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Cancer associated talin point mutations disorganise cell adhesion and migration.
Azizi L, Cowell AR, Mykuliak VV, Goult BT, Turkki P, Hytonen VP
Sci Rep. 2021 Jan 11;11(1):347. doi: 10.1038/s41598-020-77911-4. PubMed Article

Plasmids from Article

ID Plasmid Purpose
166112pEGFP_WT-talin1 (1-2541)For expression of full-length wild-type mouse talin-1 in mammalian cells. Contains C-terminal EGFP tag.
166113pEGFP_P229L-talin1 (1-2541)expresses talin-1-P229L in mammalian cells
166114pEGFP_I392N-talin1 (1-2541)expresses talin-1-I392N in mammalian cells
166115pEGFP_V577D-talin1 (1-2541)expresses talin-1-V577D in mammalian cells
166116pEGFP_A893E-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation A893E in mammalian cells. Contains C-terminal EGFP tag.
166117pEGFP_R1368W-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation R1368W in mammalian cells. Contains C-terminal EGFP tag.
166118pEGFP_Y1389C-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation Y1389C in mammalian cells. Contains C-terminal EGFP tag.
166119pEGFP_L1539P-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation L1539P in mammalian cells. Contains C-terminal EGFP tag.
166120pEGFP_S1750F-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation S1750F in mammalian cells. Contains C-terminal EGFP tag.
166121pEGFP_E1770Q-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation E1770Q in mammalian cells. Contains C-terminal EGFP tag.
166122pEGFP_D2086V-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation D2086V in mammalian cells. Contains C-terminal EGFP tag.
166123pEGFP_L2509P-talin1 (1-2541)For expression of full-length mouse talin-1 carrying mutation L2509P in mammalian cells. Contains C-terminal EGFP tag.
166124pEGFP_∆DD-talin1 (1-2493)For expression of mouse talin-1 (residues 1-2493) containing C-terminal deletion of dimerization domain (∆DD) in mammalian cells. Contains C-terminal EGFP tag.
166125pEGFP_∆R13–DD-talin1 (1-2299)For expression of mouse talin-1 (residues 1-2299) with C-terminal deletion of dimerization domain and R13 (∆R13-DD) in mammalian cells. Contains C-terminal EGFP tag.

Antibodies from Article