Dual functional genomics reveals a broad and convergent landscape of asciminib resistance in BCR::ABL1

Sokirniy I, Pritchard J
Genome Med. 2026

Plasmids from Article

ID	Plasmid	Purpose
210435	pUltra BCR-ABL V468F	Lentiviral expression of BCR-ABL V468F
235006	pUltra BCR-ABL D381G	Lentiviral expression of BCR-ABL D381G (kinase dead variant)
235007	pUltra BCR-ABL G76R	Lentiviral expression of BCR-ABL G76R
235008	pUltra BCR-ABL G130E	Lentiviral expression of BCR-ABL G130E
235009	pUltra BCR-ABL Y342A	Lentiviral expression of BCR-ABL Y342A
235010	pUltra BCR-ABL Y139C	Lentiviral expression of BCR-ABL Y139C
235011	pUltra BCR-ABL F72P	Lentiviral expression of BCR-ABL F72P
235012	pUltra BCR-ABL P112L	Lentiviral expression of BCR-ABL P112L
235013	pUltra BCR-ABL T277A	Lentiviral expression of BCR-ABL T277A
235014	pUltra BCR-ABL K294E	Lentiviral expression of BCR-ABL K294E
235015	pUltra BCR-ABL H375A	Lentiviral expression of BCR-ABL H375A
235016	pUltra BCR-ABL Y253H	Lentiviral expression of BCR-ABL Y253H
235017	pUltra BCR-ABL D325G	Lentiviral expression of BCR-ABL D325G
235018	pUltra BCR-ABL M244T	Lentiviral expression of BCR-ABL M244T
235019	pUltra BCR-ABL V73A	Lentiviral expression of BCR-ABL V73A
235020	pUltra BCR-ABL M351T	Lentiviral expression of BCR-ABL M351T
235021	pUltra BCR-ABL E292V	Lentiviral expression of BCR-ABL E292V
235022	pUltra BCR-ABL Y139H	Lentiviral expression of BCR-ABL Y139H
235024	pUltra BCR-ABL I502L	Lentiviral expression of BCR-ABL I502L
235025	pUltra BCR-ABL E505G	Lentiviral expression of BCR-ABL E505G
235026	pUltra BCR-ABL V73A Y253H	Lentiviral expression of BCR-ABL V73A Y253H
235027	pUltra BCR-ABL M244V	Lentiviral expression of BCR-ABL M244V
235028	pUltra BCR-ABL F317L	Lentiviral expression of BCR-ABL F317L
235029	pUltra BCR-ABL F311L	Lentiviral expression of BCR-ABL F311L
235030	pUltra BCR-ABL Y342A H375A	Lentiviral expression of BCR-ABL Y342A H375A
235031	pUltra BCR-ABL C464W	Lentiviral expression of BCR-ABL C464W FRET biosensor
235032	UbC Puro ABL FRET WT	Expression of BCR-ABL WT FRET biosensor
235033	UbC Puro ABL FRET F72P	Expression of BCR-ABL F72P FRET biosensor
235034	UbC Puro ABL FRET P112L	Expression of BCR-ABL P112L FRET biosensor
235035	UbC Puro ABL FRET V468F	Expression of BCR-ABL V468F FRET biosensor
235036	UbC Puro ABL FRET V73A	Expression of BCR-ABL V73A FRET biosensor
235037	UbC Puro ABL FRET Y253H	Expression of BCR-ABL Y253H FRET biosensor
235038	UbC Puro ABL FRET V73A Y253H	Expression of BCR-ABL V73A Y253H FRET biosensor
235039	UbC Puro ABL FRET M244V	Expression of BCR-ABL M244V FRET biosensor
235040	UbC Puro ABL FRET Y342A	Expression of BCR-ABL Y342A FRET biosensor
235041	UbC Puro ABL FRET V468F	Expression of BCR-ABL V468F FRET biosensor
235042	UbC Puro ABL mScarlet3	Expression of BCR-ABL mScarlet3 FRET control
235043	UbC Puro ABL mStayGold	Expression of BCR-ABL mStayGold FRET control
235047	Lenti ccdB Dang sgRNA Hyg sfGFP	Lentiviral sgRNA expression with optimized sgRNA scaffold vector with hygromycin and superfolder GFP. Also contains ccdB cassette for library cloning.
235048	Lenti ccdB sgRNA Hyg sfGFP	Lentiviral sgRNA expression vector with hygromycin and superfolder GFP. Also contains ccdB cassette for library cloning.
235049	UbC SHP2 FRET	Expression of SHP2 FRET biosensor to measure conformational state of SHP2
235050	UbC SHP2 E76G FRET	Expression of SHP2 E76G FRET biosensor to measure conformational state of SHP2 with activating mutation E76G