A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.
Dahimene S, Page KM, Nieto-Rostro M, Pratt WS, D'Arco M, Dolphin AC
Neurobiol Dis. 2016 Sep;93:243-56. doi: 10.1016/j.nbd.2016.05.020. Epub 2016 May 31.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 206112 | Cav2.1 R57A, R59A pMT2 | expression of rat Cav2.1 calcium channel with R57A and R59A mutations that prevent G-protein modulation |
| 206122 | Cav2.1 EA2, R57A, R59A pMT2 | expression of rabbit Cav2.1 calcium channel with a CaV2.1-P1217fs mutation causing a truncated protein, (EA2). R57A R59A mutations prevent dominant-negative suppression of Cav2.1 currents |