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A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns.

Wissing C, Eschholz LS, Maheu M, Sauter K, Morellini F, Wiegert JS, Dieter A
PLoS Biol. 2025 Jul 7;23(7):e3003228. doi: 10.1371/journal.pbio.3003228. eCollection 2025 Jul. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
192587PRS_8-ChrimsonR-tdTomatoAAV-vector for optogenetic activation of noradrenergic neurons
192589PRS_8-eGFPAAV-vector for fluorescent labeling of noradrenergic neurons
210399PRS_8-jRGECO1aAAV-vector for fluorescent calcium measurements in the red spectrum from noradrenergic neurons
210400PRS_8-GCaMP8mAAV-vector for fluorescent calcium measurements in the green spectrum from noradrenergic neurons

Antibodies from Article