevarskaya N. EMBO J. 2023 Jul 3;42(13):e112198. doi: 10.15252/embj.2022112198. Epub 2023 Jun 6. PubMed |
| FET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer. Tulpule A, Menon S, Breese M, Lin Y, Allegakoen H, Perati S, Heslin A, Horlbeck M, Weissman J, Sweet-Cordero A, Bivona T. Res Sq. 2023 May 29:rs.3.rs-2869150. doi: 10.21203/rs.3.rs-2869150/v1. Preprint. PubMed |
| PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection. Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, Mothes W, Karatekin E, Wilen CB, MacMicking JD. Nature. 2023 Jul;619(7971):819-827. doi: 10.1038/s41586-023-06322-y. Epub 2023 Jul 12. PubMed |
| MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis. Phadnis VV, Snider J, Varadharajan V, Ramachandiran I, Deik AA, Lai ZW, Kunchok T, Eaton EN, Sebastiany C, Lyakisheva A, Vaccaro KD, Allen J, Yao Z, Wong V, Geng B, Weiskopf K, Clish CB, Brown JM, Stagljar I, Weinberg RA, Henry WS. Cell Rep. 2023 Sep 26;42(9):113023. doi: 10.1016/j.celrep.2023.113023. Epub 2023 Sep 8. PubMed |
| Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Huang Y, Peng Q, Tian X, Chen C, Zhu X, Huang C, Huo Z, Liu Y, Yang C, Liu C, Zhang P. Nat Commun. 2024 Jan 5;15(1):296. doi: 10.1038/s41467-023-44580-6. PubMed |
| Repeat DNA methylation is modulated by adherens junction signaling. Brenner LM, Meyer F, Yang H, Kohler AR, Bashtrykov P, Guo M, Jeltsch A, Lungu C, Olayioye MA. Commun Biol. 2024 Mar 7;7(1):286. doi: 10.1038/s42003-024-05990-4. PubMed |
| Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells. Cottrell KA, Ryu S, Pierce JR, Soto Torres L, Bohlin HE, Schab AM, Weber JD. Cancer Res Commun. 2024 Apr 4;4(4):986-1003. doi: 10.1158/2767-9764.CRC-23-0488. PubMed |
| Evaluation of Bispecific T-Cell Engagers Targeting Murine Cytomegalovirus. Menschikowski H, Bednar C, Kubel S, Hermann M, Bauer L, Thomas M, Cordsmeier A, Ensser A. Viruses. 2024 May 29;16(6):869. doi: 10.3390/v16060869. PubMed |
| PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation. Tan CW, Sim DY, Zhen Y, Tian H, Koh J, Roca X. Nucleic Acids Res. 2024 Aug 27;52(15):8800-8814. doi: 10.1093/nar/gkae557. PubMed |
| FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer. Tai Y, Chow A, Han S, Coker C, Ma W, Gu Y, Estrada Navarro V, Kandpal M, Hibshoosh H, Kalinsky K, Manova-Todorova K, Safonov A, Walsh EM, Robson M, Norton L, Baer R, Merghoub T, Biswas AK, Acharyya S. EMBO Mol Med. 2024 Aug;16(8):1957-1980. doi: 10.1038/s44321-024-00094-2. Epub 2024 Jul 2. PubMed |
| The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway. Harada N, Asada S, Jiang L, Nguyen H, Moreau L, Marina RJ, Adelman K, Iyer DR, D'Andrea AD. Mol Cell. 2024 Jul 25;84(14):2618-2633.e10. doi: 10.1016/j.molcel.2024.06.031. Epub 2024 Jul 17. PubMed |
Excitable Rho dynamics control cell shape and motility by sequentially activating ERM proteins and actomyosin contractility.
Marshall-Burghardt S, Migueles-Ramirez RA, Lin Q, El Baba N, Saada R, Umar M, Mavalwala K, Hayer A.
Sci Adv. 2024 Sep 6;10(36):eadn6858. doi: 10.1126/sciadv.adn6858. Epub 2024 Sep 6.
