A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular L-lactate dynamics.
Kamijo Y, Machler P, Ness N, Vu CQ, Kusakizako T, Mannuthodikayil J, Ku Z, Boisvert M, Grebenik E, Miyazaki I, Hashizume R, Sato H, Liu R, Hori Y, Tomita T, Katayama T, Furube A, Caraveo G, Paquet ME, Drobizhev M, Nureki O, Arai S, Brancaccio M, Campbell RE, Kleinfeld D, Nasu Y
Nat Commun. 2025 Oct 29;16(1):9531. doi: 10.1038/s41467-025-64484-x.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 223255 | pBAD-R-eLACCO2 | Biosensor for extracellular L-lactate |
| 223256 | pBAD-R-eLACCO2.1 | Control biosensor for extracellular L-lactate |
| 223257 | pBAD-R-deLACCOctrl | Biosensor for intracellular L-lactate |
| 223258 | pcDNA-IgK-R-eLACCO2-COBRA | Biosensor for extracellular L-lactate |
| 223259 | pcDNA-IgK-R-eLACCO2.1-COBRA | Control biosensor for extracellular L-lactate |
| 223260 | pcDNA-IgK-R-deLACCOctrl-COBRA | Biosensor for intracellular L-lactate |
| 223344 | pAAV-gfaABC1D-IgK-R-deLACCO1-COBRA | Biosensor for extracellular L-lactate |
| 223345 | pAAV-gfaABC1D-IgK-R-eLACCO2-COBRA | Biosensor for extracellular L-lactate |
| 223346 | pAAV-gfaABC1D-IgK-R-eLACCO2.1-COBRA | Biosensor for extracellular L-lactate |
| 223347 | pAAV-hSyn-IgK-R-deLACCO1-COBRA | Biosensor for extracellular L-lactate |
| 223348 | pAAV-hSyn-IgK-R-eLACCO2-COBRA | Biosensor for extracellular L-lactate |
| 223349 | pAAV-hSyn-IgK-R-eLACCO2.1-COBRA | Biosensor for extracellular L-lactate |