pCRIS-PITChv2-Puro-dTAG (BRD4) Citations (16)
Originally described in: The dTAG system for immediate and target-specific protein degradation.Nabet B, Roberts JM, Buckley DL, Paulk J, Dastjerdi S, Yang A, Leggett AL, Erb MA, Lawlor MA, Souza A, Scott TG, Vittori S, Perry JA, Qi J, Winter GE, Wong KK, Gray NS, Bradner JE Nat Chem Biol. 2018 May;14(5):431-441. doi: 10.1038/s41589-018-0021-8. Epub 2018 Mar 26. PubMed Journal
Articles Citing pCRIS-PITChv2-Puro-dTAG (BRD4)
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| Locus-Specific Knock-In of a Degradable Tag for Target Validation Studies. Brand M, Winter GE. Methods Mol Biol. 2019;1953:105-119. doi: 10.1007/978-1-4939-9145-7_7. PubMed |
| MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1. Popay TM, Wang J, Adams CM, Howard GC, Codreanu SG, Sherrod SD, McLean JA, Thomas LR, Lorey SL, Machida YJ, Weissmiller AM, Eischen CM, Liu Q, Tansey WP. Elife. 2021 Jan 8;10. pii: 60191. doi: 10.7554/eLife.60191. PubMed |
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J.
Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5.
PubMed
Associated Plasmids |
| Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery. Siegenfeld AP, Roseman SA, Roh H, Lue NZ, Wagen CC, Zhou E, Johnstone SE, Aryee MJ, Liau BB. Nat Commun. 2022 Jul 20;13(1):4199. doi: 10.1038/s41467-022-31857-5. PubMed |
| Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system. Abuhashem A, Hadjantonakis AK. STAR Protoc. 2022 Sep 16;3(3):101660. doi: 10.1016/j.xpro.2022.101660. Epub 2022 Sep 7. PubMed |
| Proteomic discovery of chemical probes that perturb protein complexes in human cells. Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. PubMed |
| KDM3A and KDM3B Maintain Naive Pluripotency Through the Regulation of Alternative Splicing. Dillingham CM, Cormaty H, Morgan EC, Tak AI, Esgdaille DE, Boutz PL, Sridharan R. bioRxiv [Preprint]. 2024 Jan 23:2023.05.31.543088. doi: 10.1101/2023.05.31.543088. PubMed |
| TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells. Scott TG, Sathyan KM, Gioeli D, Guertin MJ. PLoS Genet. 2024 Feb 20;20(2):e1011159. doi: 10.1371/journal.pgen.1011159. eCollection 2024 Feb. PubMed |
| Human promoter directionality is determined by transcriptional initiation and the opposing activities of INTS11 and CDK9. Eaton JD, Board J, Davidson L, Estell C, West S. Elife. 2024 Jul 8;13:RP92764. doi: 10.7554/eLife.92764. PubMed |
| Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies. He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu XS, Mannan R, Mahapatra S, Redin E, Cho H, Bao Y, Kandarpa M, Ching-Yi Tien J, Wang X, Eyunni S, Zheng Y, Kim N, Zheng H, Hou S, Su F, Miner SJ, Mehra R, Cao X, Abbineni C, Samajdar S, Ramachandra M, Dhanasekaran SM, Talpaz M, Parolia A, Rudin CM, Vakoc CR, Chinnaiyan AM. Cancer Cell. 2024 Aug 12;42(8):1336-1351.e9. doi: 10.1016/j.ccell.2024.06.006. Epub 2024 Jul 18. PubMed |
| Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint. Blears D, Lou J, Fong N, Mitter R, Sheridan RM, He D, Dirac-Svejstrup AB, Bentley D, Svejstrup JQ. Mol Cell. 2024 Dec 19;84(24):4790-4807.e11. doi: 10.1016/j.molcel.2024.10.012. Epub 2024 Nov 5. PubMed |
| KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells. Dillingham CM, Cormaty H, Morgan EC, Tak AI, Esgdaille DE, Boutz PL, Sridharan R. iScience. 2025 May 8;28(6):112612. doi: 10.1016/j.isci.2025.112612. eCollection 2025 Jun 20. PubMed |
| DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation. Lee C, Eldridge MJG, Gonzalez-Lozano MA, Bresnahan T, Niday Z, Del Camino D, Fu T, Paulo JA, Moran MM, Helaine S, Harper JW. Nat Struct Mol Biol. 2025 Oct;32(10):2060-2075. doi: 10.1038/s41594-025-01581-x. Epub 2025 Jun 17. PubMed |
| The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing. Fowler CE, O'Hearn NA, Salus GJ, Singh A, Boutz PL, Lees JA. iScience. 2025 Jun 20;28(7):112965. doi: 10.1016/j.isci.2025.112965. eCollection 2025 Jul 18. PubMed |
| ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains. Reinders M, Kravic B, Gahlot P, Koska S, van den Boom J, Schulze N, Levantovsky S, Kleine S, Kaiser M, Kulathu Y, Behrends C, Meyer H. EMBO J. 2025 Sep;44(18):5086-5111. doi: 10.1038/s44318-025-00517-x. Epub 2025 Jul 29. PubMed |
| DNA methylation insulates genic regions from CTCF loops near nuclear speckles. Roseman SA, Siegenfeld AP, Lee C, Lue NZ, Waterbury AL, Liau BB. Elife. 2025 Sep 3;13:RP102930. doi: 10.7554/eLife.102930. PubMed |
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