PubMed
Associated Plasmids |
| Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis. Liu K, Gao Q, Jia Y, Wei J, Chaudhuri SM, Wang S, Tang A, Mani NL, Iyer R, Cheng Y, Gao B, Lu W, Sun Z, Zhang B, Liu H, Fang D. iScience. 2024 Jul 27;27(9):110592. doi: 10.1016/j.isci.2024.110592. eCollection 2024 Sep 20. PubMed |
| A TBK1-independent primordial function of STING in lysosomal biogenesis. Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX. Mol Cell. 2024 Oct 17;84(20):3979-3996.e9. doi: 10.1016/j.molcel.2024.08.026. Epub 2024 Sep 19. PubMed |
| Optogenetically engineered Septin-7 enhances immune cell infiltration of tumor spheroids. Chen J, Hnath B, Sha CM, Beidler L, Schell TD, Dokholyan NV. Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2405717121. doi: 10.1073/pnas.2405717121. Epub 2024 Oct 23. PubMed |
| Lung Cancer-Intrinsic SOX2 Expression Mediates Resistance to Checkpoint Blockade Therapy by Inducing Treg-Dependent CD8+ T-cell Exclusion. Torres-Mejia E, Weng S, Whittaker CA, Nguyen KB, Duong E, Yim L, Spranger S. Cancer Immunol Res. 2025 Apr 2;13(4):496-516. doi: 10.1158/2326-6066.CIR-24-0184. PubMed |
| Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity. Latorre-Muro P, Vitale T, Ravichandran M, Zhang K, Palozzi JM, Bennett CF, Lamas-Paz A, Sohn JH, Jackson TD, Jedrychowski M, Gygi SP, Kajimura S, Schmoker A, Jeon H, Eck MJ, Puigserver P. Nat Cell Biol. 2025 Jan;27(1):130-140. doi: 10.1038/s41556-024-01555-z. Epub 2025 Jan 3. PubMed |
| ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation. Poddar S, Chauvin SD, Archer CH, Qian W, Castillo-Badillo JA, Yin X, Disbennett WM, Miner CA, Holley JA, Naismith TV, Stinson WA, Wei X, Ning Y, Fu J, Ochoa TA, Surve N, Zaver SA, Wodzanowski KA, Balka KR, Venkatraman R, Liu C, Rome K, Bailis W, Shiba Y, Cherry S, Shin S, Semenkovich CF, De Nardo D, Yoh S, Roberson EDO, Chanda SK, Kast DJ, Miner JJ. Cell. 2025 Mar 20;188(6):1605-1622.e26. doi: 10.1016/j.cell.2025.01.027. Epub 2025 Feb 12. PubMed |
| Therapy enhancing chromosome instability may be advantageous for IDH1 (R132H/WT) gliomas. Goncharov NV, Baklanov IN, Gulaia VS, Shuliak AP, Lanskikh DV, Zhmenia VM, Shmelev ME, Shved NA, Wu J, Liskovykh M, Larionov V, Kouprina N, Kumeiko VV. NAR Cancer. 2025 Feb 13;7(1):zcaf003. doi: 10.1093/narcan/zcaf003. eCollection 2025 Mar. PubMed |
| Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis. Jonker PB, Sadullozoda M, Cognet G, Saab JJA, Sokol KH, Wu VX, Kumari D, Sheehan C, Ozgurses ME, Agovino D, Croley G, Patel SA, Bock-Hughes A, Macleod KF, Shah H, Coloff JL, Lien EC, Muir A. bioRxiv [Preprint]. 2025 Mar 13:2025.03.10.642426. doi: 10.1101/2025.03.10.642426. PubMed |
Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.
Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B.
Cancer Cell. 2025 Jun 9;43(6):1076-1092.e5. doi: 10.1016/j.ccell.2025.03.031. Epub 2025 Apr 10.
PubMed
Associated Plasmids |
| RNF138 regulates skeletal muscle differentiation via the Wnt/beta-catenin signaling pathway. Wang W, Wang Z, Li R, Huang W, Ling Q, Li X, Li Z, Cao M, Zhang Z, Sun Q, Liang Z, Zhang HA, Jiang X, Lin C, Chen Y, Zhao B, Zhao Y, Pan JA, Peng X. Theranostics. 2025 Mar 18;15(10):4446-4464. doi: 10.7150/thno.110925. eCollection 2025. PubMed |
| Disruption of Microhomology-mediated End-joining in Ewing Sarcoma. Asada S, Zhu G, Abeykoon JP, Tanaka Y, Nguyen H, Hirohashi Y, Iyer DR, Ashton NW, Mukkavalli S, Velazquez M, Jiang L, Busso MD, Thangaiah JJ, Robinson SI, Parmar K, Van Allen EM, Gillani R, Shapiro GI, D'Andrea AD. bioRxiv [Preprint]. 2025 Sep 18:2025.05.06.651696. doi: 10.1101/2025.05.06.651696. PubMed |
| Cyclin D1 overexpression induces replication stress and microhomology-mediated end-joining dependence in mantle cell lymphoma. Abeykoon JP, Asada S, Zhu G, Hirohashi Y, Moreau L, Iyer D, Mukkavalli S, Parmar K, Zambrano G, Jiang L, Yi D, Manske M, Gwin K, King RL, Cerhan JR, Wu X, Lou Z, Shapiro GI, Witzig T, D'Andrea A. J Clin Invest. 2025 Jul 3;135(17):e193006. doi: 10.1172/JCI193006. eCollection 2025 Sep 2. PubMed |
| Mutations in MLL3 promote breast cancer progression via HIF1alpha-dependent intratumoral recruitment and differentiation of regulatory T cells. Boutet M, Nishitani K, Couturier N, Erler P, Zhang Z, Militello AM, Coutinho De Miranda M, Barbieux E, Guillen E, Leavenworth JW, Suzuki M, Sparano JA, Lu J, Fineberg SA, Wang Y, Mani SA, Montagna C, Guo W, Lauvau G. Immunity. 2025 Aug 12;58(8):2035-2053.e9. doi: 10.1016/j.immuni.2025.07.008. Epub 2025 Jul 31. PubMed |
| PACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer. Young AA, Juhler IG, Pierce JR, Bohlin HE, Harper HA, Onishile DS, Chua RN, Liu ME, Gardner EN, Elzey BD, Cottrell KA. RNA. 2025 Oct 16;31(11):1599-1618. doi: 10.1261/rna.080637.125. PubMed |
| Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis. Khan A, Yen FS, Unlu G, DelGaudio NL, Erdal R, Xiao M, Wangdu K, Cho K, Gamazon ER, Patti GJ, Birsoy K. Cell Metab. 2025 Nov 4;37(11):2220-2232.e8. doi: 10.1016/j.cmet.2025.09.015. Epub 2025 Oct 10. PubMed |
| SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation. Luo M, Mo J, Wang Z, Wei H, Chen K, Shen L, Wang Y, Li L, Chen Y, Chen W, Li X, Feng H, Wang X, Zhou H, Li B, Xu F, Zhao Q, Xu Y, Che J, Zou P, Zhang R, Dong X, Xie W. Nat Commun. 2025 Nov 3;16(1):9671. doi: 10.1038/s41467-025-64674-7. PubMed |
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