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Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.
Holler CJ, Taylor G, Deng Q, Kukar T
eNeuro. 2017 Aug 18;4(4). pii: eN-NWR-0100-17. doi: 10.1523/ENEURO.0100-17.2017. eCollection 2017 Jul-Aug.
PubMed Article

Plasmids from Article

ID Plasmid Purpose
176915pcDNA3.1(+)_Paragranulin+linker 1express Paragranulin with linker 1 in mammalian cells
176917pcDNA3.1(+)_Paragranulin-no linkerexpress Paragranulin without linker 1 in mammalian cells
176918pcDNA3.1(+)_Granulin 1+linker2express Granulin 1 with linker 2 in mammalian cells
176919pcDNA3.1(+)_Granulin 1-no linkerexpress Granulin 1 without linker 2 in mammalian cells
176920pcDNA3.1(+)_Granulin 2+linker3express Granulin 2 with linker 3 in mammalian cells
176921pcDNA3.1(+)_Granulin 2-no linkerexpress Granulin 2 without linker 3 in mammalian cells
176922pcDNA3.1(+)_Granulin 3+linker4express Granulin 3 with linker 4 in mammalian cells
176923pcDNA3.1(+)_Granulin 3-no linkerexpress Granulin 3 without linker 4 in mammalian cells
176924pcDNA3.1(+)_Granulin 4+linker5express Granulin 4 with linker 5 in mammalian cells
176925pcDNA3.1(+)_Granulin 4-no linkerexpress Granulin 4 without linker 5 in mammalian cells
176926pcDNA3.1(+)_Granulin 5+linker6express Granulin 5 with linker 6 in mammalian cells
176927pcDNA3.1(+)_Granulin 5-no linkerexpress Granulin 5 without linker 6 in mammalian cells
176928pcDNA3.1(+)_Granulin 6+linker7express Granulin 6 with linker 7 in mammalian cells
176929pcDNA3.1(+)_Granulin 6-no linkerexpress Granulin 6 without linker 7 in mammalian cells
176930pcDNA3.1(+)_Granulin 7+linker8express Granulin 7 with linker 8 in mammalian cells
176931pcDNA3.1(+)_Granulin 7-no linkerexpress Granulin 7 without linker 8 in mammalian cells

Antibodies from Article