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CAR-neutrophils produced in vivo to treat glioma.

Chang Y, Shao K, Li H, Jin G, Bentley RT, McCain RR, Crain CJ, Shen J, Tan Y, Liang PY, Harper HA, Torregrosa-Allen S, Elzey BD, Vanhaezebrouck IF, Cohen-Gadol AA, Dong C, Zhu Y, Wang Y, Luo J, Lian XL, Bao X
Nat Biomed Eng. 2026 Apr 24:10.1038/s41551-026-01656-0. doi: 10.1038/s41551-026-01656-0. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
213975modRNAc1 2x k-turn CreCre recombinase gene in modRNA cap1 vector
213976modRNAc1 2x k-turn dTomatodTomato gene in modRNA cap1 vector
213977modRNAc1 L7Ae miR142-miR223L7Ae gene and miR142/223 binding sites in modRNA cap1 vector
213978modRNAc1 L7Ae-eGFP miR142-miR223L7Ae-P2A-eGFP gene and miR142/223 binding sites in modRNA cap1 vector
213984modRNAc1 2x k-turn CLTX msCD28-CD3z CARChlorotoxin (CLTX)-CAR msCD3z gene in modRNA cap1 vector
213985modRNA1 2x k-turn CLTX CD3z CARChlorotoxin (CLTX)-CAR huCD3z gene (first generation without any co-stimulatory domain) in modRNA cap1 vector

Antibodies from Article