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Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network

Boutelle AM, Mabene AR, Yao D, Xu H, Wang M, Tang YJ, Lopez SS, Sinha S, Demeter J, Cheng R, Benard BA, McCrea EM, Valente LJ, Drainas AP, Fischer M, Majeti R, Petrov DA, Jackson PK, Yang F, Winslow MM, Bassik MC, Attardi LD
Cell Death Differ (2025) (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
227943pGH020 sgZmat3.1sgRNA targeting Zmat3, GFP, neomycin resistance, Mammalian expression, Mouse targeting, lentiviral, CRISPR
227944pGH020 sgZmat3.2sgRNA targeting Zmat3, GFP, neomycin resistance, Mammalian expression, Mouse targeting, lentiviral, CRISPR
227945pMCB320 sgCdkn1a.1sgRNA targeting Cdkn1a, mCherry, puromycin resistance, Mammalian expression, Mouse targeting, lentiviral, CRISPR
227946pMCB320 sgCdkn1a.2sgRNA targeting Cdkn1a, mCherry, puromycin resistance, Mammalian expression, Mouse targeting, lentiviral, CRISPR
227947pGH020 sgp53sgRNA targeting p53, GFP, neomycin resistance, Mammalian expression, Mouse targeting, lentiviral, CRISPR
228115pMCB320 sgControl (ACOCB)Safe targeting sgRNA
228144pMCB320 sgControl (GEA)Safe targeting sgRNA
228193pGH020 sgControl (GEA)Safe targeting sgRNA
228194pGH020 sgControl (ACOCB)Safe targeting sgRNA

Antibodies from Article