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Monitoring norepinephrine release in vivo using next-generation GRAB(NE) sensors.

Feng J, Dong H, Lischinsky JE, Zhou J, Deng F, Zhuang C, Miao X, Wang H, Li G, Cai R, Xie H, Cui G, Lin D, Li Y
Neuron. 2024 Jun 19;112(12):1930-1942.e6. doi: 10.1016/j.neuron.2024.03.001. Epub 2024 Mar 27. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
208686pAAV-hsyn-NE2mExpresses the genetically-encoded fluorescent norepinephrine (NE) sensor GRAB_NE2m in neurons
208687pAAV-hsyn-NE2hExpresses the genetically-encoded fluorescent norepinephrine (NE) sensor GRAB_NE2h in neurons
208688pminiTol2-HuC-NE2mExpresses the genetically-encoded fluorescent norepinephrine (NE) sensor GRAB_NE2m pan-neuronally in zebrafish
208689pminiTol2-HuC-NE2hExpresses the genetically-encoded fluorescent norepinephrine (NE) sensor GRAB_NE2h pan-neuronally in zebrafish
208690pDisplay-NE2m-IRES-mCherry-CAAXExpresses the genetically-encoded fluorescent norepinephrine (NE) sensor GRAB_NE2m and a membrane-localized mcherry in mammalian cells
208691pDisplay-NE2h-IRES-mCherry-CAAXExpresses the genetically-encoded fluorescent norepinephrine (NE) sensor GRAB_NE2h and a membrane-localized mcherry in mammalian cells

Antibodies from Article