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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.

Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM
Cell. 2024 Sep 6:S0092-8674(24)00908-5. doi: 10.1016/j.cell.2024.08.017. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
224261pProEx H-Ras(G12C) CLProtein purification of H-Ras (G12C)
224262pProEx N-Ras(G12C) CLProtein purification of N-Ras (G12C)
224263pProEx RalA(G23C) CLProtein purification of RalA (G23C)
224264pProEx Rap1A(G12C, L96F) CLProtein purification of Rap1A (G12C, L96F)
224265pProEx Ypt1(S17C) CLProtein purification of Ypt1 (S17C)
224266pProEx Rheb(R15C) CLProtein purification of Rheb (R15C)
224267pProEx Rit1(G47C) CLProtein purification of Rit1 (G47C)
224268pProEx M-Ras(G22C) CLProtein purification of M-Ras (G22C)
224269pProEx Rac1(G12C) CLProtein purification of Rac1 (G12C)
224270pProEx Rac1(G12C, K96H) CLProtein purification of Rac1 (G12C, K96H)
224271pProEx RhoA(G14C) CLProtein purification of RhoA (G14C)
224273pProEx Rab5C(S30C) CLProtein purification of Rab5C (S30C)
224274pcDNA3.1(+) EGFP-RalA(WT)Cell transfection and expression of RalA
224275pcDNA3.1(+) EGFP-RalA(G23C)cell transfection and expreswsion of RalA (G23C)
224276pcDNA3.1(+) EGFP-Rap1A(WT)Cell transfection and expression of Rap1A
224277pcDNA3.1(+) EGFP-Rap1A(G12C, L96F)Cell transfection and expression of Rap1A (G12C, L96F)
224278pcDNA3.1(+) EGFP-Rac1(WT)Cell transfection and expression of Rac1
224279pcDNA3.1(+) EGFP-Rac1(G12C)Cell transfection and expression of Rac1 (G12C)
224280pcDNA3.1(+) EGFP-Rac1(P29S)Cell transfection and expression of Rac1 (P29S)
224281pcDNA3.1(+) EGFP-Rac1(G12C, K96H)Cell transfection and expression of Rac1 (G12C, K96H)
224282pcDNA3.1(+) EGFP-Rac1(G12C, K96H, P29S)Cell transfection and expression of Rac1 (G12C, K96H, P29S)
224283pcDNA3.1(+) K-Ras(WT)Cell transfection and expression of K-Ras
224284pcDNA3.1(+) K-Ras(G12C) Cell transfection and expression of K-Ras (G12C)
224285pcDNA3.1(+) R-Ras1(WT)Cell transfection and expression of R-Ras1
224286pcDNA3.1(+) R-Ras1(G38C)Cell transfection and expression of R-Ras1 (G38C)
224287pcDNA3.1(+) M-Ras(WT) Cell transfection and expression of M-Ras
224288pcDNA3.1(+) M-Ras(G22C)Cell transfection and expression of M-Ras (G22C)
224289pcDNA3.1(+) Rheb(WT)Cell transfection and expression of Rheb
224290pcDNA3.1(+) Rheb(R15C)Cell transfection and expression of Rheb (R15C)

Antibodies from Article